Reta phase 3 results out

[RockyP]

https://www.fiercebiotech.com/biotech/eli-lillys-obesity-triple-threat-smashes-efficacy-expectations-phase-3-proves-intolerable

I’m waiting for commentary from @Ghoul @Photon and others. They ratcheted these poor bastards up to 12 mg daily. Can’t imagine taking that much. Efficacy was above expectations but so was discontinuation rate (again, 12 mg is nuts).

Lilly has 7 more Reta trials in the works.

 

[chrzrd23]

Cagri also sucks metabolically. Who decided that a calcitonin agonist was a good idea? Let’s suppress both insulin and growth hormone at the same time!

Vig steve and his nonsense

 

[setters]

Cagrilintide SUCKS. That's why. You want to buy the rest of mine? I got no appetite suppression with 8mg reta until I was up to 1mg cagrilintide per week. But the cagrilintide made me feel like complete shit. It would suppress appetite for the first 3-4 days but I would feel like garbage with my head hurting constantly. Didn't want to do anything. Overall just down and yuck feeling. Not as bad as DNP lethargy but not far off. No thanks. I'll just add this is only my experience. Some people actually like cagrilintide.

Literally the worst, it's like getting hit by a bus

 

[Jason_orange12]

Literally the worst, it's like getting hit by a bus

Had some ready to start but this thread is putting me off might use tirz instead as a stacker

 

[setters]

Had some ready to start but this thread is putting me off might use tirz instead as a stacker

With what? Reta?

 

[SnowyMiami]

Literally the worst, it's like getting hit by a bus

Chase Irons reported stroke like symptoms after eating a peanut butter milk shake on Cagri and Reta.

 

[Trenunaki]

Cagri also sucks metabolically. Who decided that a calcitonin agonist was a good idea? Let’s suppress both insulin and growth hormone at the same time!

Friend, how would cagri supress GH? And supress insulin? if you mean lower levels of insulin being secreted, Id damn well hope the drug does that as its supposed to be a diabetic medicine and improve said disease independent of its appetite supression driven weight loss.

We have the clinical trials of the drug, fhe sides are the same GI discomfort common among all drugs in this class( though yes cagri isnt a Glp1).

Sure if cagri didnt work for you, dont use it. But youre just spouting nonsense.

 

[setters]

Chase Irons reported stroke like symptoms after eating a peanut butter milk shake on Cagri and Reta

Well I don't believe a word that comes out of that guy's mouth but yeah I would not recommend having a peanut butter milk shake on that combo.

 

[SubparMarioBro]

Friend, how would cagri supress GH? And supress insulin? if you mean lower levels of insulin being secreted, Id damn well hope the drug does that as its supposed to be a diabetic medicine and improve said disease independent of its appetite supression driven weight loss.

We have the clinical trials of the drug, fhe sides are the same GI discomfort common among all drugs in this class( though yes cagri isnt a Glp1).

Sure if cagri didnt work for you, dont use it. But youre just spouting nonsense.

Because Novo Nordisk made a shitty drug with off-target effects on calcitonin, which causes well-documented suppression of both insulin and growth hormone. This has been known for decades now. Here’s a paper from the 80s: Calcitonin, a diabetogenic hormone? - PubMed

“Plasma insulin and C-peptide responses to glucose were significantly reduced (P less than 0.01) by calcitonin at all times after the start of the test in both normal and IGT groups. The inhibitory action of oral glucose on glucagon secretion was partially prevented by calcitonin (P less than 0.01). Moreover, calcitonin completely blunted the GH rebound occurring at the end of the test. These findings demonstrate that calcitonin impairs glucose tolerance in man by both inhibiting glucose-induced insulin secretion (primary effect) and reducing glucose-mediated glucagon suppression (accessory effect).”

And a 1980s paper showing suppression of growth hormone secretion: Calcitonin inhibition of growth hormone-releasing hormone-induced GH secretion in normal men - PubMed

“These results indicate that: 1) CT blunts the GH response to GHRH; 2) CT infusion results in the stimulation of the hypothalamic-pituitary-adrenal axis, and 3) this effect is probably exerted at the hypothalamic level, since no direct activity of CT was documented in vitro on either GH or ACTH secretion.”

Cagri gets away with a lot because its shittiness is masked by the metabolic benefits of weight loss, but you’d be better off losing the weight without cagri.