Reta Microdosing (<1.5mg) to improve lipids?

[Banana Joe]

I had already asked here, but it sadly didn't get any replies.

How many of you guys are taking microdoses of Reta (<1.5mg?) mainly to improve HDL/LDL?
I have seen quite a few people on YT making similar claims, but Big Paul is the first one that provided actual numbers.

Other benefits should be:
- improved insulin sensitivity (might be even a given)
- reduced visceral and liver fat via glucagon receptor signaling


I always had bad HDL/LDL (hereditary) and have started taking 0.2mg e2d of Reta just recently. So far I feel no reduction in appetite, which is critical for me, as I have become a terrible eater over the years. If I feel no ill effects, I might up the dose to 0.3mg e2d.
Haven't gotten a new blood panel as my diet is a bit terrible atm, and I need to fix that first to get any meaningful data.

 

[Ateam2023]

Todays fbg was 85!!! Its never been that low lol , Ive done .75 mg of Reta in the last 10 days, and things seem to moving in the direction i hoped , appetite isn't effected, so far so good.

 

[Banana Joe]

Todays fbg was 85!!! Its never been that low lol , Ive done .75 mg of Reta in the last 10 days, and things seem to moving in the direction i hoped , appetite isn't effected, so far so good.

Though my FBG was always in the mid 80's, now you are making me want to try it again - just one more time. Goddamit!

I need to keep my LDL up for now, to somehow fake myself into qualifying for Evolocumab where I live.

 

[Ghoul]

Can any of you on around 1mg still overeat, or will even low that dose punish you with the known effects?
Given how much of a terrible eater I became, I am glad when, I once in a blue moon, have the desire to overeat a bit.

There's just no way to tell. Some people get NO appetite suppression at 4mg.

What I can tell you is if you stick pharma once weekly protocol, at an appetite suppressing dose, by the last day before your next dose, you have some room to "cheat" if you want to.

 

[ChemBB]

any of you on around 1mg still overeat

8mg Reta + 2mg Sema, still so hungry at night =/

 

[Banana Joe]

8mg Reta + 2mg Sema, still so hungry at night =/

At that dose, I'd eat no food at all - and drink a glass of water a day...

Ive done .75 mg of Reta in the last 10 days

Where was your FBG before you had started Reta? How big is a single dose for you, or you inject it daily?


@AIRBORNE DADDY How are things going on your end? Were you able to shed a bit more fat in the meantime?

 

[Ateam2023]

At that dose, I'd eat no food at all - and drink a glass of water a day...


Where was your FBG before you had started Reta? How big is a single dose for you, or you inject it daily?


@AIRBORNE DADDY How are things going on your end? Were you able to shed a bit more fat in the meantime?

my fbg was in the 90-95+ range, always right around 95 for my "monthly average" , i started .5 mg reta my first dose week 1, now week two i am dosing it .25 mg on Monday and Thursday. Today was my last weekly dose , i don't take my fbg everyday, (already went down that rabbit hole) so i will be checking it 2-3 times per week until i get to saturated state.

 

[Nidus]

I just checked how to get a prescription for Evolocumab where I live. I don't think I will be able to qualify. I know someone in the medical field, that mentioned a cardiologist who is apparently pretty generous with expensive examinations, I hope I can get at least heart MRT that way, without having to pay for it myself, as one has to, if there is no concrete indication for it.

Maybe that cardiologist can also be convinced to give Evolocumab, if I fake that I can't take any statins?
Will need a solid strategy for this, I guess....

Before you get Repatha you usually need to have 2 Doctors confirm that your lipids are greatly fucked and then see a Cardiogolist

I am currently trying for it and before the doctor makes a request i have to visit a lipidologist and do genetic testing plus a calcium scan of major arteries. I also need to document my BP on a daily basis plus track my symptoms while using a statin (rosu 5mg). It is a huge hassle but insurance requires detailed documentation and proof that i at least have tried it and it did not help or do much, its a big mess

 

[Banana Joe]

Before you get Repatha you usually need to have 2 Doctors confirm that your lipids are greatly fucked and then see a Cardiogolist

I am currently trying for it and before the doctor makes a request i have to visit a lipidologist and do genetic testing plus a calcium scan of major arteries. I also need to document my BP on a daily basis plus track my symptoms while using a statin (rosu 5mg). It is a huge hassle but insurance requires detailed documentation and proof that i at least have tried it and it did not help or do much, its a big mess

Jeez, at the beginning, before I had already looked into it myself, I thought:
Well, will get me 2 prescriptions for statins, complain about muscle pain after a few weeks, will do some googling how that pain is best described, and then get my shots. Done deal!

Are you in the EU?

 

[Nidus]

Jeez, at the beginning, before I had already looked into it myself, I thought:
Well, will get me 2 prescriptions for statins, complain about muscle pain after a few weeks, will do some googling how that pain is best described, and then get my shots. Done deal!

Are you in the EU?

Yes, EU.

I need to run the statin for at least 6 months and report all issues in detail, kind of writing up a diary. I've been running Rosu for a year already so that part is easy. I personally just wanna use repatha as it has so many other benefits + my lipids were always shit. Even 500mg Test and 280mg primo did not bulge my HDL down (it's always at 22) while LDL before i even went on TRT were at 269 -> Even doing major changes like adding fiber, ezemtibe, bempoic acid and so on my LDL barely moved down so i just wanna get repatha to have peace of mind

 

[ChemBB]

Welp, first time in +6 months I binged, last night.
8mg Reta + 2mg Sema.

Went out at 6PM and bought 5 x 300kcal pints of diet icecream, then spent the next 3 hours shitting liquid.

Bets on how much Sema I have to take for the hunger to go away?

 

[Banana Joe]

Yes, EU.

I need to run the statin for at least 6 months and report all issues in detail, kind of writing up a diary. I've been running Rosu for a year already so that part is easy. I personally just wanna use repatha as it has so many other benefits + my lipids were always shit. Even 500mg Test and 280mg primo did not bulge my HDL down (it's always at 22) while LDL before i even went on TRT were at 269 -> Even doing major changes like adding fiber, ezemtibe, bempoic acid and so on my LDL barely moved down so i just wanna get repatha to have peace of mind

Meh, that sounds I will have a really bad time getting a prescription.
Thanks for reporting though. I know one shady doc who pretty much prescribes anything, maybe I can fast track the process with him somehow?

 

[Banana Joe]

Welp, first time in +6 months I binged, last night.
8mg Reta + 2mg Sema.

Went out at 6PM and bought 5 x 300kcal pints of diet icecream, then spent the next 3 hours shitting liquid.

Bets on how much Sema I have to take for the hunger to go away?

Are we talking about 5 pints of Ben+Jerry size (500ml)? How on earth can you eat those 5 in one sitting?
Anyway, please try to not do stuff like that, given the current circumstances.

 

[ChemBB]

Are we talking about 5 pints of Ben+Jerry size (500ml)? How on earth can you eat those 5 in one sitting?

5 pints of Halo Top + Nick's diet icecream, ~470ml/260g
So ~1.3kg of icecream

How on earth can you eat those 5 in one sitting?

I've always had a monstrous appetite naturally. Which is kind of funny to me, given that I'm 5'6, lol.

I once entered a challenge to eat a $50 burrito at a restaurant. If you could eat the entire thing, the meal was free. Only one person had ever beaten it and they were a professional competitive eater.

I got damn close, but it had a bunch of stuff I don't like in it, and they wouldn't replace it with gram-equivalent substitutes. So eventually I couldn't stomach another bite of it. A real shame, but fun challenge.

Anyway, please try to not do stuff like that, given the current circumstances.

Aye, I know mate =/

What happens is that I get so hungry all I can think about is food and it's genuinely distracting. Trying to watch TV or play games I can only half-pay attention because I keep thinking about food, and it won't stop until I eat something.

Gonna go up to 3mg Sema this week, hopefully that helps.
I'm not sure I like Reta very much/that it's effective for me.

I had great results on 10mg Tirz + 2.5mg Sema

 

[ChemBB]

The strange bit is that despite binging for the first time, I woke up down 3lbs when my weightloss had slowed drastically recently.

Though I did sweat an absurd amount, which is unusual for me. Absolutely soaked my blanket + sheets (gross).

My total yesterday was only ~3,300-3,400kcal despite the binge.
Maybe my body needed a carb refeed?

 

[AIRBORNE DADDY]

At that dose, I'd eat no food at all - and drink a glass of water a day...


Where was your FBG before you had started Reta? How big is a single dose for you, or you inject it daily?


@AIRBORNE DADDY How are things going on your end? Were you able to shed a bit more fat in the meantime?

I look good for 54 after a test/tren cycle and 2mg arimidex a week.... but I've been running 9mg of tirz entire time and still put on 18lbs. I am a boozer as well so even a calorie deficit I add another 800 calories in alcohol lol. Anyway I just went to a trt test dose and gonna get back on reta. I'm always gonna be 5'9" and 224 but last year I was 250 without glp1s or test.

 

[Banana Joe]

I look good for 54 after a test/tren cycle and 2mg arimidex a week.... but I've been running 9mg of tirz entire time and still put on 18lbs. I am a boozer as well so even a calorie deficit I add another 800 calories in alcohol lol. Anyway I just went to a trt test dose and gonna get back on reta.

Keep at it, man!
Have you looked into no-calorie herbal alternatives to booze? I hear they are now pretty big in the US.
I think those 800kcal would be better spend on fruits, veggies, maybe a steak instead of chicken breast, and a bit more rice!

 

[Ateam2023]

a little update ! TL;DR,, , im on week 3 of .5 mg reta split on M/Thur, Todays fbg was 87! And Mondays weigh in i have lost .8 lbs, So everything has been moving in the direction i was hoping ( better fbg, improved health markers) I can only think that when i get my next blood panel my other numbers will have improved. Eating hasnt been effected per say, seems like i am less hungary in general , then some days i can eat more, Idk on that aspect of effectiveness though, Im not a real big eater anyway, i realllly don't like to eat much, makes "dieting" easy peezy, but a real chore when i want to bulk, im glad in a way that my current situation with injuries etc, allows me to comfortably eat at maintenance and the small reduction in lbs isn't affecting my body, or mind for that matter, i am getting more vascular as if i could get more veiny lol , All in all my approach to micro dosing Reta is at least doing what i was hoping for, Ymmv

 

[Banana Joe]

a little update ! TL;DR,, , im on week 3 of .5 mg reta split on M/Thur, Todays fbg was 87! And Mondays weigh in i have lost .8 lbs, So everything has been moving in the direction i was hoping ( better fbg, improved health markers) I can only think that when i get my next blood panel my other numbers will have improved. Eating hasnt been effected per say, seems like i am less hungary in general , then some days i can eat more, Idk on that aspect of effectiveness though, Im not a real big eater anyway, i realllly don't like to eat much, makes "dieting" easy peezy, but a real chore when i want to bulk,

Thanks for the report!
How is digestion affected by that microdose of Reta, do you feel there is already a noticeably slower gastric emptying going on?
Any side other effects like bloating or diarrhoea?
Do you have a somewhat steady diet, so any change in your upcoming bloodwork could likely be atributed to the Reta?

im glad in a way that my current situation with injuries etc, allows me to comfortably eat at maintenance

That sounds a lot like me. But I must say I would rather have to force food, if I were able to build muscle. But it is what it is I guess.

 

[Ateam2023]

Thanks for the report!
How is digestion affected by that microdose of Reta, do you feel there is already a noticeably slower gastric emptying going on?
Any side other effects like bloating or diarrhoea?
Do you have a somewhat steady diet, so any change in your upcoming bloodwork could likely be atributed to the Reta?


That sounds a lot like me. But I must say I would rather have to force food, if I were able to build muscle. But it is what it is I guess.

no bloating, and it seems my turds are a little more solid, i still shit like clockwork in the morning, My diet is "to steady" lol , i eat the same things everday, so my upcoming bloodwork will be a sure fire way of knowing how Reta has effected me.

 

[crees]

I don't think Reta does much at 1.5mg. As usual, influencers are blowing it out of proportion. Paul is just cruising and eating like a normal person right now, so comparing his lipids to when he was full on blasting isn’t really fair.

I’ve been taking 10mg of Cardarine daily and my lipids are the best they’ve ever been.

would you say is ok to jump straight at 10mg or is this the classic case of "we are all unique" ? thanks