How to counter EVERY AAS Side-effect

[docpepper]

I mean technically people here generally encourage others to take less stuff if they can safely meet their goals with less. The aim is harm reduction even if we still enjoy our steroids.

Right, the OP just ended his post with "what's your fucking excuse??" as if this place isn't full of guys talking about how to blast more/less/better gear.

 

[Kralteramon]

i am cocky.

it was found that these mice experienced a reduction of 36% and 41% in total cholesterol and LDL cholesterol upon activation of the Rev-erb.

showed significant reduction in total cholesterol (36%), LDL-C (41%) and triglycerides (40%) in response to SR9009 treatment. HDL-C levels were not affected by SR9009

SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to pro-inflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages
SR9009 prevents cardiomyocyte hypertrophy, reduces fibrosis, and halts heart failure progression in mice

In mice with pressure-induced cardiac hypertrophy caused by transverse aortic constriction, SR9009 lowered protein kinase B (AKT) expression and reduced cardiac hypertrophy
REV-ERBα activation by SR9009 inhibits transcription of inflammatory factors IL-1β, IL-6, MMP-9, and Ccl2 in astrocytes. SR9009 significantly attenuates hepatic damage and inflammatory responses, it is effective in suppressing clinical markers of liver damage, circulating lipids, hepatic fibrosis, and markers of inflammation
REV-ERBα overexpression partially or totally blunted dexamethasone-mediated induction of the catabolic (Atrogin, Murf1, Foxo1 and Foxo3a) and anti-anabolic (Klf15, Redd1 and Bcat2) genes
REV-ERBs are potently anticarcinogenic.
decreased REV-ERBα expression was associated with poor prognosis

The treatment with the small-molecule agonists of REV-ERBs SR9011 and SR9009 led to a reduction in the GSC proliferation rate

Are you a mouse? Squeek squeek. If the lipids effect is so pronounced. Just give us some bloodwork to prove it. You're mister smartass you must do some sort of periodical bloodwork no?

 

[David Gandy]

I appreciate your honesty and thanks for your thoughts on the third item.

i appreciate you appreciation

 

[iris]

Right, the OP just ended his post with "what's your fucking excuse??"

What's your excuse in terms of not trying to looking to mitigate side effects and explore the possibilities offered by certain compounds.

Assuming I read it correctly, OP

 

[David Gandy]

Why would you want to impersonate somebody? Don't you have some sort of identity?

why would you care

 

[Kralteramon]

why would you care

Because it's weird to use someone's name and profile picture without any hint that you're not the real person. What are you hiding?

 

[David Gandy]

Because it's weird to use someone's name and profile picture without any hint that you're not the real person. What are you hiding?

why would i be the real person?
im clearly not david gandy

 

[Kralteramon]

why would i be the real person?
im clearly not david gandy

because you're using his exact name and picture? Why clearly? I didn't even know who the f David Gandy was before you showed up. Clearly you know him well enough.

 

[iris]

I didn't even know who the f David Gandy was before you showed up. Clearly you know him well enough.

What

Dolce e Gabbana ads, lol

Maybe in the US you don't get those, as much as we do in Europe.

That Blue perfume is well nice, actually, lol

I have seen him out and about where I live, once.

 

[Kralteramon]

Noice. Neh I'm not really that attentive to perfume ads tbh. Let stand that I know any of the names. I know Johnney Depp from Sauvage though! I love that perfume damn.

 

[glpfun]

 

[glpfun]

Noice. Neh I'm not really that attentive to perfume ads tbh. Let stand that I know any of the names. I know Johnney Depp from Sauvage though! I love that perfume damn.

All you need to know is creed, everyone loves their colognes, they got a pineapply one, just expensive

 

[AlexDavis43]

More like useless thread. We already know how to deal with sides here. Just use the search function.. perhaps r/PEDs would be more appreciative of your hard work

"Perhaps r/subreddit would be more appreciative of your hard work" is like top 3 sickest burns

 

[xrayphoton13]

i dont see a problem with spoonfeeding
id love to have a high iq bloke tell me eveything i need to know without having to do my own research
but here are some studies for sr9009 if u want

The Role of REV-ERB Receptors in Cancer Pathogenesis

REV-ERB receptors are members of the nuclear receptor superfamily of proteins, which act as both intracellular receptors and transcription factors, therefore modulating the expression of target genes. REV-ERBs act as transcription repressors because of their unique structure. Their predominant...

www.mdpi.com

Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass - Scientific Reports

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and thermogenesis. We have previously demonstrated that Rev-erb-α is also an important regulator of skeletal muscle mitochondrial biogenesis and function, and autophagy. As such, Rev-erb-α over-expression...

www.nature.com

https://academic.oup.com/endo/article-abstract/141/10/3799/2987804?redirectedFrom=fulltext&login=false

Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial biogenesis in skeletal muscle

The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to be core members of the circadian clock and participate in the regulation of a diverse set of metabolic functions. Due to their overlapping tissue expression patterns and gene expression profiles, REV-ERBβ is thought to be...

journals.plos.org

Frontiers | Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway

Backgrounds: The circadian clock protein Rev-erbα is a crucial regulator of circadian rhythms that affects multiple molecular, cellular, and physiology pathw...

doi.org

REV-ERB agonism improves liver pathology in a mouse model of NASH

Non-alcoholic fatty liver disease (NAFLD) affects a significant number of people worldwide and currently there are no pharmacological treatments. NAFLD often presents with obesity, insulin resistance, and in some cases cardiovascular diseases. There is a clear need for treatment options to...

journals.plos.org

Your studies are either on mice or theoretical so we can't put much weight on them. Mice aren't humans. If it helped cure cancer it would be used for that. If you want to cure fatty liver take a glp-1. We have many more years of safety data.

 

[UncleBuns]

All you did is give a list of common side effects and the common drugs used for those side effects. Anybody can Google that information rather quickly, this list is not unique or interesting. You also don't talk about anything beyond what drugs can be used for those side effects. A lot of side effects have non-drug ways to help or alleviate them.

Welcome to the forum but acting like you're something special for sharing all list of very common knowledge is a weird way to start.

 

[dinfar1337]

I mean technically people here generally encourage others to take less stuff if they can safely meet their goals with less. The aim is harm reduction even if we still enjoy our steroids.

inject more test, become bigger than the rest

 

[Sicsemptyran]

you cant run cancerine in the long run

it’s funny you mention cardarine as causing cancer since it was animal studies that showed great promise in lipid reductions/fat distribution/glucose control that prompted pharma companies to study it more. Unfortunately it failed miserably when longer term studies showed it to cause cancer. Common outcome of exercise memetics.

I’m assuming you are positive that SR9009 doesn’t cause cancer because pharma companies have run similar studies?

(it’s sarcastic, I know they haven’t. I wouldn’t touch that shit with a 9 foot pole)

 

[dinfar1337]

it’s funny you mention cardarine as causing cancer since it was animal studies that showed great promise in lipid reductions/fat distribution/glucose control that prompted pharma companies to study it more. Unfortunately it failed miserably when longer term studies showed it to cause cancer. Common outcome of exercise memetics.

I’m assuming you are positive that SR9009 doesn’t cause cancer because pharma companies have run similar studies?

(it’s sarcastic, I know they haven’t. I wouldn’t touch that shit with a 9 foot pole)

now look at the limited human studies on cardarine and cancer, 0 correlation on proper doses

 

[Sicsemptyran]

now look at the limited human studies on cardarine and cancer, 0 correlation on proper doses

Alright no offense but there’s quite literally never been a study long enough and thorough enough to show even remotely whether cardarine causes cancer or not in humans.

Given the overwhelming evidence in animal studies, I also can’t recommend against cardarine enough. Especially when there’s drugs with similar effects that are proven to not cause cancer.

 

[dinfar1337]

Alright no offense but there’s quite literally never been a study long enough and thorough enough to show even remotely whether cardarine causes cancer or not in humans.

Given the overwhelming evidence in animal studies, I also can’t recommend against cardarine enough. Especially when there’s drugs with similar effects that are proven to not cause cancer.

its 100% a possibility im not denying it. but ofc if you run the dosages they would be giving in most studies >= 100mg cardarine to those rats. and the lowest ive been able to find is like 1mg per kg of bodyweight. if you take for that for your whole life it makes sense you get cancer. im just spewing debate out cuz im bored asf from the original subject tho haha