glpfun
Member
Oh look another idiot twink, we already got enough of those, no thanks
MESO-Rx
Anabolic Steroids
How to counter EVERY AAS Side-effect
- Thread starter David Gandy
- Start date
David Gandy
New Member
twink? where? i love twinks
iris
New Member
That's what I read, too.
I had not heard of this being bioavailable this way, tbh, just through injection.
Incidentally, I was looking for it.
A lot of its benefits are similar to cardarine, e.g. it is supposed to be cardio protective and it was banned by sporting authorities.
I do not see an issue with you wanting to try this, when so many others take/have tried cardarine.
But I am just wondering where/if you actually saw a real impact.
You probably took it in conjunction with other things, so perhaps any possible effect would be difficult to ascertain.
No?
Kralteramon
Member
i dont see a problem with spoonfeeding
id love to have a high iq bloke tell me eveything i need to know without having to do my own research
but here are some studies for sr9009 if u want
The Role of REV-ERB Receptors in Cancer Pathogenesis
REV-ERB receptors are members of the nuclear receptor superfamily of proteins, which act as both intracellular receptors and transcription factors, therefore modulating the expression of target genes. REV-ERBs act as transcription repressors because of their unique structure. Their predominant...www.mdpi.com
Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass - Scientific Reports
The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and thermogenesis. We have previously demonstrated that Rev-erb-α is also an important regulator of skeletal muscle mitochondrial biogenesis and function, and autophagy. As such, Rev-erb-α over-expression...www.nature.com
Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial biogenesis in skeletal muscle
The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to be core members of the circadian clock and participate in the regulation of a diverse set of metabolic functions. Due to their overlapping tissue expression patterns and gene expression profiles, REV-ERBβ is thought to be...journals.plos.org
Frontiers | Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway
Backgrounds: The circadian clock protein Rev-erbα is a crucial regulator of circadian rhythms that affects multiple molecular, cellular, and physiology pathw...doi.org
REV-ERB agonism improves liver pathology in a mouse model of NASH
Non-alcoholic fatty liver disease (NAFLD) affects a significant number of people worldwide and currently there are no pharmacological treatments. NAFLD often presents with obesity, insulin resistance, and in some cases cardiovascular diseases. There is a clear need for treatment options to...
Did you just indiredtly label yourself as a high IQ bloke? You know, that actually makes you come off as stupid and cocky. Why are you dodging my bloodwork question? If you really believe that this stuff works. Prove it. What parameters are we looking for? What is the net outcome in terms of performance enhancement? We're only interested in tangible results. What are we getting? And how do we measure it?
BamaCrazy
Banned
IQ is overrated. The last high IQ member we had injected 90iu of GH at one time. lol
David Gandy
New Member
you cant run cancerine in the long run
iris
New Member
Yes.
I was just saying that if people are prepared to give cardarine a go because of its alleged properties (leave the cancer stuff out of the equation. Many here have taken it), I do understand why you wanted to try this.
That's all.
Kralteramon
Member
By the way David Gandy. Are you a catfish?
iris
New Member
OP David,
Are you going to write us a little intro in the new members thingy?
Thank you
Are you going to write us a little intro in the new members thingy?
Thank you
David Gandy
New Member
i am cocky.
it was found that these mice experienced a reduction of 36% and 41% in total cholesterol and LDL cholesterol upon activation of the Rev-erb.
showed significant reduction in total cholesterol (36%), LDL-C (41%) and triglycerides (40%) in response to SR9009 treatment. HDL-C levels were not affected by SR9009
SR9009 treatment of bone marrow-derived mouse macrophages (BMDM) reduced the polarization of BMDMs to pro-inflammatory M1 macrophage while increasing the polarization of BMDMs to anti-inflammatory M2 macrophages
SR9009 prevents cardiomyocyte hypertrophy, reduces fibrosis, and halts heart failure progression in mice
In mice with pressure-induced cardiac hypertrophy caused by transverse aortic constriction, SR9009 lowered protein kinase B (AKT) expression and reduced cardiac hypertrophy
REV-ERBα activation by SR9009 inhibits transcription of inflammatory factors IL-1β, IL-6, MMP-9, and Ccl2 in astrocytes. SR9009 significantly attenuates hepatic damage and inflammatory responses, it is effective in suppressing clinical markers of liver damage, circulating lipids, hepatic fibrosis, and markers of inflammation
REV-ERBα overexpression partially or totally blunted dexamethasone-mediated induction of the catabolic (Atrogin, Murf1, Foxo1 and Foxo3a) and anti-anabolic (Klf15, Redd1 and Bcat2) genes
REV-ERBs are potently anticarcinogenic.
decreased REV-ERBα expression was associated with poor prognosis
The treatment with the small-molecule agonists of REV-ERBs SR9011 and SR9009 led to a reduction in the GSC proliferation rate
David Gandy
New Member
i am not david gandy himself ofc
just a fan
David Gandy
New Member
glpfun
Member
Trash sleep is the biggest side for me, and it's a big one.
I manage it through a combination of ancillaries, but not particularly well.
I manage it through a combination of ancillaries, but not particularly well.
If you can't tell who it is, it's probably you.
docpepper
Member
You're on "thinksteroids," nobody's making excuses here to not do PEDS lol
glpfun
Member
I mean technically people here generally encourage others to take less stuff if they can safely meet their goals with less. The aim is harm reduction even if we still enjoy our steroids.
David Gandy
New Member
idk about the other two
dihexa + p21 + na semax amidate is gonna boost tf out of your cognition
it will increase your overall intelligence, emotional intelligence and probelm solving skills
it will prevent you from ruminating
low-dose clomipramine + low-dose selegiline + bromantane to be in a better state overall
agomelatine also helps
I appreciate your honesty and thanks for your thoughts on the third item.
David Gandy
New Member
im not
