(US) Long term stash planning BIG Thread

I dont think its overblown at all the bar us set so low on sterility its laughable. I run sterility testing to the letter its says in USP71 and Lal gel clot tests for endotoxins. Your skin and digestive system are natural barriers when you stick a needle in yourself all bets are off. But your all big boys
I've always learned that the proof is in the pudding. 1000s of injections later among 100.000s of users with an extremely low incidence of infections tells me the products are sterile enough. Some contamination is to be expected if you'd inspect every single vial, but it doesn't automatically mean it will cause you any significant harm.
 
I've always learned that the proof is in the pudding. 1000s of injections later among 100.000s of users with an extremely low incidence of infections tells me the products are sterile enough. Some contamination is to be expected if you'd inspect every single vial, but it doesn't automatically mean it will cause you any significant harm.
Access and fever are not the only types of infections. You can get fungal infections on your organs that leach slowly without you knowing that antibiotics cant treat. Sepsis that can kill you. *Staphalacoccus aureus* mutations like MRSA that very commen on the skin flora of about 25% of the population.
 
Access and fever are not the only types of infections. You can get fungal infections on your organs that leach slowly without you knowing that antibiotics cant treat. Sepsis that can kill you. *Staphalacoccus aureus* mutations like MRSA that very commen on the skin flora of about 25% of the population.
yep, fearmongering. In theory you are right. But in the real world it hardly ever happens.
 
On that note & to pre-empt the bubble boys, I’ve used well in excess of 1,000 pharma amps over the last 20 years & not once have I used a filter needle & I’ve had zero issues from doing so.
When I used to homebrew, and I wanted to make myself small quantities like 1-5 vials of a special blend / rare compound, I didn't even bother filtering after doing it for a few years.

Never got an infection from pinning my own unfiltered gear.
 
When I used to homebrew, and I wanted to make myself small quantities like 1-5 vials of a special blend / rare compound, I didn't even bother filtering after doing it for a few years.

Never got an infection from pinning my own unfiltered gear.
junkies filter dope through dirty cigarette filters and reuse needles and manage to not OD on fentynol constantly. Doesn't mean its safe because some get away with it. And not filtering at all with Chinese raws is crazy.
 
Sure, but if the rhetoric present in public discourse is only ever "you'll die/get an infection if you don't filter gear", people might start to believe that.

My N=1 data is that across hundreds of unfiltered pins, infections = 0
Across thousands of filtered pins, infections requiring hospitalization = 5
 
Sure, but if the rhetoric present in public discourse is only ever "you'll die/get an infection if you don't filter gear", people might start to believe that.

My N=1 data is that across hundreds of unfiltered pins, infections = 0
Across thousands of filtered pins, infections requiring hospitalization = 5
I never said you will always get and infection or die. But you could and a steroid user will do thousands of injections and luck always runs out. I dont care someone does it personally if they understand the risk but having the opinion you should do it properly shouldn't be tossed out as loonisy. I do believe if your packaging it for sale not personal use you have a higher responsibility to do it right .
 
I never said you will always get and infection or die. But you could and a steroid user will do thousands of injections and luck always runs out. I dont care someone does it personally if they understand the risk but having the opinion you should do it properly shouldn't be tossed out as loonisy.
Show me where we did that.
 
I never said you will always get and infection or die. But you could and a steroid user will do thousands of injections and luck always runs out. I dont care someone does it personally if they understand the risk but having the opinion you should do it properly shouldn't be tossed out as loonisy. I do believe if your packaging it for sale not personal use you have a higher responsibility to do it right .
I'm a little bit lost on what we're exactly discussing. If refiltering china gear, I don't see the point, but if there ade visible floaters, by all means. If it's about homebrewing, of course ffs use a filter! If peptides, waste of time and money but there might be long term benefits that we just don't know yet. Will filtering make steroids and peptides safe? No.
 
I think we're overlooking the fact here a finished product is filtered and suspended in solvents such as BA which is a bacteriostatic and helps keep the product "sterile".

Yes, infections can occur during pinning..As other point out they are relatively rare. From a statistical odds perspective; is it's more likely that infection was cause by production being without a laminar hood (but otherwise hygienic environment) or poor injection prep/technique by the user? Many users get complacent and do not clean the injection site prior to pinning... As you said, many bugs exists on our skin fauna...

I'm not saying contamination isn't an issue when replacing the stopper.... I'm highlighting that you can mitigate that risk sufficiently with a clean & disinfected workspace and good hygiene (use of proper skin scrubs, impervious apron, sterile gloves, hair net or containment if really necessary) To be honest for a quick procedure like changing a single stopper some sterile gloves would probably be sufficient.

All these pages talking about use of laminar hoods..very little on safe injection technique...my point about missing the bigger picture
 
I think we're overlooking the fact here a finished product is filtered and suspended in solvents such as BA which is a bacteriostatic and helps keep the product "sterile".

Yes, infections can occur during pinning..As other point out they are relatively rare. From a statistical odds perspective; is it's more likely that infection was cause by production being without a laminar hood (but otherwise hygienic environment) or poor injection prep/technique by the user? Many users get complacent and do not clean the injection site prior to pinning... As you said, many bugs exists on our skin fauna...

I'm not saying contamination isn't an issue when replacing the stopper.... I'm highlighting that you can mitigate that risk sufficiently with a clean & disinfected workspace and good hygiene (use of proper skin scrubs, impervious apron, sterile gloves, hair net or containment if really necessary) To be honest for a quick procedure like changing a single stopper some sterile gloves would probably be sufficient.

All these pages talking about use of laminar hoods..very little on safe injection technique...my point about missing the bigger picture
You supposedly work in sterile compounding and your attitude is this blasé? Makes me doubt your legitimacy honestly.

Personally I’d never expose filtered particle free oil to particle laden air.

All those injected particles add up inside your body and can’t be removed. So minimising them is prudent.

Why be lazy and take chances with your health.
 
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You supposedly work in sterile compounding and your attitude is this blasé? Makes me doubt your legitimacy honestly.

Personally I’d never expose filtered particle free oil to particle laden air.

All those injected particles add up inside your body and can’t be removed. So minimising them is prudent.

Why be lazy and take chances with your health.

I'm just being practicable about the matter. UGL gear is almost exclusively not made in an isolator or under a mini-cube. I've seen photos of a fair few labs, they're generally using kitchen glassware, not borosilicate lab ware - let alone a mini cube. They are "sterilising" (for want of a better word) via filtering and use of solvents.

My point is; if you're replacing 1 or 2 stoppers the investment in a mini-cube is not necessary. If you were going to making large quantities, or performing task with frequency, then yes. But £££ investment for replacing a handful of stoppers. No. Ridiculous.

I mean if you were that concerned you could refilter after changing the stopper. That's way more practicable for a one off small task than buying a mini-cube.
 
I'm a little bit lost on what we're exactly discussing. If refiltering china gear, I don't see the point, but if there ade visible floaters, by all means. If it's about homebrewing, of course ffs use a filter! If peptides, waste of time and money but there might be long term benefits that we just don't know yet. Will filtering make steroids and peptides safe? No.
Filtration isnt about making the product safe all the way around its 1 step removing microorganisms and their spores . And even that does nothing for LPS ( endotoxin) then you gotta worry about heavy metal contamination and HPLC nor GCMS can tell that you need ICP MS and thats only gonna be at a big certified lab that wont touch unregulated APis that are controlled substances. Unless you send it in with one of those kits labeled a dietary supplement. But regardless I dont see a reason to scoff at the idea of being careful let everyone have there opinion and debate why you feel that way and let everyone make their own decisions. But Im not gonna shame someone for suggesting proper procedures because Im one of the super carefull ones that goes by the book . I know you would give me shit about being paranoid I run sterility test environmental monitoring bioburden assays on APIs .
 
Ah, last time I tried to buy them it said ‘backorder’ and they never got back to me about restocking. I assumed since they were expired it seemed unlikely to get more in stock.
Dunno if it helps, but placed another order a while ago and they were 'backordered' but ended up shipping in a couple days, so I'm guessing they are in somewhat constant supply.
 
I'm just being practicable about the matter. UGL gear is almost exclusively not made in an isolator or under a mini-cube. I've seen photos of a fair few labs, they're generally using kitchen glassware, not borosilicate lab ware - let alone a mini cube. They are "sterilising" (for want of a better word) via filtering and use of solvents.

My point is; if you're replacing 1 or 2 stoppers the investment in a mini-cube is not necessary. If you were going to making large quantities, or performing task with frequency, then yes. But £££ investment for replacing a handful of stoppers. No. Ridiculous.

I mean if you were that concerned you could refilter after changing the stopper. That's way more practicable for a one off small task than buying a mini-cube.
I was mainly talkimg about not filtering brew and saying a hood was unnecessary for aseptic compounding . Why would you change the stopper to begin with unless you suspect they used low quality silicone shit that will break down in the product . And how you gonna sterilize the stoppers please dont say 70% IPA because thats hardly good enough . Way better off just transferring them into better quality pre sterile sealed vials. I dont even touch stoppers when Im double gloved I use forceps and flame them with a bunson burner everytime I set them down.
 
I was mainly talkimg about not filtering brew and saying a hood was unnecessary for aseptic compounding . Why would you change the stopper to begin with unless you suspect they used low quality silicone shit that will break down in the product . And how you gonna sterilize the stoppers please dont say 70% IPA because thats hardly good enough . Way better off just transferring them into better quality pre sterile sealed vials. I dont even touch stoppers when Im double gloved I use forceps and flame them with a bunson burner everytime I set them down.

Erm - this whole conversation started because someone was talking about replacing the stopper!

Not filtering a brew is ridiculous. A hood isn't necessary for asceptic compounding; an isolator is - but that's me being a dick. I get what you're saying.

If you're going to the extent of brewing at home, yes, I would agree buying a mini-cube would be a worthy investment. But again, this was all about someone replacing a stopper on a vial.
 
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