Tirzepatide vs Retatrutide appetite suppression strength

[Dhtcoper123]

I’m currently on reta, and I’m wondering, from anyone who’s used both, how is the difference in appetite suppression strength between it and tirz? Lets say I’m on 5mg reta, what dose would roughly be equivalent to that in terms of appetite suppression with tirz? I know it’s probably individual, but in your experience how was it?

 

[ostrichsak]

Tirz certainly has a higher impact to the GLP1 receptors. Not as much as Semaglutide but certainly far more than Reta which, of the three agonists, the GLP1 is the weakest of the bunch. Hard to say how much, since everyone is different.

I'll assign an arbitrary # to it though to give you an idea but the hunger suppression of Tirz is at least 50% greater than that of Reta whereas Sema may be 100% greater than Reta & 50% more than Tirz.

Again, all arbitrary #'s but just to assign some sort of metric for conversations sake.

I've seen some people add in a little Tirz once per week at a start very low dose (if you got this route) strictly for the satiety effect. There was also some well-known "oops" scenarios where they were combined at the lab that were found in 3rd part testing (subtle reminder to test your peptides). I still think that this may have been more of a requested stack that got mislabeled or something along those lines more so than I think it was a legitimate mix-up by the labs.

Using a little Tirz w/Reta as the primary weight loss peptide may result in a lower Glucagon agonist (since you likely wouldn't be dosing Reta as high to titrate for weight loss if you're getting those other two agonist as overlap from Tirz also) so while it's common, I'm not sure it's the best way to go. Maybe for some though.

You can also check into Cagrilintide as well. This may be a better option if all you want is the satiety effects since Tirz will not only be adding a stronger GLP1 agonist to Reta but it will also increase the GIP agonist as well. Common dosage for this use is 1.5mg sub-Q once per week. I'd suggest starting with 500mcg though to see if that gets the desired effect.

Keep in mind that the half life of Cagri is about a week so it takes about a month of weekly injections to reach a steady-state in your system. It's best to give it a month to reach this level to see if it has the desired effect on hunger. If not, move up to 1mg and finally 1.5mg per week, if needed. You can go up from there but I'd take smaller steps and give the increased dose time to reach a steady state each time.

 

[Dhtcoper123]

Tirz certainly has a higher impact to the GLP1 receptors. Not as much as Semaglutide but certainly far more than Reta which, of the three agonists, the GLP1 is the weakest of the bunch. Hard to say how much, since everyone is different.

I'll assign an arbitrary # to it though to give you an idea but the hunger suppression of Tirz is at least 50% greater than that of Reta whereas Sema may be 100% greater than Reta & 50% more than Tirz.

Again, all arbitrary #'s but just to assign some sort of metric for conversations sake.

I've seen some people add in a little Tirz once per week at a start very low dose (if you got this route) strictly for the satiety effect. There was also some well-known "oops" scenarios where they were combined at the lab that were found in 3rd part testing (subtle reminder to test your peptides). I still think that this may have been more of a requested stack that got mislabeled or something along those lines more so than I think it was a legitimate mix-up by the labs.

Using a little Tirz w/Reta as the primary weight loss peptide may result in a lower Glucagon agonist (since you likely wouldn't be dosing Reta as high to titrate for weight loss if you're getting those other two agonist as overlap from Tirz also) so while it's common, I'm not sure it's the best way to go. Maybe for some though.

You can also check into Cagrilintide as well. This may be a better option if all you want is the satiety effects since Tirz will not only be adding a stronger GLP1 agonist to Reta but it will also increase the GIP agonist as well. Common dosage for this use is 1.5mg sub-Q once per week. I'd suggest starting with 500mcg though to see if that gets the desired effect.

Keep in mind that the half life of Cagri is about a week so it takes about a month of weekly injections to reach a steady-state in your system. It's best to give it a month to reach this level to see if it has the desired effect on hunger. If not, move up to 1mg and finally 1.5mg per week, if needed. You can go up from there but I'd take smaller steps and give the increased dose time to reach a steady state each time.

Ok, thanks for giving me a general idea! My problem is, I have a good deal on a kit of 30mg vials of tirz, but I don’t know if I will be able to use them up in time. I know that in general reconstituted peptides should only be used for 6 weeks. I just don’t know if I will be able to use 5mg a week haha. I’m currently on 5mg of reta and pretty suppressed. Worst case scenario I’ll have to just throw away whats remaining after the 6 weeks mark I guess. If GLP 1s don’t have some sort of longer shelf life I don’t know about but I doubt that.

 

[ostrichsak]

Ok, thanks for giving me a general idea! My problem is, I have a good deal on a kit of 30mg vials of tirz, but I don’t know if I will be able to use them up in time. I know that in general reconstituted peptides should only be used for 6 weeks. I just don’t know if I will be able to use 5mg a week haha. I’m currently on 5mg of reta and pretty suppressed. Worst case scenario I’ll have to just throw away whats remaining after the 6 weeks mark I guess. If GLP 1s don’t have some sort of longer shelf life I don’t know about but I doubt that.

The official USP guidance is 28 days. Understand that your "6 weeks" is alreayd blowing pas that by 50% so it's not something to be taken lightly. That doesn't mean that I personally haven't gone past that but my process is iron clad. I buy from good sources and 3rd party test. That doesn't do much for contaminants though but the hope is that if the masses are good and they test well that the labs process hopefully involves top tier sterility protocols. It certainly doesn't guarantee it though.

I then filter using individually wrapped USP certified filters and use only USP certified vials to filter my peptides into. I also then keep them dark and refrigerated 100% unless I'm drawing to inject. When I draw I use proper sterility and cleaning protocols as well.

Assuming you're doing all of that... you can start taking more freedoms with that 28-day rule with slightly lowered risk. But the risk is always there. I'm fine with people pushing that timeline but it's improtant that they fully understand the risks associated and take every precaution within their power to keep things as safe as possible.

If you're cutting corners and buying peptides that are too large because the price is good you're going to end up in the hospital or worse to save ten or twenty bucks. Not very wise.

Choose your peptide weight based on the best "deal" is a poor plan. Always determine what your dose will be, try to project what it may be in situations where a titration is part of the plan (Reta & Tirz, for instance) and then find the best deal on the actual size you need. If you go for the lowest price per mg you'll end up with a 50mg+ vial that lasts you 8-9 months on your starting protocol. You'll throw over half of it out and even wasting all of that will likely still have you in a high risk timeframe for months.

I'd highly recommend that you don't do it. Throw the lyophilized powder in the freezer and get a proper size vial. 10mg is ideal if you're just starting out as you'll (likely) be on 1mg per week for the first month and titrating up to 1.5-2mg the 2nd month. Get yourself a 10mg vial and then plan to go to 15mg or maybe a 20mg the 2nd phase.

I sure hope you're not starting out on 5mg per week as your first time using a GLP1 peptide. Your 2nd post made it sound like that may be the case. If so, you're getting some terrible advice.

 

[subkieran]

Reta shows no sign of significant degredation even past 90 days. Only thing that might happen is that the potency decreases.
Same goes for other peptides. If you are using a sterile environment and bac water, peptides in general will not degrade significantly (one could argue HGH as the exemption).

 

[Deezznutzz]

I had the opposite results. Tirz appetite suppression is way stronger than Sema. Have not tried reta yet.

 

[Athleticfreak]

Ok, thanks for giving me a general idea! My problem is, I have a good deal on a kit of 30mg vials of tirz, but I don’t know if I will be able to use them up in time. I know that in general reconstituted peptides should only be used for 6 weeks. I just don’t know if I will be able to use 5mg a week haha. I’m currently on 5mg of reta and pretty suppressed. Worst case scenario I’ll have to just throw away whats remaining after the 6 weeks mark I guess. If GLP 1s don’t have some sort of longer shelf life I don’t know about but I doubt that.

You can use reconstituted Tirz for 90 days or more. There have been potency test and degradation test on it. Make sure you’re using Hospira bac water.

 

[ostrichsak]

Reta shows no sign of significant degredation even past 90 days. Only thing that might happen is that the potency decreases.
Same goes for other peptides. If you are using a sterile environment and bac water, peptides in general will not degrade significantly (one could argue HGH as the exemption).

You may be conflating a couple of things here. The risk with going beyond 28 days has very little to do with degradation. Once you reconstitute, you're on the clock for dangerous levels of bacteria/endotoxins. These grow over time and eventually reach a level that they're dangerous.

This is the reason for using bacteriostatic water as the 0.09% isopropyl alcohol in it helps to inhibit the growth of bad things. Refrigeration further slows the growth. This is why if you're injecting the entirety of the contents of a vial immediately after reconstitution it's safe to use sterile water and not worry about refigeration.

All of those steps we take for reconstituted peptides are 99% for bacterial growth and less than 1% because of degradation. The danger is in the harm that can come from using reconstituted peptides beyond 28 days, not the lack of efficacy.

The time to care about degradation is more when it's in it's lyophilized form and the goal is long term storage. This is why we freeze it which extends it's life into the decades. Not for bacterial growth but for degradation. Once we reconstitute it there's a much faster clock on it due to becomming dangerous.

I think there's some misinformation out there on the "why" behind the 28 day official stance of the USP and a lot of people are making risking decisions based on bad intel thinking it's like an ibuprofen that just has slightly lower efficacy years after it's expiration date but no other harm to be had. Water-based peptides are a different thing entirely and the dangers are real.

 

[ostrichsak]

You can use reconstituted Tirz for 90 days or more. There have been potency test and degradation test on it. Make sure you’re using Hospira bac water.

Again, the concern isn't about potency/degradation. If there were any bacteria or endotoxins present (assume there were) during the manufacturing process you're giving it time to replicate.

They replicate faster at room temp, slower when refrigerated but replicating none-the-less. Many factors at play here including the bac water used, if the peptide(s) has been filtered, if the vial was then refrigerated, if proper cleaning protocol was followed each time the vial was accessed, etc.

Not saying you can't go 90 days on your reconstituted Tirz, what I'm saying is that it's important to understand what the actual risk is so that you can make an informed decision. It's a different conversation when you're weighing a slight reducing in efficacy to cost versus your health and potentially highly dangerous systemic sickness and/or infection against the cost.

Personally, I take all of the necessary steps on the front end which makes me comfortable to take the vial to 60 days. In that third month though, I'm doing math on how much money I'd be throwing out to just chuck it. Often times my health and safety isn't worth the fistful of dollars. Properly size on the front end and this is a non-issue.

 

[ostrichsak]

You may be conflating a couple of things here. The risk with going beyond 28 days has very little to do with degradation. Once you reconstitute, you're on the clock for dangerous levels of bacteria/endotoxins. These grow over time and eventually reach a level that they're dangerous.

This is the reason for using bacteriostatic water as the 0.09% isopropyl alcohol in it helps to inhibit the growth of bad things. Refrigeration further slows the growth. This is why if you're injecting the entirety of the contents of a vial immediately after reconstitution it's safe to use sterile water and not worry about refrigeration.

All of those steps we take for reconstituted peptides are 99% for bacterial growth and less than 1% because of degradation. The danger is in the harm that can come from using reconstituted peptides beyond 28 days, not the lack of efficacy.

The time to care about degradation is more when it's in it's lyophilized form and the goal is long term storage. This is why we freeze it which extends it's life into the decades. Not for bacterial growth but for degradation. Once we reconstitute it there's a much faster clock on it due to becoming dangerous.

I think there's some misinformation out there on the "why" behind the 28 day official stance of the USP and a lot of people are making risking decisions based on bad intel thinking it's like an ibuprofen that just has slightly lower efficacy years after it's expiration date but no other harm to be had. Water-based peptides are a different thing entirely and the dangers are real.

Quoting myself as I seem to have made a couple of mistakes I want to correct and realized it just past the 30min cap on post edits this forum has:

I meant to say 0.9% Benzyl alcohol in this post. A little bit early to be typing up novels like this, apparently. Some Amazon BAC water may only have 0.09% Benzyl Alcohol but Hospira by Pfizer has the correct ratio.

Hell, I've seen sketchy Amazon BAC water that was tested that ended up having cleaning solvents instead of Benzyl Alcohol. Yikes! At least they got the 0.9% ration correct though.