SLU-PP-332 Solution Discussion

[actionjackson6699]

alright thank you, What oil would work? i tried dmso and destilated water but that didnt worked.

How are you mixing them? The way you mix matters. Supposedly some folks are using dmso + water. I currently use mig840 but any oil should work if you heat it first and keep it moving then very slowly drip the concentrated DMSO stock solution into it. That being said synthetic solvents like peg400 + PG should also work at low concentrations (like 1.5mg/ml) they would probably be the easiest to mix. Kimera chems sells an injectable that uses those solvents without DMSO. Lots of oral sarms are sold using those solvents as well, I would take those before taking 100% DMSO daily, less risk of pulling in some other toxins.

 

[actionjackson6699]

For their oral mixes seems like kimera uses DMSO + peg400. Would probably be the absolute easiest to way to get it into an oral solution at high concentration.

 

[ThreeSix]

would it also dissolve in vg/pg? 50:50?

 

[mongo5165]

I bet something like this might work as well

SuspendRx™ Anhydrous Oral Suspension Vehicle (Sweetened) | Sweetened — SpecializedRx SuspendRx™ Anhydrous Oral Suspension Vehicle (Sweetened)

 

[actionjackson6699]

Has no one else experimented with making a stable injectable solution? My longest stable formula has been. SLU at 6mg/mg + Poloxamer 188 at 5mg/ml (a surfactant that keeps the slu from recrystallizing) using 1%BA + 8%DMSO + 20%BB + 36%MiG840 + 35%EO. Makes a hazy solution due to the polox but its been room temp stable for months. It should filter fine but remain hazy due to the polox. I think there is too much polox and need to try lowering that a bit. I have also used a simpler 8%DMSO + 1%BA + 15%BB + 76%MiG840 solution and its clear and filters initially but over time when using it the slu starts crystallizing and sticking to the sides of the vial and you need to run the vial through a sonicator cycle or two to get it clear again which is annoying. Have been dosing 1-3mg of slu this way morning and night and its a smooth pin with no pip.

 

[Photon]

Has no one else experimented with making a stable injectable solution? My longest stable formula has been. SLU at 6mg/mg + Poloxamer 188 at 5mg/ml (a surfactant that keeps the slu from recrystallizing) using 1%BA + 8%DMSO + 20%BB + 36%MiG840 + 35%EO. Makes a hazy solution due to the polox but its been room temp stable for months. It should filter fine but remain hazy due to the polox. I think there is too much polox and need to try lowering that a bit. I have also used a simpler 8%DMSO + 1%BA + 15%BB + 76%MiG840 solution and its clear and filters initially but over time when using it the slu starts crystallizing and sticking to the sides of the vial and you need to run the vial through a sonicator cycle or two to get it clear again which is annoying. Have been dosing 1-3mg of slu this way morning and night and its a smooth pin with no pip.

It doesn't crystalise, it precipitates out of the solution because it can't actually hold it. Solubality data can be found on this page but it's usually too optimistic. The reality is that it's usually lower that what's listed. Personally I'd rather inject a suspension than one with dmso. The only solvent doing any work is the DMSO.

I don't use slu so I can't comment about anything else.

SLU-PP-332 | Estrogen/progestogen Receptor agonist | CAS 303760-60-3 | Selleck

SLU-PP-332 is an agonist of pan-<b>Estrogen Receptor</b>/ERR with EC50 values of 98nM, 230nM, and 430 nM for ERRα, ERRβ, and ERRγ, respectively with the highest potency for ERRα. SLUPP-332 amplifies mitochondrial function and cellular respiration in skeletal muscle cell lines and also offers...

www.selleckchem.com

 

[actionjackson6699]

It doesn't crystalise, it precipitates out of the solution because it can't actually hold it. Solubality data can be found on this page but it's usually too optimistic. The reality is that it's usually lower that what's listed. Personally I'd rather inject a suspension than one with dmso. The only solvent doing any work is the DMSO.

I don't use slu so I can't comment about anything else.

SLU-PP-332 | Estrogen/progestogen Receptor agonist | CAS 303760-60-3 | Selleck

SLU-PP-332 is an agonist of pan-<b>Estrogen Receptor</b>/ERR with EC50 values of 98nM, 230nM, and 430 nM for ERRα, ERRβ, and ERRγ, respectively with the highest potency for ERRα. SLUPP-332 amplifies mitochondrial function and cellular respiration in skeletal muscle cell lines and also offers...

www.selleckchem.com

It can hold it, it's just not stable. If it couldn't hold it, It would just crash out of solution rapidly.. also sonication would not make it clear again. The crystals are slowly forming over weeks...not immediately.

I prefer accurate dosing to randomly dosing using a suspension. By the end of the vial your probably just injecting oil. Keep your DMSO clean (which you should do with anything you're injecting) and your shouldn't have issues...it's only 8% after all ..

 

[Photon]

It can hold it, it's just not stable. If it couldn't hold it, It would just crash out of solution rapidly.. also sonication would not make it clear again. The crystals are slowly forming over weeks...not immediately.

I prefer accurate dosing to randomly dosing using a suspension. By the end of the vial your probably just injecting oil. Keep your DMSO clean (which you should do with anything you're injecting) and your shouldn't have issues...it's only 8% after all ..

Sonicate your suspension before each injection

 

[actionjackson6699]

Sonicate your suspension before each injection

Still won't be the same as using DMSO. It will not be clear. Maybe with some thick ass castor oil it will stay uniform enough to get a syringe filled. But I prefer a nice 31g insulin syringe.

 

[vapor77]

Personally I'd rather inject a suspension than one with dmso.

How would you go about making an injectable suspension with this?

MCT + BA and just shake every time?

I've only made oral suspensions and injectable solutions.

 

[Walter Hype]

i got mine to hold at 6mg using castor and 6% dmso none issue and it never crashes either using 20% bb on top nothing else. crystal clear too. though i find any moisture in any part of this process will change that big time. dry ingredients work the best here even water in your air can fuck it up

 

[actionjackson6699]

How would you go about making an injectable suspension with this?

MCT + BA and just shake every time?

I've only made oral suspensions and injectable solutions.

Doub

i got mine to hold at 6mg using castor and 6% dmso none issue and it never crashes either using 20% bb on top nothing else. crystal clear too. though i find any moisture in any part of this process will change that big time. dry ingredients work the best here even water in your air can fuck it up

What concentration of SLU/ml? What length of time staying in solution?

 

[Photon]

i got mine to hold at 6mg using castor and 6% dmso none issue and it never crashes either using 20% bb on top nothing else. crystal clear too. though i find any moisture in any part of this process will change that big time. dry ingredients work the best here even water in your air can fuck it up

In the above link



6% gets you around 3.5mg/ml, the rest is probably suspended. it may be so fine that its not visible, or maybe it actually dissolved during sonification, no clue really. But if u did however push through a .22um and it tested at 6mg/ml then it probaby did dissolve.

This website claims 100mg/ml in DMSO with ultrasonic lol.

https://www.medchemexpress.com/slu-pp-332.html?locale=ja-JP

The numbers are all over the place, i guess someone needs to test and figure it out.

 

[Walter Hype]

In the above link
View attachment 380876
View attachment 380877

6% gets you around 3.5mg/ml, the rest is probably suspended. it may be so fine that its not visible, or maybe it actually dissolved during sonification, no clue really. But if u did however push through a .22um and it tested at 6mg/ml then it probaby did dissolve.

This website claims 100mg/ml in DMSO with ultrasonic lol.
View attachment 380880

https://www.medchemexpress.com/slu-pp-332.html?locale=ja-JP

The numbers are all over the place, i guess someone needs to test and figure it out.

i have no clue honestly i do ultrasonic push it and its never crashed after that and only after that did i filter and it still looks clear on BOTH ends, maybe this is a a conservative estimate? sometimes data like this is very limited. in any case many people love my slu and have gotten very strong effects. i always wondered how people push higher than 6mg and like you said it can be just suspended? hmmm

 

[Walter Hype]

In the above link
View attachment 380876
View attachment 380877

6% gets you around 3.5mg/ml, the rest is probably suspended. it may be so fine that its not visible, or maybe it actually dissolved during sonification, no clue really. But if u did however push through a .22um and it tested at 6mg/ml then it probaby did dissolve.

This website claims 100mg/ml in DMSO with ultrasonic lol.
View attachment 380880

https://www.medchemexpress.com/slu-pp-332.html?locale=ja-JP

The numbers are all over the place, i guess someone needs to test and figure it out.

as mentioned water ruins its potential ANY Water and i mean ANY FREAKING WATER makes slu crash out Hard i had to vacuum dry my dmso for one hour to actually get it to work. i also had to run my dehumidified in my environment to push humidity down to 30% this compound is not your typical brewing. its very sensitive. you might as well vacuum dry the raws too. once things are very dry dmso holds it and the oil. never crashes. but if i leave a media bottle open at all it crashes out but once its sealed in vials its fine.

 

[actionjackson6699]

i have no clue honestly i do ultrasonic push it and its never crashed after that and only after that did i filter and it still looks clear on BOTH ends, maybe this is a a conservative estimate? sometimes data like this is very limited. in any case many people love my slu and have gotten very strong effects. i always wondered how people push higher than 6mg and like you said it can be just suspended? hmmm

So with dry DMSO + oil it has remained stable in the vial for months? Even after the vial is punctured, swabbed with 70% alcohol and used?

 

[Walter Hype]

So with dry DMSO + oil it has remained stable in the vial for months? Even after the vial is punctured, swabbed with 70% alcohol and used?

yep! well theres not alot of data long term i havent had it MONTHS lol only 3 months ish., but its stable. lets see long term. but ill be pushing for 10mg one more time to see if i can get it to hold this time around. profits on it are nice and its worth fine tuning it to stand out more but i cant stand to go more on dmso.

 

[Walter Hype]

So with dry DMSO + oil it has remained stable in the vial for months? Even after the vial is punctured, swabbed with 70% alcohol and used?

alot of the dmso on the market is ASS and if it smells strong of garlic you got BAD dmso you either vaccum it and suck it out or get proper glass contained dmso in DARK amber container. make sure they have proof they purified it.

if you got the equipment you can purify your own dmso but if you dont have a way to vent the stuff it will ruin your room .....so be warned the smell once extracted is deadly strong