MESO-Rx

Anabolic Steroids

Safinamide – a clean dopamine booster that actually makes sense?

Deadpool99 said:
Appreciate it, thanks again for all the help.
Click to expand...
You're welcome. Now come back in a few days, with your findings about Memantine, because believe it or not - I figured that drug out in less 20 minutes before I had asked you about it. Having toyed around with this topic enough, I just had to put 2 and 2 together. What I quoted was just the results of maybe half a dozen prompts into this subject. I am sure there is more to find, but I am just a retard with a computer and internet access.
I just never cared about managing the mental side effects of Tren, because they don't affect me.
 
Banana Joe said:
You're welcome. Now come back in a few days, with your findings about Memantine, because believe it or not - I figured that drug out in less 20 minutes before I had asked you about it. Having toyed around with this topic enough, I just had to put 2 and 2 together. What I quoted was just the results of maybe half a dozen prompts into this subject. I am sure there is more to find.
I just never cared about managing the mental side effects of Tren, because they don't affect me.
Click to expand...
Personally I don’t think it’s the tren is the causation of my low energy, it actually started in a period where I stopped tren. So the goal was to improve my energy/motivation without having a crash/insomnia and safe alongside any stims.

Some pointed out KSM-66 could have fucked me, made sense cuz it is quite sedating, took it out and saw some improvement but I felt like I could do better.

Which landed me to this compound, the fact that it could counteract tren was just one of my findings, it wasn’t specifically what I was looking for.

Cuz I swear to you, I cannot tell the difference between using 0 vs 680mg tren, from a mental/physical and even a bloodwork POV. My bloods have been great to the point I started testing my tren via jano just in case.
 
Banana Joe said:
"Phenibut is considered highly addictive, with evidence indicating a significant potential for dependence, tolerance, and withdrawal, even with relatively short-term or low-dose use."
Click to expand...
I fully agree, and to me it is one you have to weigh the risk vs reward. Phenibut while it can be addictive is great no more then two times a week. I do have an “addictive personality” if you want to call it that, with alcohol, but I understand the consequences of misusing the compound and in the past 8 years have had no issues. For me, it does wonders on all end, mood, sociability, sleep, etc. I fully agree it is not for everyone as well, but for those who can have full control of amountxfequency it is taken, it is one of the better things I have ever tried. Forewarning, the withdrawals are said to those of hell, some said similar to H, so again, not for everyone but maybe some. That is my view on it
 
imthankful said:
I fully agree, and to me it is one you have to weigh the risk vs reward. Phenibut while it can be addictive is great no more then two times a week. I do have an “addictive personality” if you want to call it that, with alcohol, but I understand the consequences of misusing the compound and in the past 8 years have had no issues. For me, it does wonders on all end, mood, sociability, sleep, etc. I fully agree it is not for everyone as well, but for those who can have full control of amountxfequency it is taken, it is one of the better things I have ever tried. Forewarning, the withdrawals are said to those of hell, some said similar to H, so again, not for everyone but maybe some. That is my view on it
Click to expand...
I also take mega-dose Phenibut every Sat/Sun for the last 10 years
 
Banana Joe said:
"Phenibut is considered highly addictive, with evidence indicating a significant potential for dependence, tolerance, and withdrawal, even with relatively short-term or low-dose use."
Click to expand...
Exactly my take when I saw it, but I didn’t want to comment again without any experience on it.
 
ChemBB said:
I also take mega-dose Phenibut every Sat/Sun for the last 10 years
Click to expand...
Love it. I try to split it like Tuesday/Saturday, typically my busiest days. Average 2-3g each time with 6.5g being the most I have taken. I think the upper limit is 4g with no noticeable benefit for me. Though, I will be at 3x this week dosing today and tmwr for hunting
 
Duke309 said:
What do you consider a mega dose? You doing this for social settings or for sleep?
Click to expand...
Personally, 4grams for me. I remember reading over 6 in a dose can be stressful on the liver. However over the past year I reversed my fatty liver without limiting my use, so I think you would have to be taking huge amounts frequently to cause any stress, or in addition to other compounds
 
I don’t know about you guys but adderall is the best for dopamine boosting
I’m on and off from it and it’s amazing
I guess I can control myself when it comes to addicting substances also best pre you can take
 
Duke309 said:
What do you consider a mega dose? You doing this for social settings or for sleep?
Click to expand...
I take about 4g IIRC, my doses are almost identical to @imthankful

I was a polysubstance drug addict for many years, sober now for ~6-7 years, and Phenibut on weekends + daily 6-7g Kratom (which I don't really even feel anymore unfortunately) are the one thing I "allow" myself, because total abstinence doesn't work for me.

(Cravings just build up over time until eventually after a few months I binge really hard on something)

6g is my limit, if I go to 7g I overdose and will violently vomit nonstop for 7-8 hours with the worst nausea I've ever had in my life

Learned this from experience by making this mistake not once, but 3 times, LMAO

(Do NOT read this and assume 4g is a "good" dose for someone without years of Phenibut tolerance to take. You will OD, and you will regret it.)
 
I can't really follow, what do amphetamines and opoid-like substances have to do with the OP's intended purpose?

Deadpool99 said:
I guess also when you research and the AI throws the word neuro-protective, my curiosity is automatically triggered.
Click to expand...
Wanna go down another rabbit-hole? I bet you didn't expect me to come up with DNP, or did you?

DNP at around 0.03 to 0.07 mg/kg is apparently neuro-protective as well. Some people seem take around 1-2mg against brain-fog, or as a nootropic.

AI said:
Memantine protects the brain mainly by blocking excessive NMDA receptor activity linked to glutamate excitotoxicity, helping to normalize brain signaling and reduce neuronal damage. Low dose DNP also offers neuroprotection but works through mild mitochondrial uncoupling that reduces oxidative stress and mitochondrial calcium overload. Both mechanisms help protect neurons and could theoretically mitigate mental side effects from trenbolone, with memantine acting on glutamate pathways and DNP on mitochondrial function. In short, memantine modulates excitotoxicity via NMDA receptors, while low dose DNP protects by improving mitochondrial resilience. Both have neuroprotective potential but work through different pathways.
Click to expand...

www.sciencedirect.com

Protective effects of 2,4-dinitrophenol in okadaic acid-induced cellular model of Alzheimer's disease

Alzheimer's disease (AD) research started several decades ago and despite the many efforts employed to develop new treatments or approaches to slow an…
www.sciencedirect.com www.sciencedirect.com
pubmed.ncbi.nlm.nih.gov

The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation - PubMed

Mitochondrial metabolism is highly responsive to nutrient availability and ongoing activity in neuronal circuits. The molecular mechanisms by which brain cells respond to an increase in cellular energy expenditure are largely unknown. Mild mitochondrial uncoupling enhances cellular energy...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov

2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease - PubMed

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the first exon of the gene huntingtin. There is no treatment to prevent or delay the disease course of HD currently. Oxidative stress and mitochondrial dysfunction have emerged as key determinants of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

2,4 Dinitrophenol as Medicine - PMC

In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950’s to suggest ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Neuroprotective actions of 2,4-dinitrophenol: Friend or foe? - PMC

2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Have fun!
 
Last edited:
Banana Joe said:
Wanna go down another rabbit-hole? I bet you didn't me to come with DNP, or do you?

DNP at around 0.03 to 0.07 mg/kg is apparently neuro-protective as well. Some people seem take around 1-2mg against brain-fog, or as a nootropic.
Click to expand...
Lol, jinx, we posted the same thing at the same time:

ChemBB

Post in thread 'How long can I run DNP?'

Forgot to mention, I've seen a few comments over the years online from people running 75-125mg chronically for mitochondrial/metabolic health.

There are a few papers talking about chronic low-dose DNP use, and some threads with anecdotal experiences

2,4 Dinitrophenol as Medicine - PMC

In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950’s to suggest ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov



...
  • Like
 
ChemBB said:
I take about 4g IIRC, my doses are almost identical to @imthankful

I was a polysubstance drug addict for many years, sober now for ~6-7 years, and Phenibut on weekends + daily 6-7g Kratom (which I don't really even feel anymore unfortunately) are the one thing I "allow" myself, because total abstinence doesn't work for me.

(Cravings just build up over time until eventually after a few months I binge really hard on something)

6g is my limit, if I go to 7g I overdose and will violently vomit nonstop for 7-8 hours with the worst nausea I've ever had in my life

Learned this from experience by making this mistake not once, but 3 times, LMAO

(Do NOT read this and assume 4g is a "good" dose for someone without years of Phenibut tolerance to take. You will OD, and you will regret it.)
Click to expand...
Damn, running kratom daily currently? You could look into 9-Me-BC, I haven’t personally tried it yet - increases tyrosine hydroxylase for mood, motivation, focus, and learning. Could maybe get you off keaton for a longer rest period. To my understanding you are not supposed to have large amounts of sun exposure on it to minimize dna damage, so ideally winter time.

“9-me-BC, or 9-methyl-β-carboline, is a synthetic research chemical that is a derivative of β-carboline and is being studied for its potential effects as a nootropic and neuroprotective agent. It stimulates dopamine production by upregulating an enzyme, inhibits the breakdown of dopamine by inhibiting monoamine oxidase (MAO), and has shown to improve cognitive function, particularly spatial learning, in animal studies. Research also indicates it has neuroregenerative, anti-inflammatory, and neuroprotective properties”
 
Banana Joe said:
I can't really follow, what do amphetamines and opoid-like substances have to do with the OP's intended purpose?


Wanna go down another rabbit-hole? I bet you didn't expect me to come up with DNP, or did you?

DNP at around 0.03 to 0.07 mg/kg is apparently neuro-protective as well. Some people seem take around 1-2mg against brain-fog, or as a nootropic.



www.sciencedirect.com

Protective effects of 2,4-dinitrophenol in okadaic acid-induced cellular model of Alzheimer's disease

Alzheimer's disease (AD) research started several decades ago and despite the many efforts employed to develop new treatments or approaches to slow an…
www.sciencedirect.com www.sciencedirect.com
pubmed.ncbi.nlm.nih.gov

The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation - PubMed

Mitochondrial metabolism is highly responsive to nutrient availability and ongoing activity in neuronal circuits. The molecular mechanisms by which brain cells respond to an increase in cellular energy expenditure are largely unknown. Mild mitochondrial uncoupling enhances cellular energy...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov

2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease - PubMed

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the first exon of the gene huntingtin. There is no treatment to prevent or delay the disease course of HD currently. Oxidative stress and mitochondrial dysfunction have emerged as key determinants of...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

2,4 Dinitrophenol as Medicine - PMC

In the sanctity of pure drug discovery, objective reasoning can become clouded when pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into historical perspective, it was an unorthodox idea in the 1950’s to suggest ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Neuroprotective actions of 2,4-dinitrophenol: Friend or foe? - PMC

2,4-dinitrophenol (DNP) has long been known to be toxic at high concentrations, an effect related to uncoupling of mitochondrial oxidative phosphorylation. Five years ago, however, we reported that low concentrations of DNP protect neurons against ...
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Have fun!
Click to expand...
I was at the brink of using, do I have to now?

Plan to use 250mg on my next cut in 20 weeks.
 
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