Deadpool99
Member
I am have been doing a shit ton of research on mental drive/motivation/mood and possible synergetic compounds with anabolics like tren that offer longer-term brain / CV safety.
Just wanted to share something that might be useful for guys running heavy cycles or anyone dealing with low drive / flat mood without wanting to touch stims.
What it is: (ChatGpt explanation here cuz I don't want to bother spelling it correctly.)
Safinamide is a reversible, selective MAO-B inhibitor that slightly raises dopamine and also tones down excess glutamate. No amphetamine-like stuff, no heart rate spikes, no insomnia. It’s been used in Parkinson’s patients long-term with a really good safety record.
So to my knowledge it seems to:
- Blocks the enzyme that breaks down dopamine which results in steadier levels, better mood and motivation.
- Reduces glutamate over-activity so thus you get less anxiety, irritability, and “wired but tired/followed by crash” feeling.
- Because it’s reversible and only hits MAO-B, there’s no weird diet or stimulant crash.
I plan on trying it, so no anecdotes yet but in theory it should be subtle at first and after a week or two you just do more things without forcing yourself. For example having to get tup walk, do errands and overall be motivated to just get up and do smth/anyth. Energy and focus should feel smoother, not jittery.
Between all the drugs and meds, my main concern was 3 things, QT prolongation, Insomnia risk, issues with BP/HR.
This ticks all the boxes, it doesn’t kill sleep if you take it before noon (even 1 pm is fine if you sleep late like me), it may actually improve sleep.
Why I think it matters for gear users:
Tren and other 19-nors can wreck dopamine balance and crank up glutamate, which is what causes the irritability, anxiety, and brain fog. Safinamide helps level that out and might even be neuroprotective, basically helps your brain tolerate the cycle better.
Dosing data:
50 mg in the morning, can go up to 100 mg if needed.
No taper needed if you stop.
Safety / what to avoid:
only issue is Don’t mix with serotonin-raising stuff (SSRIs, SNRIs, tramadol, MDMA, 5-HTP, St. John’s Wort, etc.).
Otherwise safe with test / tren / mast / GH / heart meds / supplements.
No BP or HR issues, no dependence.
Bottom line:
If you want daily motivation and mood support without stims or sleep issues, this is one of the cleanest things out there. Great add-on if you’re blasting, cruising, or just tired of feeling mentally flat.
Disclaimer:
This was smth that peaked my interest and possibly will experiment with it.
This post is for information only and not medical advice.
Everyone’s medical background and stack are different, do your own research, check for interactions, and get proper labs before starting anything new.
Just wanted to share something that might be useful for guys running heavy cycles or anyone dealing with low drive / flat mood without wanting to touch stims.
What it is: (ChatGpt explanation here cuz I don't want to bother spelling it correctly.)
Safinamide is a reversible, selective MAO-B inhibitor that slightly raises dopamine and also tones down excess glutamate. No amphetamine-like stuff, no heart rate spikes, no insomnia. It’s been used in Parkinson’s patients long-term with a really good safety record.
So to my knowledge it seems to:
- Blocks the enzyme that breaks down dopamine which results in steadier levels, better mood and motivation.
- Reduces glutamate over-activity so thus you get less anxiety, irritability, and “wired but tired/followed by crash” feeling.
- Because it’s reversible and only hits MAO-B, there’s no weird diet or stimulant crash.
I plan on trying it, so no anecdotes yet but in theory it should be subtle at first and after a week or two you just do more things without forcing yourself. For example having to get tup walk, do errands and overall be motivated to just get up and do smth/anyth. Energy and focus should feel smoother, not jittery.
Between all the drugs and meds, my main concern was 3 things, QT prolongation, Insomnia risk, issues with BP/HR.
This ticks all the boxes, it doesn’t kill sleep if you take it before noon (even 1 pm is fine if you sleep late like me), it may actually improve sleep.
Why I think it matters for gear users:
Tren and other 19-nors can wreck dopamine balance and crank up glutamate, which is what causes the irritability, anxiety, and brain fog. Safinamide helps level that out and might even be neuroprotective, basically helps your brain tolerate the cycle better.
Dosing data:
50 mg in the morning, can go up to 100 mg if needed.
No taper needed if you stop.
Safety / what to avoid:
only issue is Don’t mix with serotonin-raising stuff (SSRIs, SNRIs, tramadol, MDMA, 5-HTP, St. John’s Wort, etc.).
Otherwise safe with test / tren / mast / GH / heart meds / supplements.
No BP or HR issues, no dependence.
Bottom line:
If you want daily motivation and mood support without stims or sleep issues, this is one of the cleanest things out there. Great add-on if you’re blasting, cruising, or just tired of feeling mentally flat.
Disclaimer:
This was smth that peaked my interest and possibly will experiment with it.
This post is for information only and not medical advice.
Everyone’s medical background and stack are different, do your own research, check for interactions, and get proper labs before starting anything new.
