Reta Too Effective?

[DeliriousNatty]

Hello everyone,

Just wanted to ask what your thoughts are regarding my bloods on 500T/30V. It appears my LDL is extremely low. I don’t take any citrus bergamot, statins or red yeast.

Current regiment at time of test:
Reta 2mg/wk
Fishoil
Coq-10
Glutathione 250mg IM Daily
Tudca, nac, yatata
Telm
Cialis

For background info, prior to this cycle and using glps, I was normally low end reference range, so pretty good.
These numbers are from a week ago and are day 4 into the Anavar portion, I think I actually took 10mg var before the test by happenstance lmao

Here’s the numbers:
Total Cholesterol: 57mg/dl
Hdl: 31
LDLc: 19mg/dl
Glucose: 80
Trig: 34

AST:48
ALT:43

If anyone has any expertise with something similar, I’d love to hear advice. Thanks

 

[DeliriousNatty]

Also at time of this test I was eating around 4000ish cals daily w/ 50grams of fat max…I have since upped that to 80grams in hopes of raising it a bit.

 

[Adamfulton]

lol I’ve never seen an LDL that low … wtf lol

 

[DeliriousNatty]

lol I’ve never seen an LDL that low … wtf lol

I have blood work about 3 weeks prior to that test as well before the Anavar was added and was hdl: 52 and ldl:32.

Idk shit either

 

[BALLISTIC]

Several mechanisms shown in early human trials translational data...
↓ Hepatic VLDL production
↑ LDL receptor expression
↑ hepatic fatty acid oxidation
↓ de novo lipogenesis
↑ bile acid turnover

In phase 2 obesity/metabolic trials, retatrutide produced...
Marked reductions in total cholesterol
Significant LDLC lowering independent of statins. Triglycerides often crashing into the 30s to 40s.

That last point is key...
When TGs are that low, LDL will often “collapse” numerically, because LDLC is downstream of VLDL output.

You didn’t just run retatrutide in isolation, you stacked several LDL lowering items, without realizing how additive they are.

Your regimen hits LDL from multiple angles. Retatrutide (primary driver), Telmisartan, Fish oil, Cialis, Glutathione.

LDL as low as 10 to 20 mg/dL has not shown harm in the short to medium term.
Neurologic or hormonal issues tend to appear only with chronic fat malabsorption or severe caloric deprivation.

 

[DeliriousNatty]

Several mechanisms shown in early human trials translational data...
↓ Hepatic VLDL production
↑ LDL receptor expression
↑ hepatic fatty acid oxidation
↓ de novo lipogenesis
↑ bile acid turnover

In phase 2 obesity/metabolic trials, retatrutide produced...
Marked reductions in total cholesterol
Significant LDLC lowering independent of statins. Triglycerides often crashing into the 30s to 40s.

That last point is key...
When TGs are that low, LDL will often “collapse” numerically, because LDLC is downstream of VLDL output.

You didn’t just run retatrutide in isolation, you stacked several LDL lowering items, without realizing how additive they are.

Your regimen hits LDL from multiple angles. Retatrutide (primary driver), Telmisartan, Fish oil, Cialis, Glutathione.

LDL as low as 10 to 20 mg/dL has not shown harm in the short to medium term.
Neurologic or hormonal issues tend to appear only with chronic fat malabsorption or severe caloric deprivation.

Thankyou for this thorough reply. I can see how the multiple vectors contribute to a much lower ldl…but I was under the impression that ldl went up, even just marginally with orals and aas.

Am I off base here?

You def make me feel slightly better knowing that it’s not the worse thing ever to have it that low for a short time.

The worst side I’ve noticed ( that I’ve attributed to low lipids) is probably joint related. Had some bad tennis elbow after pushing shoulder press hard for a few weeks in a block.

Thanks again for all your help man! Anything immediate you’d suggest to raise it efficiently aside from eating high fats?

 

[just some dude]

it’s much more likely you have better functioning ldl receptors (repatha is based off those genetics) than to say you’re a hyper responder to a glp hahah

 

[just some dude]

congrats tho man, gifted heart health genetics.

 

[DeliriousNatty]

Hmmm, I’ll look into this. Thankyou for the tip. I’d be more happy if they weren’t so low hhahah

 

[BALLISTIC]

Thankyou for this thorough reply. I can see how the multiple vectors contribute to a much lower ldl…but I was under the impression that ldl went up, even just marginally with orals and aas.

Am I off base here?

You def make me feel slightly better knowing that it’s not the worse thing ever to have it that low for a short time.

The worst side I’ve noticed ( that I’ve attributed to low lipids) is probably joint related. Had some bad tennis elbow after pushing shoulder press hard for a few weeks in a block.

Thanks again for all your help man! Anything immediate you’d suggest to raise it efficiently aside from eating high fats?

Are you suffering any side effects currently? If you aren't I would not worry, again in the short term. Dependant how long you intend to run Reta.

 

[DeliriousNatty]

Well not really anything out of ordinary, since I’m in a blast rn, I kind of attributed everything to estrogen lmao.

I’ve gotten bloods done recently now and it was high in the beginning, but good 2nd.

Soooo TLDR, small joint issues and dry ish skin but that’s about all. Some upping the fats things feel a lil better

 

[BALLISTIC]

Well not really anything out of ordinary, since I’m in a blast rn, I kind of attributed everything to estrogen lmao.

I’ve gotten bloods done recently now and it was high in the beginning, but good 2nd.

Soooo TLDR, small joint issues and dry ish skin but that’s about all. Some upping the fats things feel a lil better

What's your androgen load look like? And E2 in comparison? Reason I ask is I'm trying to compile some data on estrogen levels in relation to androgen load.

Joints and dry skin are inheritantly low E in reference to androgen burden. Not purely in each case but more often than not. Essentially stating that E2 numbers mean shit outside what the androgen load looks like. Often low and high E mimic each other, then we rely on a lab number to suggest what we do, and this is inheritantly wrong bro science, and irrelevant depending what compounds are being run, that is obviously absent negative sides, which again will be individual.

Thread 'Aromatase Inhibitors Fix the Number but Break the System, open discussion.' Aromatase Inhibitors Fix the Number but Break the System, open discussion.

 

[DeliriousNatty]

At time of test it was 72mg test daily and I believe 1 week into 30mg Anavar(20mg pre-w, 10 seperate).

Total T: 4220
Free T: 1230
E2: 140

The joint issues were occurring around the time I started using ai, but I didn’t have any estrogenic symptoms aside from slightly high bp.

Ai used since: .25mg twice a week

I have another blood test scheduled for March 1st, so I’ll keep yal updated with what happens.

I also got a 23 and me coming in a few weeks, so I’d be interested in seeing if perhaps I have some predisposition or something cool along those lines.

Thanks again for all your help.

 

[DeliriousNatty]

Reading through this it looks blatantly obvious I had low e2 issues…I’d lean otherwise as .5mg arimidex isn’t enough at all to crash me prior to this so maybe it’s just all cumulative with the reta, lowering of e2 and other ancillaries.

Thus allowing for perfect storm at time of blood test? Idfk hhahaha