Reta phase 3 results out


I’m waiting for commentary from @Ghoul @Photon and others. They ratcheted these poor bastards up to 12 mg daily. Can’t imagine taking that much. Efficacy was above expectations but so was discontinuation rate (again, 12 mg is nuts).

Lilly has 7 more Reta trials in the works.

Surprising results given how many use it because they don’t feel strong appetite suppression.

Those other trials all to find non obesity conditions that’ll qualify for insure coverage.

In other pharma news, Wegovy 7.2mg (yes. Sema up to 7.2mg) and Orforgliplon awarded National Priority Vouchers by the FDA to speed up approval of drugs important for national priorities to 2-3 months instead of years.

 

I’m waiting for commentary from @Ghoul @Photon and others. They ratcheted these poor bastards up to 12 mg daily. Can’t imagine taking that much. Efficacy was above expectations but so was discontinuation rate (again, 12 mg is nuts).

Lilly has 7 more Reta trials in the works.
where are you seeing that the dose was 12mg daily? From what I see it says once weekly. And 2% weight loss difference between 9 and 12mg over 68 weeks shows how quickly the deminishing returns hit. IMO past 8mg of reta ur just wasting ur money. If u need more appetite suppresion you should look to add sema or cagri.
 
Surprising results given how many use it because they don’t feel strong appetite suppression.

Those other trials all to find non obesity conditions that’ll qualify for insure coverage.

In other pharma news, Wegovy 7.2mg (yes. Sema up to 7.2mg) and Orforgliplon awarded National Priority Vouchers by the FDA to speed up approval of drugs important for national priorities to 2-3 months instead of years.

I feel like the "reta doesn't have strong appetite suppression" mantra is more placebo / word-of-mouth than anything else and has spread like fire on the internet but very clearly isn't evidenced based. 12mg of reta is some serious shit and the dropout rate doesn't surprise me at all. In fact it seems like a poorly designed study, because they already had data from Phase 2 showing high dropout rate and therefore no incremental weight loss in the 12mg group (since dropouts are included in the averages).

Also not surprising - EL makes no mention of proportion of lean mass loss. If you calculate the incremental weight loss from reta versus tirz in the Phase 2 studies, it is entirely lean mass on the 8mg+ doses - meaning individuals could actually have lost MORE fat on tirz. (And yes, I understand protein, strength training, etc. I'm talking about the population these medications are actually intended for).
 
Surprising results given how many use it because they don’t feel strong appetite suppression.

Those other trials all to find non obesity conditions that’ll qualify for insure coverage.

In other pharma news, Wegovy 7.2mg (yes. Sema up to 7.2mg) and Orforgliplon awarded National Priority Vouchers by the FDA to speed up approval of drugs important for national priorities to 2-3 months instead of years.

Great news
 
where are you seeing that the dose was 12mg daily? From what I see it says once weekly. And 2% weight loss difference between 9 and 12mg over 68 weeks shows how quickly the deminishing returns hit. IMO past 8mg of reta ur just wasting ur money. If u need more appetite suppresion you should look to add sema or cagri.
Typo. 12 mg weekly.
 
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