MESO-Rx
Anabolic Steroids
Reta phase 3 results out
- Thread starter RockyP
- Start date
Ghoul
Member
Surprising results given how many use it because they don’t feel strong appetite suppression.
Those other trials all to find non obesity conditions that’ll qualify for insure coverage.
In other pharma news, Wegovy 7.2mg (yes. Sema up to 7.2mg) and Orforgliplon awarded National Priority Vouchers by the FDA to speed up approval of drugs important for national priorities to 2-3 months instead of years.
FDA Awards Second Batch of National Priority Vouchers
The U.S. Food and Drug Administration today announced six additional awardees under the Commissioner’s National Priority Voucher (CNPV) pilot program.
MentEFresh
New Member
where are you seeing that the dose was 12mg daily? From what I see it says once weekly. And 2% weight loss difference between 9 and 12mg over 68 weeks shows how quickly the deminishing returns hit. IMO past 8mg of reta ur just wasting ur money. If u need more appetite suppresion you should look to add sema or cagri.
I feel like the "reta doesn't have strong appetite suppression" mantra is more placebo / word-of-mouth than anything else and has spread like fire on the internet but very clearly isn't evidenced based. 12mg of reta is some serious shit and the dropout rate doesn't surprise me at all. In fact it seems like a poorly designed study, because they already had data from Phase 2 showing high dropout rate and therefore no incremental weight loss in the 12mg group (since dropouts are included in the averages).Surprising results given how many use it because they don’t feel strong appetite suppression.
Those other trials all to find non obesity conditions that’ll qualify for insure coverage.
In other pharma news, Wegovy 7.2mg (yes. Sema up to 7.2mg) and Orforgliplon awarded National Priority Vouchers by the FDA to speed up approval of drugs important for national priorities to 2-3 months instead of years.
FDA Awards Second Batch of National Priority Vouchers
The U.S. Food and Drug Administration today announced six additional awardees under the Commissioner’s National Priority Voucher (CNPV) pilot program.www.fda.gov
Also not surprising - EL makes no mention of proportion of lean mass loss. If you calculate the incremental weight loss from reta versus tirz in the Phase 2 studies, it is entirely lean mass on the 8mg+ doses - meaning individuals could actually have lost MORE fat on tirz. (And yes, I understand protein, strength training, etc. I'm talking about the population these medications are actually intended for).
RockyP
Member
Great newsSurprising results given how many use it because they don’t feel strong appetite suppression.
Those other trials all to find non obesity conditions that’ll qualify for insure coverage.
In other pharma news, Wegovy 7.2mg (yes. Sema up to 7.2mg) and Orforgliplon awarded National Priority Vouchers by the FDA to speed up approval of drugs important for national priorities to 2-3 months instead of years.
FDA Awards Second Batch of National Priority Vouchers
The U.S. Food and Drug Administration today announced six additional awardees under the Commissioner’s National Priority Voucher (CNPV) pilot program.
RockyP
Member
Typo. 12 mg weekly. I don’t think EL really thinks there’s a linear dose response up to 12 mg. I think they are all in a pissing match to see how high they can push the dosages.
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MentEFresh
New Member
Sema has much higher binding affinity for glp1, that translate to much more fullness, being full for longer, and so forth. It absolutely is the stronger appetite suppressant. Reta is still superior for fatloss due to the insulin sensitivity (from the GIP) and mild fat burning from the glucagon tho.
RockyP
Member
Yes I think high dose Reta is not a great option for the general population who isn’t eating enough protein and not strength training. At some point with reta it seems the more you eat (especially carbs) the more weight you lose. I think the glucagon agonism is likely to lead to more LBM loss in the general population.
End of the day people should take what they tolerate and what is covered by their insurance. Personally, I prefer Reta but if Tirz was the only option that would be fine also.
Ghoul
Member
Also, Glucagon is a catabolic hormone. This can be offset with sufficient protein intake, but muscle loss is already an issue for the general GLP using public, who aren’t getting sufficient protein, Reta could make that slightly worse.
xrayphoton13
Member
This is interesting. I wonder if it's completely offset by our population's use of AAS and weightlifting and high protein or if tirzepatide is still the better choice for fat loss.
I'm also surprised like you about reta being more effective at weight loss than tirz. Maybe I just didn't take enough but I take 10mg tirzepatide and lost a massive amount of weight. I switched to up to 8mg reta for a few months and could still eat all I wanted, I even ended up in a surplus gaining weight.
I kinda want to try a new experiment and titrate up to 7.2mg semaglutide now but my old qsc 2mg semaglutide vials would make that quite difficult
just some dude
Member
yeah that’s true, in this scene people use aas and/or hgh but for the average person they don’t have the same complementary combination
(anabolic agent(s) + 1/3 glps)
(anabolic agent(s) + 1/3 glps)
RockyP
Member
More fat loss while eating a lot more than I could on tirz. It’s more conducive to bodybuilding (for me). Tirz destroyed my appetite at 7.5 mg per week. Reta I can slowly work up or down and get all the metabolic benefits with less appetite suppression.
If I were competing I would only use it in the off season or only the first half of prep. It’s hard to get / stay full (muscles not appetite). I think most open BBers will settle on using it at lower doses in the offseason to keep fat loss minimal and run more GH. I’m sure it CAN be used precontest but it depends on the person and their experience with it. I just think that it’s goin to be much harder for these bigger guys to peak right on GLP-1s. I think that’s what we saw with Nick Walker this year at the O. Some of these guys are loading on 1000+ g carbs. I don’t see how you do that with slowed gastric emptying.
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RockyP
Member
I think they also mentioned the skin sensitivity as a limiting side effect.
BP_6
Member
12mg weekly as has been stated. Daily would probably be a bad thing. I am experimenting right now with a reta/tirz combo which when combining the two, would be the "max dose."
*8mg reta/5mg tirz" two separate injects at the same time once a week.
So far.
Appetite is OK before breakfast. Breakfast is rather light
Meal 2, is the heaviest. It used to be 8oz 95/5 ground beef, salmon, or chicken breast, about 150 grams of white rice, two eggs, and 1oz of fat free cheese.
Hungry before meal a bit, but meal reduced to 4oz beef, one egg, and 1 oz of cheese rice the same and that is fully satisfactory
After that, I have little desire for food for the rest of the day. However I have no issue eating lighter, easier to digest foods and I need to to keep protein and carbs up. Minimum 200 grams of protein and carbs can vary from 150-300grams but usually at the lower-mid end of that.
Next 3 meals usually "now" consist of high protein greek yogurt, dates, 30-45 gram protein shakes, karbolyn, those clear 20 gram whey protein drinks etc.
Used to have extreme cravings for very calorie dense peanut butter. Those cravings have been nuked pretty much completely. Same for nuts. Seems to have completely changed my thinking about food. I no longer "feel" I need to eat so much. Probably because I am plain just not very hungry when before I had a hell of an appetite. So it isn't just appetite, cravings have also been eliminated. So I can understand why some claim it is killed their cravings for other things like alcohol and even smoking in some cases.
Desire to workout and train remains completely unchanged. Sleep is sold overall. RHR is higher than I would like it to be. Gym performance is not effected as bad as it was in the past due to me keeping my carbs up a lot more and able to reduce fat greatly from no more PB. Weight is dropping at a steady, but not too fast of a pace. Muscle mass is fine with no more muscle loss than expected. Only sides I don't like are the although less now sunburn skin feeling, RHR increase, and if I eat a big carb meal and don't keep active after, sleepiness likely due to an enhanced insulin response. Blood glucose levels which i check regularly with a glucose meter are also better than they ever have been. Bordering on the bit too low side. Also had to lower my BP meds as my blood pressure started dropping too low and I would sometimes get dizzy if I stand up too fast.
I can say the effects and what difference I notice with this drug is right up there with the muscle mass anabolic steroids at one time added to my body and strength.
Well there is my full up to date report for those who would like some anecdotal experiences.
*8mg reta/5mg tirz" two separate injects at the same time once a week.
So far.
Appetite is OK before breakfast. Breakfast is rather light
Meal 2, is the heaviest. It used to be 8oz 95/5 ground beef, salmon, or chicken breast, about 150 grams of white rice, two eggs, and 1oz of fat free cheese.
Hungry before meal a bit, but meal reduced to 4oz beef, one egg, and 1 oz of cheese rice the same and that is fully satisfactory
After that, I have little desire for food for the rest of the day. However I have no issue eating lighter, easier to digest foods and I need to to keep protein and carbs up. Minimum 200 grams of protein and carbs can vary from 150-300grams but usually at the lower-mid end of that.
Next 3 meals usually "now" consist of high protein greek yogurt, dates, 30-45 gram protein shakes, karbolyn, those clear 20 gram whey protein drinks etc.
Used to have extreme cravings for very calorie dense peanut butter. Those cravings have been nuked pretty much completely. Same for nuts. Seems to have completely changed my thinking about food. I no longer "feel" I need to eat so much. Probably because I am plain just not very hungry when before I had a hell of an appetite. So it isn't just appetite, cravings have also been eliminated. So I can understand why some claim it is killed their cravings for other things like alcohol and even smoking in some cases.
Desire to workout and train remains completely unchanged. Sleep is sold overall. RHR is higher than I would like it to be. Gym performance is not effected as bad as it was in the past due to me keeping my carbs up a lot more and able to reduce fat greatly from no more PB. Weight is dropping at a steady, but not too fast of a pace. Muscle mass is fine with no more muscle loss than expected. Only sides I don't like are the although less now sunburn skin feeling, RHR increase, and if I eat a big carb meal and don't keep active after, sleepiness likely due to an enhanced insulin response. Blood glucose levels which i check regularly with a glucose meter are also better than they ever have been. Bordering on the bit too low side. Also had to lower my BP meds as my blood pressure started dropping too low and I would sometimes get dizzy if I stand up too fast.
I can say the effects and what difference I notice with this drug is right up there with the muscle mass anabolic steroids at one time added to my body and strength.
Well there is my full up to date report for those who would like some anecdotal experiences.
ParquetPatquet
New Member
But what does weight loss have to do with appetite surpression
. I'm only half kidding, appetite suppression doesn't mean weight loss, and vice versa. Otherwise, Sema would be king.shredded.lyfe
New Member
Absolutely moronic and just clear junkie behaviour.
Pinning 2 competing compounds, ill never understand you gymbros.
BP_6
Member
Well, dosing in reta is generally 2, 4, 6, 8, 10, 12 and tirz it is 2.5, 5, 7.5, 10, 12.5, and 15.
So basically all other things equal, 8mg reta and 5mgtirz is the 12/15 equivalent max dose. I know it isn't that simple but that is the logic. That and I have both compounds. I can always drop the dose or drop one or the other which I probably will do as it is unlikely I will want this low of an appetite for an extended period of time.
Don't know what to say about the junkie thing, I guess opinions vary. I can say I have never had a drink or ever touched a single rec drug in my life and that includes weed. So I guess the definition can vary, but you are obviously entitled to your opinion.
Photon
Member
I don't have much to comment lol.
I stopped following GLP news after i decided on using reta.
I'm currently taking 1/2 a vial of SSA 50mg now 1x a week.
The dropout rates do seem really high tho, 3x higher vs tirz.
However, 18.2% of patients dropped out of the retatrutide study due to gastrointestinal side effects. In comparison, 6.2% of patients given a 15-milligram dose of tirzepatide dropped out, Risinger said. The discontinuation rates correlated with a higher body mass index, or BMI, at the start of the test and included patients who dropped out after "perceived excessive weight loss."https://www.investors.com/news/technology/eli-lillys-experimental-obesity-drug-cut-weight-by-23-7/
