Reta Microdosing (<1.5mg) to improve lipids?

[Banana Joe]

I had already asked here, but it sadly didn't get any replies.

How many of you guys are taking microdoses of Reta (<1.5mg?) mainly to improve HDL/LDL?
I have seen quite a few people on YT making similar claims, but Big Paul is the first one that provided actual numbers.

Other benefits should be:
- improved insulin sensitivity (might be even a given)
- reduced visceral and liver fat via glucagon receptor signaling


I always had bad HDL/LDL (hereditary) and have started taking 0.2mg e2d of Reta just recently. So far I feel no reduction in appetite, which is critical for me, as I have become a terrible eater over the years. If I feel no ill effects, I might up the dose to 0.3mg e2d.
Haven't gotten a new blood panel as my diet is a bit terrible atm, and I need to fix that first to get any meaningful data.

 

[ChemBB]

I love a med that's good twofer, or threefer, lol.

Recent research is increasingly finding Amlodipine is associated with lower rates of all types of psychiatric / cognitive issues. Apparently many are related to calcium channel dysfunction in the frontal cortex.

Amlodipine works because it enters the brain (in tiny amounts). Now it's being considered as an alternate ADHD treatment.

As it turns out, Cilnidipine passes the blood brain barrier twice as effectively as Amlodipine.

Unfortunately Ciln hasn't been included in these studies (they're all US based so only using available CCBs). But in theory it should be much better than Amlodipine for this.

A lot of folks report just feeling better on Ciln, overall well being. I attributed that to the way Ciln blocks the release of adrenaline in response to stress (without sedation) but perhaps there'd even more than that going on...

Seeing my cardio for first followup today

Should I ask for this?

Currently on Metoprolol Lorsartan Atorvastatin Ticagrelor Aspirin

Was going to ask for Nebivolol, Telmisartan, Pitavastatin

 

[Ghoul]

Seeing my cardio for first followup today

Should I ask for this?

Currently on Metoprolol Lorsartan Atorvastatin Ticagrelor Aspirin

Was going to ask for Nebivolol, Telmisartan, Pitavastatin

Do you have reduced ejection fraction or other heart issues?

 

[ChemBB]

Do you have reduced ejection fraction or other heart issues?

Not as far as recent ECG showed

 

[ChemBB]

Seeing my cardio for first followup today
Currently on Metoprolol Lorsartan Atorvastatin Ticagrelor Aspirin
Was going to ask for Nebivolol, Telmisartan, Pitavastatin

Got him to swap me to Nebivolol + Telmisartan, though low doses

 

[Ghoul]

Got him to swap me to Nebivolol + Telmisartan, though low doses

Both are much better metabolically, with lower side effects. Pitavastatin leaves most of them pretending to know what it is.

 

[ChiefLapu]

Sharing an update to my lipid changes since being on Reta for ~6 months now. I started in June 2025 and got initial lab work after 3 weeks. Looking back I wish I had gotten labs before starting but ah well.

It seems to have had a profoundly positive impact on my LDL, down 63% since starting. My triglycerides increased and HDL decreased, and while not ideal are still within acceptable ranges.

I did not have a large amount of weight to lose. Here are my stats through this journey. For reference I am a 6’0 male, around 13% bf currently.

Starting weight: 200lb

Lowest weight: 177lb

Current weight: 185lb

My dosage was between 2 - 3mg per week for most of this period.

I am curious how much of this improvement is due to the actual drug itself as opposed to the weight loss given it was modest. My diet has been very clean throughout this period and while it wasn’t bad before starting, Reta has made it remarkably easier to adhere to a clean diet.

 

[Avies48]

Sharing an update to my lipid changes since being on Reta for ~6 months now. I started in June 2025 and got initial lab work after 3 weeks. Looking back I wish I had gotten labs before starting but ah well.

It seems to have had a profoundly positive impact on my LDL, down 63% since starting. My triglycerides increased and HDL decreased, and while not ideal are still within acceptable ranges.

I did not have a large amount of weight to lose. Here are my stats through this journey. For reference I am a 6’0 male, around 13% bf currently.

Starting weight: 200lb

Lowest weight: 177lb

Current weight: 185lb

My dosage was between 2 - 3mg per week for most of this period.

I am curious how much of this improvement is due to the actual drug itself as opposed to the weight loss given it was modest. My diet has been very clean throughout this period and while it wasn’t bad before starting, Reta has made it remarkably easier to adhere to a clean diet.

Its the reta… i can drop weight but weight loss doesnt effect my liver wnd how it works tbh… weird ur triglycerides went up… id throw in some good doc scripted fish oils to lower that

Ima hit up reta as well… but im not sure i can stand the 2-3 mlg per week tbh… i cant stand being nauseous …