Many times people can't take reta side effects. I know my reason for adding mazdutide to tirz: I was using tirz plus reta. It was working well; I would never have lost as much as I did on tirz alone. My liver enzyme levels shot up quite high. At one point, my ALT was 10 times the upper limit of normal. I had to visit a hepatologist. I told him the truth: I told him about tirz and reta. He suggested that the likely cause is the atorvastatin (Lipitor) that I'm taking but also asked that I stop taking retatrutide too. He said to keep taking the tirz. He told me if the numbers didn't go down, he'd recommend a liver biopsy. That's an outpatient procedure but it would require that I take a week or two off work. In other words, it's a somewhat involved procedure. I stopped taking the reta and the statin. Then, after my numbers fell, I started taking the reta again. My numbers went up a little bit. (I have since learn that a slight increase didn't necessarily mean much.) I decided I wasn't willing to risk continuing the reta. As a result, I stopped. If my liver enzyme numbers get perfectly normal, I'll probably add reta unless I decide I prefer reta. I started maz yesterday. It's way too early for me to say whether it's a good or bad thing. I'm about eight pounds heavier than when I initially had t stop reta. I'd like to lose that eight pounds. Then I'd be at my goal, 160 pounds, before I started on weight loss drugs. But I have a new goal: 150 pounds. I'm a male and 5'7." Despite being on this forum, I'm probably about as muscular as an average American man of my age, the mid-fifties. I have a hard time seeing a reason to get below 150 pounds.
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QingLiShangMao
- Thread starter Stealth500
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I'm new to the Ghetto/Reta Telegram group, but I haven't heard people talking that way. If someone actually wants to say that mazdutide might be better than reta, that's a possibility based upon two small, short-term studies of reta, which saw dramatic weight loss in short time periods of being on a high dose. Bhattachar, et al. (pre-publication, 2025-08-20). Mazdutide reduces body weight in adults with overweight or obesity - A high-dose Phase 1 trial. Diabetes Obesity & Metabolism, doi.org/10.1111/dom.70040, Microsoft OneDrive; Ji, et al. (2022). Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity - a randomised, placebo-controlled, multiple-ascending-dose phase 1b trial. EClinicalMedicine 54, 101691, https://www.sciencedirect.com/science/article/pii/S2589537022004217. However, even Eli Lilly must be suspicious of these results: Eli Lilly has NOT announced an intention to conduct a stage three trial of mazdutide. (The stage three trials that got it approved in China were conducted by Innovent, which is licensed by Eli Lilly to sell mazdutide there.)
You should understand what you are injecting before assuming wrong shit lol
Reta skyrocketed your liver enzymes due to fatty liver that's what you have mostly what was your GGT level? I bet not elevated much. Only alt ast was high wasn't it?
GGT was fine as was ALP. I'm a little skeptical that ALT would rise to 10 times the normal level simply due to defatting the liver, particularly since those levels were not seen in the trials and I met the criteria for being kicked out of the reta study.
Here is part of the research protocol for
Jastreboff, A. M., Kaplan, L. M., Frías, J. P., Wu, Q., Du, Y., Gurbuz, S., Coskun, T., Haupt, A., Milicevic, Z., & Hartman, M. L. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New England Journal of Medicine, 389(6), 514–526.
I met all three criteria. While those criteria did not REQUIRE discontinuation and only required consideration of discontinuation, those patients would have the benefit of careful medical monitoring.
You're basically asking me to ignore the advice of my hepatologist and the views of those who designed the reta research trial. And I'm supposed to this based upon the advice of some dude off the internet? I grant you that many of the folks here at Meso know a great deal. Still I'm unwilling to keep pushing against medical advice at this point particularly when that also means going against the practices of the researchers who work with the rapid liver-defatting GLP-1 drugs. I look forward to my liver enzyme levels returning to normal. At that point, I'd likely try reta again.
In one of the mazdutide trials, ALT rising to three times the upper limit of normal was sufficient to warrant to not injecting a patient on one occasion. Both maz and reta rapidly defat the liver.
The document that appears below was part of peer review that preceded publication of Bhattachar, et al. (pre-publication, 2025-08-20). Mazdutide reduces body weight in adults with overweight or obesity - A high-dose Phase 1 trial. Diabetes Obesity & Metabolism, doi.org/10.1111/dom.70040, Microsoft OneDrive. It shows that even with mazdutide, a drug that rapidly defats the liver, an ALT reading of three times the upper limit of normal was concerning.
Both my hepatologist and I believe that the likely cause of the elevated liver enzymes is the Lipitor (atorvastatin) that I'm taking. However, we're both not willing to risk things further at this point.
He advised me that if my liver enzymes remained elevated, I would have to undergo a liver biopsy.
No dude you misunderstood me lol as you haven't posted any numbers that what it looked like. Plus Lipitor can do that too. So the best would be reassess to situation when you have quitted the lipitor and your liver enzymes are back to normal then add reta and slowly monitor
After I responded, I did realize I hadn't posted numbers. (I had posted numbers elsewhere on reta.) As a result, the whole time I was responding to you, I thought you were being unreasonable when you were not. I agree with you that it's probably the Lipitor. And I agree that once my liver enzyme levels are fine, then it's time to add reta again. I believe that without the statin, I'll be fine. There should not be a rapid defatting of the liver because three months ago, when I had a Fibroscan, I did not have a fatty liver. (The hepatologist said I may have had a fatty liver before.) I'll probably end up on pitavastatin. I'll have to separate adding another statin back and adding reta with enough time and blood tests so that I know what's caused what.
