Post up your Natty IGF-1 Level

[AlexDavis43]

View attachment 322944

Good study. Damn that's high (20 mg in study one and 6 mg in study 2) if it was daily dosing, but it was one time.

How has 2 mg/d worked out for body composition?

 

[zpped]

i am wondering if i have some sort of adrenal gland problem, causing my lower igf1 score,

Whats your E2? If you have room, try raising it a little and keep gh the same. Dr. Todd Lee claims there is a cap on gh->ifg conversion depending on e2 level.

 

[Middus]

Good study. Damn that's high (20 mg in study one and 6 mg in study 2) if it was daily dosing, but it was one time.

How has 2 mg/d worked out for body composition?

I can't judge based on the CJC alone unfortunately. I started reta 2 weeks before the CJC and i can see more visceral fat loss. My initial Tesa run also had positive effect on visceral fat loss (anecdotally, compared to when i lost weight from a sleeve gastrectomy a decade ago).
Not continuing with CJC (mod GRf) though. It messes with the pituitary glands of mice, so i don't know what that high a dose is doing to mine. It also messes with the pocket/finances as GH is cheaper. I was just curious, and so used myself as a guineapig for a brief period.

 

[AlexDavis43]

I can't judge based on the CJC alone unfortunately. I started reta 2 weeks before the CJC and i can see more visceral fat loss. My initial Tesa run also had positive effect on visceral fat loss (anecdotally, compared to when i lost weight from a sleeve gastrectomy a decade ago).
Not continuing with CJC (mod GRf) though. It messes with the pituitary glands of mice, so i don't know what that high a dose is doing to mine. It also messes with the pocket/finances as GH is cheaper. I was just curious, and so used myself as a guineapig for a brief period.

Would you like a pituitary or thyroid tumor with that?

jk I used both and am hoping neither. Still using GH (a lot).

 

[serkan]

I have the same question: I'm 50 years old and my Ig value is 217. See picture. I would also like to inject 2 IU of HGH. Would it increase or decrease my value? When you inject Ig, your own HGH production stops.

 

[Ateam2023]

I have the same question: I'm 50 years old and my Ig value is 217. See picture. I would also like to inject 2 IU of HGH. Would it increase or decrease my value? When you inject Ig, your own HGH production stops.

Thats a great question , but you're going to just have to give it go, everyone responds differently to hgh and no set dose will/willnot raise your igf1 per say, hgh appears to be very individual depending on a multitude of factors,,

 

[AlexDavis43]

Thats a great question , but you're going to just have to give it go, everyone responds differently to hgh and no set dose will/willnot raise your igf1 per say, hgh appears to be very individual depending on a multitude of factors,,

The average IGF1 levels of Meso members on 2 IU hGH/d is 300 but the range is 200-450.

 

[The Answ3r]

The average IGF1 levels of Meso members on 2 IU hGH/d is 300 but the range is 200-450.

Since you seem well-versed in this, do you have any info on how long it’s safe to keep IGF-1 levels in the 400+ range? Would it be smarter to drop down into the typical range and stay around 250–300 instead? I ran it by ChatGPT and it said 450 is likely fine for up to 6 months, but curious what your take is.

 

[AlexDavis43]

Since you seem well-versed in this, do you have any info on how long it’s safe to keep IGF-1 levels in the 400+ range? Would it be smarter to drop down into the typical range and stay around 250–300 instead? I ran it by ChatGPT and it said 450 is likely fine for up to 6 months, but curious what your take is.

No idea mate. I plan on staying on gear (including hGH) indefinitely.

I live healthier than pretty much anyone else I know otherwise.

If someone told me definitively gear would knock a couple years off my life, I'd just hope they're the shitty years toward the end.

 

[bigforyouben]

Update: After 2 months no HGH and no GH secretagogues (and no alcohol) IGF-1 was 109. Three weeks later, after 2mg Tesamorelin ED, IGF-1 was 223.

I'm going to stay on the Tesamorelin for a couple more months until the supply runs out, then I'll try HGH again.

 

[kaizoku]

Exactly. 1.5 as soon as I wake up, 1.5 right before bed.

Also, took 2iu last night, 1.3iu this morning and will leave the PM dose at 2iu and titrate the AM dose up to 2iu until I run out of greys or have to back down because of CTS sides.

Quoting my own post here for an update.

I worked up to 3.5iu, tingly hands and arms waking up me constantly every night.

Went on a work trip for 5 days and had to toss the vial I brought with me because it froze.

So no HGH for 5 days, came home and hands were still falling asleep so I started back up on 2.5iu to try to reduce sides.

I have to head back on the road and needed blood work for my TRT so I pulled labs last Thursday after being off for 5 days and then back on 2.5iu for 6.

IGF-1 = 177…FML

 

[The Answ3r]

Quick update on HGH: I recently bumped the dose up to 4iu and switched from Opti to Lobster. Planning to run new bloodwork in about 5–6 weeks, aiming to see IGF-1 somewhere around 500+.

I also changed my injection timing from doing it right before bed to doing it first thing in the morning and honestly, it made a big difference. Sleep has improved, and I’m not waking up with that water retention like I used to.

If anyone’s dealing with similar issues, switching injection timing might be worth a try.

 

[Superchicken]

252ng/ml, 42yo woman. On hrt/trt to physiological levels, no prior AAS use.

I’ve always had pretty decent body comp and adding in T was enough of a boost to make noticeable gains. Was considering adding in hgh for skin/sleep benefits, but holding off for now since I’m making some changes to my hrt - will recheck later. A cursory google search shows optimal hrt can help boost igf-1 signaling.

 

[Jin23]

252ng/ml, 42yo woman. On hrt/trt to physiological levels, no prior AAS use.

I’ve always had pretty decent body comp and adding in T was enough of a boost to make noticeable gains. Was considering adding in hgh for skin/sleep benefits, but holding off for now since I’m making some changes to my hrt - will recheck later. A cursory google search shows optimal hrt can help boost igf-1 signaling.

Your levels are decent for somebody in their twenties, you don't need exogenous GH. Most (normal, non hrt clinic docs) would even discourage such high GH dosages, normal GH hrt is around 1.5 iu's ...

 

[Superchicken]

Your levels are decent for somebody in their twenties, you don't need exogenous GH. Most (normal, non hrt clinic docs) would even discourage such high GH dosages, normal GH hrt is around 1.5 iu's ...

Twenties where? I’m 42, close to 99% for my age/sex and 75% for 20s. I’m not using hgh right now and haven’t.

 

[Jin23]

Twenties where? I’m 42, close to 99% for my age/sex and 75% for 20s. I’m not using hgh right now and haven’t.

I don't think you've understood what I wrote ...

I said; your levels are that of a twenties something kid, meaning, your levels are surprisingly high for your age of 42. Ie. you do not need GH hrt at all (not for sleep and not for skin or anything) - as you were implying that you might consider going the GH hrt route, but in your case that would hardly be HRT, it would be PED use.

 

[Superchicken]

I don't think you've understood what I wrote ...

I said; your levels are that of a twenties something kid, meaning, your levels are surprisingly high for your age of 42. Ie. you do not need GH hrt at all (not for sleep and not for skin or anything) - as you were implying that you might consider going the GH hrt route, but in your case that would hardly be HRT, it would be PED use.

Yeah I’m a dumbass and misread what you wrote. I got it

 

[Proud Pangolin]

I can't judge based on the CJC alone unfortunately. I started reta 2 weeks before the CJC and i can see more visceral fat loss. My initial Tesa run also had positive effect on visceral fat loss (anecdotally, compared to when i lost weight from a sleeve gastrectomy a decade ago).
Not continuing with CJC (mod GRf) though. It messes with the pituitary glands of mice, so i don't know what that high a dose is doing to mine. It also messes with the pocket/finances as GH is cheaper. I was just curious, and so used myself as a guineapig for a brief period.

Can you give me the link of the mouse study? Cand find anything

 

[Middus]

Can you give me the link of the mouse study? Cand find anything

DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas - PMC

Drivers of sporadic benign pituitary adenoma growth are largely unknown. Whole-exome sequencing of 159 prospectively resected pituitary adenomas showed that somatic copy number alteration (SCNA) rather than mutation is a hallmark of ...

pmc.ncbi.nlm.nih.gov

FYI, It's nothing alarmist. CJC over administration showed potential for DNA damage which is counteracted with meds used to treat GH over secretion.
I mentioned the study cos I was giving myself mega doses of CJC (2mg/day)

 

[Proud Pangolin]

DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas - PMC

Drivers of sporadic benign pituitary adenoma growth are largely unknown. Whole-exome sequencing of 159 prospectively resected pituitary adenomas showed that somatic copy number alteration (SCNA) rather than mutation is a hallmark of ...

pmc.ncbi.nlm.nih.gov

FYI, It's nothing alarmist. CJC over administration showed potential for DNA damage which is counteracted with meds used to treat GH over secretion.
I mentioned the study cos I was giving myself mega doses of CJC (2mg/day)

Thanks, i was getting concerned