Dial It In
Member
That’s my experience also. I pin before bed and I’m wide awake at 2-3 am.
MESO-Rx
Anabolic Steroids
HGH 40 +
- Thread starter Mrhairyman
- Start date
benfrankparkway
Member
same for me when I used it. I would pin at 9pm up at 2-3am couldnt sleep. I switched to morning fasted at 430am, cardio by 9am I felt like I wanted to go into sleep coma
Dial It In
Member
How fasted is everyone? Hours before or after? That’s always been my hang up. Want to get the most benefits from it
benfrankparkway
Member
when I tried at night I would inject at 9pm, at least a minimum of 1 hour 30 minutes since I ate. When I switched to the morning, I would inject at 430am So i was fasted at this point for 8 hours, I wouldn't eat until 730am
Dial It In
Member
Okay. That’s how I was doing the evening and the day. I workout at 430 before work so 8 hours fasting isn’t an option. Guess I’ll roll with the hour and a half unless someone has a better take or process. Appreciate the feedback.
sionnach
Banned
I typically only eat once a day (I'm not ghey omad or anything, it's just what my schedule usually allows) so if I'm going to do something specifically "fasted state", it's 12+ hours. But if you're on a GLP or anything slowing down gut motility, that's really the only way to guarantee you're not still in the middle of digestion/absorption anyway. You gotta really push to achieve true "fasted state" on GLPs.
There's a great thread posted on GH timing that is a great, long read. Im the same way, that pinning before bed i can sleep a max of 6 hours.
It takes GH 2 hours to spike in your system after injection. It also takes glucose about 2 hours to return to baseline after a meal. You can pin shortly after a meal and still burn a lot of fat.
The easy protocol that works well for me is to take GH an hour after last meal. This is also about 2 hours before bed. This avoids insulin resistance, doesn't kill my sleep, and burns a ton of fat.
Dial It In
Member
Appreciate that brother. I’ll give that a go and I’ll go find that thread as well.
the~club~bro
New Member
Any guys here have advice for dose titration?
I recently started GH and jumped in at 3 IU before bed. After 6 or 7 days I started to notice feeling achy/sore in the joints while I was trail running. Its unmistakeable. Its like you´re OLD, over trained and need to rest a day. Ever since I started running 250mg of Test per week, Ive not had to rest, PERIOD. So I know something is off and I suspect its the GH.
Ive pulled the GH entirely and will forego the injection until the achy feelings disappear, then I intend to reintroduce the GH but at a lower dose.
What do you guys think, if 3IU is giving me issues, where should I start? Im thinking 1.5 and give it 7 days as that is when the symptons began to reveal themselves at 3IU. If after 7 days its OK, Ill bump up another 0.5 IU after another 7 days and proceed in this fashion.
Im unclear on these GH side effects and whether they are expected to be permanent or transitory. I frankly don´t want to run GH if it makes me feel like this, but if these effects are transitory and can be mitigated by gradual dose escalation I can live with it.
Thoughts?
I recently started GH and jumped in at 3 IU before bed. After 6 or 7 days I started to notice feeling achy/sore in the joints while I was trail running. Its unmistakeable. Its like you´re OLD, over trained and need to rest a day. Ever since I started running 250mg of Test per week, Ive not had to rest, PERIOD. So I know something is off and I suspect its the GH.
Ive pulled the GH entirely and will forego the injection until the achy feelings disappear, then I intend to reintroduce the GH but at a lower dose.
What do you guys think, if 3IU is giving me issues, where should I start? Im thinking 1.5 and give it 7 days as that is when the symptons began to reveal themselves at 3IU. If after 7 days its OK, Ill bump up another 0.5 IU after another 7 days and proceed in this fashion.
Im unclear on these GH side effects and whether they are expected to be permanent or transitory. I frankly don´t want to run GH if it makes me feel like this, but if these effects are transitory and can be mitigated by gradual dose escalation I can live with it.
Thoughts?
Dial It In
Member
Think we need a bit more info. How long had you been on the 3iu?
the~club~bro
New Member
6 to 7 days thereabouts
Dial It In
Member
Yeah not long enough on GH. A week is going to tell you much of a story. You on anything else? When’s the last time you had bloods done?
the~club~bro
New Member
The only compound in play is 250mg Test E per week. I did have a very simple blood panel conducted at the beginning of August. I've been running the 250mg Test since May. Everything up until now has been perfect, anecdotally and feelings wise. The onset of this ache/soreness/stiffness is immediately after the introduction of the GH. There are no other variables at play. Recent additions are dutasteride and daily boron, but these precede the soreness/stiffness by a month or more, so Im ruling those out. What do you think, maybe not GH itself but perhaps other things in the peptide?
Dial It In
Member
Lots of smarter guys than me on here with way more experience on GH. I just haven’t had the experience with those types of sides on 3iu, especially after a week. It’s not to say that your body didn’t respond and perhaps the water retention started and it’s putting some stress on your joints as your body adjust to the metabolic change. In some mild aches and pain aren’t uncommon. You can always drop down to 2iu and see what happens. As with any new compound that’s introduced there is an adjustment period. GH in particular isn’t some voodoo magic and known results and how we feel can take weeks and months to really know. This could very well be your body responding and adjusting. Try managing your retention and titrate up. If you don’t plan on getting on stage abs this is purely therapeutic you won’t need to run high levels of GH, save yourself some money that way. Concerning the peptide who knows. Is it pharma, UG etc… If your source doesn’t have testing data you might not even have GH. It’s right there with Primo as one of the most bunk product you can get from shady UG vendors. Before hopping on GH did you get your fasted insulin levels? Did you get a DEXA scan? It may seem trivial or a why should I but again we all respond different to compounds and knowing a complete baseline is imperative to our health. 99 percent of the guys here are very experienced and they will probably tell you the same thing concerning what’s happening internally and recommend to continue to monitor. Someone could tell me I’m very off base but it’s my take and just trying to help with your harm reduction.
benfrankparkway
Member
My experience was the same and I was on for a year and half. I felt really old, I acted like I was really old, my wife would call me old. I quit about 2 months after I felt like a younger man, not groggy all day wanting to sleep, no more stiff joints (ankles, knees, back)
For how much GH is touted I wish I would of had they same experience and I am just jealous, especially those who get up to 6iu and above with no problem
Dial It In
Member
Yeah for sure. Everyone definitely responds different. I’ve never pushed it to know but never had those sides on the lower end. Thought I had a shot at a pro card maybe I would. But I get what I need from the low end of the spectrum. My issue has always been being so indecisive on my timing to make the most of it. But these guys here have helped me right that ship.
Ghoul
Member
There's no need to reinvent the wheel every time these symptoms come up.
They're normal and expected, even in medical rHGH treatment.
GH causes general water retention.
IGF causes localized water retention in connective tissue. leading to nerve compression and joint discomfort.
In most cases the body equalizes water distribution within a few weeks and these side effects lessen significantly or go away completely.
If they're intolerable lower the dose for a couple of weeks, then titrate up .5-1iu, and when its tolerable titrate up again if you want.
The only things you can try to lessen these edema sides besides the above, is ensure you stay well hydrated (counterintuitive, but this allows the body to flush sodium), reduce salt intake, or if they're not going away and you want to maintain the same dose, a gentle diuretic med will help.
They're normal and expected, even in medical rHGH treatment.
GH causes general water retention.
IGF causes localized water retention in connective tissue. leading to nerve compression and joint discomfort.
In most cases the body equalizes water distribution within a few weeks and these side effects lessen significantly or go away completely.
If they're intolerable lower the dose for a couple of weeks, then titrate up .5-1iu, and when its tolerable titrate up again if you want.
The only things you can try to lessen these edema sides besides the above, is ensure you stay well hydrated (counterintuitive, but this allows the body to flush sodium), reduce salt intake, or if they're not going away and you want to maintain the same dose, a gentle diuretic med will help.
CarvinDC125
Member
It’s made a world of difference for me. I didn’t get a pre blood work done but I should have because most folks don’t get the results I got from what I understand but anyway I’m 41 now. In March of 2024 I started Tirzepatide. By February of 2025 I had lost 100 pounds but still had the biggest beer gut. Was nice everywhere but the gut.
Pic on the left is after one year on Tirzepatide and day one of HGH taken February 2025. I started at 1iu and slowly titrated up. To my current dose of 3.5ius nightly. I dropped tirzepatide 1 week after the pic on the left was taken. Now I’m only taking HGH. Planning to start TRT February of 2026. The pic on the right is what I look like now. Having been on HGH since February it has melted that beer gut. I’ve only lost 10 pounds between the two pics amazingly.
After seeing this effect my Doctor is telling me I may have actually medically needed HGH. There’s more to this crazy story but I’m rambling so here’s the pic…I can’t wait to see what 300mg of test prop a week on top of the GH is going to do next year!
Pic on the left is after one year on Tirzepatide and day one of HGH taken February 2025. I started at 1iu and slowly titrated up. To my current dose of 3.5ius nightly. I dropped tirzepatide 1 week after the pic on the left was taken. Now I’m only taking HGH. Planning to start TRT February of 2026. The pic on the right is what I look like now. Having been on HGH since February it has melted that beer gut. I’ve only lost 10 pounds between the two pics amazingly.
After seeing this effect my Doctor is telling me I may have actually medically needed HGH. There’s more to this crazy story but I’m rambling so here’s the pic…I can’t wait to see what 300mg of test prop a week on top of the GH is going to do next year!
Attachments
First time using HGH with cutting cycle(test, tren, masteron), 5ius split in two dosages. Got about 12punds of water retention in a week but no other side effects. Feeling great, sleep is better and so on. Only bad thing is the image in the mirror, quite big difference with muscle definition because of the water but fat is still burning 
Biglittlejoe
New Member
How is your fasting glucose and HbA1C?
