Has somebody tried Increlex?

[Ateam2023]

It was actually on his yt channel ,
View: https://youtube.com/watch?v=6kKAita9Ce8&si=6f_vfa5vsimp7mMw

"True Bodybuilding" i think its called

I'm not very good at "links" so i hope this worked

 

[AlexDavis43]

Sorry to ask this so bluntly but do you have any sources for this statement? Because everywhere i read LR3 has a halflife of 20-30h.

Also i want to emphasis again that im not interested in general sytemic anabolism through igf-1 but in local growth. Take me for example: my biceps is my weakspot. Everyone has one and believe me if i tell you i tried everything: high reps, low reps, high weight, low weight, HIT, Volumentraining, much rest, less rest.... and while i made progress it still remains a weakspot.

And as long as you arent a genetic monster everyone probably knows what im talking about. So thats why im interested in: can we force local growth???

PEG MGF is suppose to achieve it according to experineces but again im concerned with tge systemic effect and especially effects on the heart with PEG MGF. Increlex on the other hand is approved and also the actual igf-2 variant that is responsible for cell proliferation.

So yes i agree, for general systemic anabolism go with GH, but thats not my interest here

LR3 does NOT have a long half life. It has reduced binding to IGFBPs and actually has a really short half-life. It would be preferred for site enhancement, but probably still a waste of money.

Also, the half-life of endogenous IGF-1 is irrelevant because of IGFBPs.

GH is so cheap, it is by far the most effective way to increase IGF-1. The only use case for increlex would be if you can't figure out how to tolerate GH side effects/ insulin sensitivity, or during off periods to sensitize GHR.

This is only my opinion from experience:

I don't think the half-life or dose timing is relevant for the effects of IGF1-LR3

After a few days of consistent use, I feel it nearly all day and not just in the working muscle groups

Source: muh feelz

*also to mention this might be dose dependent; I don't get any effects from <0.5 mg/d; 0.5-1 mg/d is the sweet spot for me

 

[frenexen]

Sorry to ask this so bluntly but do you have any sources for this statement? Because everywhere i read LR3 has a halflife of 20-30h.

Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I) and an analogue LR3IGF-I in pregnant rats - PubMed

To determine whether the changes in insulin-like growth factor-binding proteins (IGFBPs) and IGF-I levels during pregnancy in rats affect the clearance of IGFs from the circulation, we have measured pharmacokinetic parameters and the tissue distribution of radiolabelled IGF-I and LR3IGF-I, a...

pubmed.ncbi.nlm.nih.gov

Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection - PubMed

The relative potency of IGF-I and the analogue LR3IGF-I to either promote growth or reverse catabolism in rats when administered by injection rather than by continuous infusion has been examined. LR3IGF-I has very low affinity for the IGF-binding proteins in the rat and hence is cleared from the...

pubmed.ncbi.nlm.nih.gov

Additionally, the 6 hour half life with increlex also doesn't apply to you, as it's half life is estimated in individuals lacking sufficient IGFBP-3, not for healthy individuals. You can see this in their own pamphlet under 12.3

https://www.ipsen.com/websites/Ipsen_Online/wp-content/uploads/sites/9/2020/04/10140519/Increlex-Full-Prescribing-Information.pdf

To summarize, the clearance rates of IGF-1 and analogues are associated with their binding affinity to IGFBPs, which prolong their half-life. DES and LR3 are much shorter because of their reduced affinity, DES more so.

I don't think the half-life or dose timing is relevant for the effects of IGF1-LR3

After a few days of consistent use, I feel it nearly all day and not just in the working muscle groups

Well, any insulinotropic effects you feel are systemic as the peptide has entered the bloodstream at that point. Obviously you're not going to feel any potential localized growth before so.