Oh you are asking why SHBG sucks, the more SHBG you have the less free test. You are supposed to have 2-3% free test of your total….when SHBG spikes without AAS you will have 1% or so which makes it impossible to recover. Once you start falling into overtraining, you will have poor sleep, you’ll get sick a lot, you’ll have high HR and BP. Trust me I’ve been there from competitive Muay Thai and I was all natural. It was a mistake using AAS in this context I truly believe is harm reduction.
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Ah, that. I thought from the sequence of your sentences that there was something significantly bad about shbg for cardiovascular improvement. I would tend to agree that that adding a small amount of aas/peptides is easier on your body than undertaking that same amount of training volume naturally.
Btw, you should give a read of the new hypotheses around shbg. I recall reading 3 ideas (with supporting evidence) that show shbg being useful for recovery/anabolism.
Ultimately, aas use is going to lower shbg anyways and provide an external source of test so that your overtrained body isn't responsible for making it.
You got a link to the study?
zangetsu13
New Member
From my own bloods I can assure you with bjj 5x p/w, lifting 3/4x p/w my shbg was still essentially non existent. That was on several cycles. With regards shbg in Natty's their test will dip from systemic fatigue in general as the body isn't concerned about anabolism at that point.
Anyway yea systemic and CNS fatigue are a real problem that people don't manage well. It's incredibly hard to over train a muscle. Your cns on the other hand. Our sport is incredibly taxing.
Anyway yea systemic and CNS fatigue are a real problem that people don't manage well. It's incredibly hard to over train a muscle. Your cns on the other hand. Our sport is incredibly taxing.
@zangetsu13 good distinction. I was indeed referring to CNS overtraining. Did you have anything you would do to manage the CNS overload?
zangetsu13
New Member
For me it's noticing signs, I take ritalin for ADHD, if I'm on cycle my cns is fairly lit up as it is with the two. Signs for me will generally be decreased energy, strength, performance, things like brain fog, increased fatigue despite long sleeps, slow recovery, often I'll end up catching a cold or getting a cold sore.
Getting enough rest is the obvious one, taking in enough protein and water, I take a deload every 4th week. Not trying to push the weight and volume if I'm training multiple times a day in bjj. Keeping my electrolytes as balanced as I can. Listening to your body is important, push it too far it pushes back. 1 week a month with lower volume and/ or less rolls won't kill us, deload from bjj and lifting. There's only so much volume the body can take before you're beyond mrv.
How does this raise SHGB?
You’ll be training really hard burning tons of calories from rolling alone. Forget the extra cardio or weightlifting. Trying to keep up with keeping in your weight class and eating the right amount of calories is easier said than done. Most fighters severally under eat.
Calorie deficit leads to an increase in SHBG. Calorie deficit over the course of years will wreak havoc on your SHBG, did for me anyway.
Your CNS will be strained, you will stop sleeping well, also leading to higher SHBG.
You will be surging cortisol because said CNS is overloaded also leading to higher SHBG. You’re probably going to be exhausted and start to drink 300-400mg of caffeine a day just to get through the day, especially to get through the work day…also making your SHBG and cortisol higher.
It’s a big snowball effect especially if you have a life outside of training, mainly a job or school.
Cool man I hear you on everything and generally agree that over training can lead to whole host of problems some of which you listed, but high SHGB? never heard this, can you link some studies?
Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men
In men, 70% of circulating testosterone binds with high affinity to plasma sex hormone binding globulin (SHBG), which determines its bioavailability in their target cells. In recent years, a growing body of evidence has shown that circulating SHBG not ...
www.ncbi.nlm.nih.gov
Again, still only hypotheses but interesting nonetheless.
Paraphrasing, megalin on the surface of cell membranes facilitates the transport of shbg bound sex hormones across cell membranes. Once inside the cells, the lower pH of the intracellular environment causes dissociation of the sex hormone from SHBG (changes in pH denature proteins), and the hormone is now free to bind to the AR. Pretty straightforward but hasn't been proven yet per se. There does seem to be data showing that Megalin does exist on muscle cell membranes and lending credence to the idea.
Another hypothesis is that an as yet unidentified receptor exists on cell membranes that allows SHBG with bound test to antagonize the AR. This states that molecules of shbg (having multiple binding sites) will bind to a sex hormone, and another shbg binding site binds to the receptor on cell membranes. (I need more reading on this part) Then the test+SHBG activates an intracellular protein that causes the accumulation of intracellular cAMP, which subsequently activates protein kinase, and protein kinase may antagonize the AR.
Again, both are only hypotheses I need to read more on the second one...when I have time lol. Life is not allowing me much leisure reading time. But both would still seem to point to testosterone molecules being necessary for AR activation, but would not preclude some initiation of AR activation from the currently bound testosterone.
Overall, I still think the focus on SHBG is mostly pointless. Especially if one is using There are much bigger concerns trying t recover from strenuous exercise.
As in, low shbg is not the cause of poor recovery, merely a symptom of the body being overworked and responding in a manner to preserve sex hormones. The concept of shbg serving as a timing/storage mechanism during these periods seems plausible.
Respectfully, I think you're focusing on the wrong part of this dynamic. SHBG is unlikely the cause but rather an outcome of the actual deficit(s) and activities that are leading to the overtrained state.
Not sleeping enough. You're already in a deficit from a recovery perspective so the cost to your body is already being felt. Subsequently, the amount of free testosterone decreases. Didn't look very long but it seemed the handful of studies I read used that language specifically instead of "raising shbg".
Eating in an energy deficit. Again, seems like elevated shbg is an outcome and the toll of lower calories is already visited upon your body.
Training excessively. Same as above but I've not come across anything that explicitly states that "excessive" training elevates shbg.
All of this is essentially pointless consideration for androgen users though.
massgainer87
New Member
Vigouros Steve just dropped a Video in this (or mma in general), worth a watch
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