Chronic low HDL but good LDL (need advice)

[buck]

These tribes don’t have suppressed HDL from PED use. If folks are going to run gear their HDL low, LdL should be minimal. For gen pop with normal HDL I don’t think such aggressive LDL treatment is so critical

I have asked Dr's , cardiologists etc. what is the optimal cholesterol, LDL. HDL etc. levels are best for longevity. and get no answer. I don't see much in the way of studies that really show it either as that really hasn't been studied. Everything is about the heart but numerous other systems use them. and what primitive tribes do may not be best either as they really don't live a log time to show what they do leads to a very old age.
If people throw in PEDS or other drugs then good luck with health. But that is no surprise.

 

[RockyP]

I have asked Dr's , cardiologists etc. what is the optimal cholesterol, LDL. HDL etc. levels are best for longevity. and get no answer. I don't see much in the way of studies that really show it either as that really hasn't been studied. Everything is about the heart but numerous other systems use them. and what primitive tribes do may not be best either as they really don't live a log time to show what they do leads to a very old age.
If people throw in PEDS or other drugs then good luck with health. But that is no surprise.

I think if you run PEDs and let your lipids run wild you are very likely to have some serious health issues. But everyone has an opinion on this.

As I mentioned to someone else above, there are threads on this board linking fairly recent studies that said internists / cardiologists are likely unaware of. Most doctor spend their days dealing with administrative burdens and other non patient care issues. They have minimal time to keep up on literature. Might I also remind you that these are the same trusted clinicians who pushed the Covid vaccines on patients (including children), which now has been walked back significantly. I would be very cautious about interpreting their apathy and hand waving as anything other than exactly that. Just because they can’t give you an answer doesn’t mean there isn’t a reasonable amount of data suggesting other courses of action are most appropriate. And finally, statins also have anti inflammatory properties which contribute to their efficacy. As @Ghoul has stated, the newest versions are cheap, well tolerated, and effective.

I do agree they are over prescribed in general pop. But if you’re using gear you are inducing dyslipidemia and other pro inflammatory states that are really not good for heart health.

 

[Avies48]

I wouldn't go on Pita with your current LDL.
Pita is weaker at lowering LDL.
Maybe looking into adding Ezetimibe and Bempedoic acid instead.

If its weak at lowering the ldl then whats it good for??

 

[RockyP]

If its weak at lowering the ldl then whats it good for??

It’s not weak. It’s weaker than one of the strongest statins and is the only one to show potential an increasing effectiveness of HDL and in some cases raising HDL.

This is like saying anavar is a “mild”
Drug. It’s not. It’s mild compared to Tren. But then so is everything else.

 

[BamaCrazy]

If its weak at lowering the ldl then whats it good for??

Weak-er. Not really weak.

 

[RockyP]

If one were to run into a situation where 4 mg pita plus zetia didn’t correct lipids you could go with rosuva. It’s “stronger” and has larger dosage range.

 

[Avies48]

I took crestor for 1 week… 5 mlg daily… by the end of that week had a dvt… not sure any statin and i will ever coexist….

So bp acid and ezet will bt the next go to… i suppose

 

[buck]

I think if you run PEDs and let your lipids run wild you are very likely to have some serious health issues. But everyone has an opinion on this.

As I mentioned to someone else above, there are threads on this board linking fairly recent studies that said internists / cardiologists are likely unaware of. Most doctor spend their days dealing with administrative burdens and other non patient care issues. They have minimal time to keep up on literature. Might I also remind you that these are the same trusted clinicians who pushed the Covid vaccines on patients (including children), which now has been walked back significantly. I would be very cautious about interpreting their apathy and hand waving as anything other than exactly that. Just because they can’t give you an answer doesn’t mean there isn’t a reasonable amount of data suggesting other courses of action are most appropriate. And finally, statins also have anti inflammatory properties which contribute to their efficacy. As @Ghoul has stated, the newest versions are cheap, well tolerated, and effective.

I do agree they are over prescribed in general pop. But if you’re using gear you are inducing dyslipidemia and other pro inflammatory states that are really not good for heart health.

I have been questioning Dr for decades. The first Dr to fire me was over 25 years ago as he didn't like my questions. Dr.s opinions differ. Human biology is not an exact science. I don't expect Dr.'s to have all the answers. Many have an illusion that they do know everything. My primary these days runs a concierge service and has anti-aging interests and have been seeing him for going on 20 years. He knows i don't agree with him all the time.

If people want to relinquish control of decisions to a Dr then that is their choice and i don't worry about it.

Years ago i would point out to people that there were no long term studies on the covid vaccine. And they were taking their chance on it is they choose to.

Testing will tell people what direction "may" be best for them. My cholesterol levels, inflammatory markers have always been in a decent range on and off cycle. Without medication. But i do use supplements and have for 40 years.

 

[RockyP]

I have been questioning Dr for decades. The first Dr to fire me was over 25 years ago as he didn't like my questions. Dr.s opinions differ. Human biology is not an exact science. I don't expect Dr.'s to have all the answers. Many have an illusion that they do know everything. My primary these days runs a concierge service and has anti-aging interests and have been seeing him for going on 20 years. He knows i don't agree with him all the time.

If people want to relinquish control of decisions to a Dr then that is their choice and i don't worry about it.

Years ago i would point out to people that there were no long term studies on the covid vaccine. And they were taking their chance on it is they choose to.

Testing will tell people what direction "may" be best for them. My cholesterol levels, inflammatory markers have always been in a decent range on and off cycle. Without medication. But i do use supplements and have for 40 years.

Years ago my training partner did nationals as a super heavy. He was on about 2500 mg injectables and the last few weeks 2-3 orals. Plus GH. He pulled labs on that cycle. Everything was normal other than slightly low HDL and very slightly elevated AST. I’ve seen those genetic anomalies and those are the guys who last at high levels in the sport. I’m on the other end of the spectrum so I’m super neurotic about stuff especially lipids. But I totally agree. This isn’t an exact science and a good portion of people who have heart attacks are not obese and don’t have severe lipid issues. But knowing how sensitive my body is to PEDs I run low doses and am very aggressive with supportive meds. Is it Doing anything beneficial? I have no idea.

 

[buck]

Years ago my training partner did nationals as a super heavy. He was on about 2500 mg injectables and the last few weeks 2-3 orals. Plus GH. He pulled labs on that cycle. Everything was normal other than slightly low HDL and very slightly elevated AST. I’ve seen those genetic anomalies and those are the guys who last at high levels in the sport. I’m on the other end of the spectrum so I’m super neurotic about stuff especially lipids. But I totally agree. This isn’t an exact science and a good portion of people who have heart attacks are not obese and don’t have severe lipid issues. But knowing how sensitive my body is to PEDs I run low doses and am very aggressive with supportive meds. Is it Doing anything beneficial? I have no idea.

I had out of range ALT and AST fairly consistently for 30 years. Once i stopped heavy training and eating 300-350+ gr of protein a day like i did for decades those levels went to mid range. Training and digesting protein release the same enzymes that they use for those tests. I only eat 200-250 gr these days. No Dr wvr cared i was a it high. In general i find people are far more similar then not. But there is a fair range for "normal" I am not sensitive to anything my body is a tank. I go years at a time without a day sick, can eat most everything, little to no pain after surgeries, pretty much feel the same whether i am on 100mg/week or more then a gram a week. But those things can also be bad as i can miss when something is not right. There are no good studies with high PED use, heck there aren't much good ones with just TRT. 'We all end up doing what is in our own comfort zone. But most of life is that way too. I just end up laughing when someone thinks they have anything in life all figured out.