Test Results on 28mg of Clomiphene Citrate Daily for HRT

[ThatYoungGuy]

Hey guys,


Looking for some experienced input here.


I’m 25, previously ran TRT and ended up fully shut down. Came off due to fertility concerns and opted to try Clomiphene Citrate monotherapy to restart HPTA rather than go back on exogenous testosterone.


Current protocol:

• Clomiphene Citrate – 28 mg daily
• No exogenous testosterone
• Prescribed through a TRT clinic

---

Labs (chronological)​

Pre-Clomiphene Citrate / Shutdown​

07/13/25

• TT: <100 ng/dL
• LH: 0.46
• E2 (sensitive): 22.4
• SHBG: 12.7 LOW
• ALT: 46 (upper range)

07/31/25

• TT: 121 ng/dL
• LH: <0.3
• E2: <5
• SHBG: 19.4
• Hematocrit: 50.8% (high-normal)
• ALT: 58 HIGH

Clearly secondary hypogonadism.

---

Post-Clomiphene Citrate Response​

10/14/25

• TT: 707 ng/dL
• Free T: 0.15 ng/mL (2.17%)
• SHBG: 27
• E2 (sensitive): 121 pg/mL HIGH
• Albumin: 5.23

11/04/25

• TT: 960 ng/dL HIGH
• LH: 10.5 HIGH
• E2: 95 pg/mL HIGH
• SHBG: 27
• Hematocrit: 50.6% (still high-normal)
• ALT: 56 HIGH
• PSA: 0.85 (normal)

LH elevation confirms endogenous production.

---

Lipids (11/04/25)​

• Total Cholesterol: 182
• HDL: 36 LOW
• LDL: 121 HIGH
• Non-HDL: 146 HIGH
• ApoB: 106 HIGH
• Triglycerides: 133
• Chol/HDL Ratio: 5.1 HIGH

---

Subjective​

• Libido through the roof
• Mild moodiness / emotional variability
• Energy and erections solid
• No vision issues
• No gyno symptoms

---

Questions​

Clinic wants to add anastrozole 1 mg/week to address estradiol.


I’m hesitant. I’ve never been a fan of AIs and would rather tolerate higher estrogen than crash it and deal with joint, libido, or lipid issues.


Also curious about long-term strategy:

• Lower Clomiphene Citrate dose vs adding an AI?
• Is long-term Clomiphene Citrate use actually unhealthy, or is that overstated?
• Would transitioning to hCG monotherapy be a smarter long-term option for health and fertility?
• Any thoughts on lipids / hematocrit trends with CC long-term?
• Thoughts on adding in a Mild Oral that wouldn't completely shutdown my test but bring it into normal range(ex: Anavar)?