Test Results on 28mg of Clomiphene Citrate Daily for HRT

[ThatYoungGuy]

Hey guys,


Looking for some experienced input here.


I’m 25, previously ran TRT and ended up fully shut down. Came off due to fertility concerns and opted to try Clomiphene Citrate monotherapy to restart HPTA rather than go back on exogenous testosterone.


Current protocol:

• Clomiphene Citrate – 28 mg daily
• No exogenous testosterone
• Prescribed through a TRT clinic

---

Labs (chronological)​

Pre-Clomiphene Citrate / Shutdown​

07/13/25

• TT: <100 ng/dL
• LH: 0.46
• E2 (sensitive): 22.4
• SHBG: 12.7 LOW
• ALT: 46 (upper range)

07/31/25

• TT: 121 ng/dL
• LH: <0.3
• E2: <5
• SHBG: 19.4
• Hematocrit: 50.8% (high-normal)
• ALT: 58 HIGH

Clearly secondary hypogonadism.

---

Post-Clomiphene Citrate Response​

10/14/25

• TT: 707 ng/dL
• Free T: 0.15 ng/mL (2.17%)
• SHBG: 27
• E2 (sensitive): 121 pg/mL HIGH
• Albumin: 5.23

11/04/25

• TT: 960 ng/dL HIGH
• LH: 10.5 HIGH
• E2: 95 pg/mL HIGH
• SHBG: 27
• Hematocrit: 50.6% (still high-normal)
• ALT: 56 HIGH
• PSA: 0.85 (normal)

LH elevation confirms endogenous production.

---

Lipids (11/04/25)​

• Total Cholesterol: 182
• HDL: 36 LOW
• LDL: 121 HIGH
• Non-HDL: 146 HIGH
• ApoB: 106 HIGH
• Triglycerides: 133
• Chol/HDL Ratio: 5.1 HIGH

---

Subjective​

• Libido through the roof
• Mild moodiness / emotional variability
• Energy and erections solid
• No vision issues
• No gyno symptoms

---

Questions​

Clinic wants to add anastrozole 1 mg/week to address estradiol.


I’m hesitant. I’ve never been a fan of AIs and would rather tolerate higher estrogen than crash it and deal with joint, libido, or lipid issues.


Also curious about long-term strategy:

• Lower Clomiphene Citrate dose vs adding an AI?
• Is long-term Clomiphene Citrate use actually unhealthy, or is that overstated?
• Would transitioning to hCG monotherapy be a smarter long-term option for health and fertility?
• Any thoughts on lipids / hematocrit trends with CC long-term?
• Thoughts on adding in a Mild Oral that wouldn't completely shutdown my test but bring it into normal range(ex: Anavar)?

 

[deuces_00]

Im not a fan of clomid/enclomiphene. If I were you I’d switch to HCG.
As for the e2, 1 mg of adex/wk will lower e2 by something like 20%. Your e2 would still be above the reference range.
Why are you avoidant of an ai? Why opt to tolerate high e2 rather than having normal estradiol levels controlled by a drug that’s been extensively researched and is predictable in its effects?

 

[ThatYoungGuy]

Im not a fan of clomid/enclomiphene. If I were you I’d switch to HCG.
As for the e2, 1 mg of adex/wk will lower e2 by something like 20%. Your e2 would still be above the reference range.
Why are you avoidant of an ai? Why opt to tolerate high e2 rather than having normal estradiol levels controlled by a drug that’s been extensively researched and is predictable in its effects?

Appreciate the input.


I’m not philosophically anti-AI, I’m just cautious about using it as a first-line fix when the elevated E2 is clearly being driven by upstream overstimulation (high LH + high endogenous T from Clomiphene Citrate), and I’ve seen a lot of guys overshoot and crash E2 with weekly bolus dosing, then end up chasing side effects in the other direction.


Given that my libido, erections, and overall function are currently good, I’m trying to avoid treating a number before I’m treating a symptom, especially when AI use can come with its own issues (lipids, joints, mood, bone density long-term, etc.). That’s why I’m leaning more toward either lowering the Clomiphene burden or potentially switching to hCG rather than stacking on top.


That said, I’m not opposed to an AI if it’s actually warranted, I just want to use the lowest effective intervention rather than jump straight to suppression.


Curious on your take re: hCG long-term, do you feel it’s generally more stable for E2/lipids than CC in your experience?

 

[Dirthand]

Hey guys,


Looking for some experienced input here.


I’m 25, previously ran TRT and ended up fully shut down. Came off due to fertility concerns and opted to try Clomiphene Citrate monotherapy to restart HPTA rather than go back on exogenous testosterone.


Current protocol:

• Clomiphene Citrate – 28 mg daily
• No exogenous testosterone
• Prescribed through a TRT clinic

---

Labs (chronological)​

Pre-Clomiphene Citrate / Shutdown​

07/13/25

• TT: &lt;100 ng/dL
• LH: 0.46
• E2 (sensitive): 22.4
• SHBG: 12.7 LOW
• ALT: 46 (upper range)

07/31/25

• TT: 121 ng/dL
• LH: <0.3
• E2: <5
• SHBG: 19.4
• Hematocrit: 50.8% (high-normal)
• ALT: 58 HIGH

Clearly secondary hypogonadism.

---

Post-Clomiphene Citrate Response​

10/14/25

• TT: 707 ng/dL
• Free T: 0.15 ng/mL (2.17%)
• SHBG: 27
• E2 (sensitive): 121 pg/mL HIGH
• Albumin: 5.23

11/04/25

• TT: 960 ng/dL HIGH
• LH: 10.5 HIGH
• E2: 95 pg/mL HIGH
• SHBG: 27
• Hematocrit: 50.6% (still high-normal)
• ALT: 56 HIGH
• PSA: 0.85 (normal)

LH elevation confirms endogenous production.

---

Lipids (11/04/25)​

• Total Cholesterol: 182
• HDL: 36 LOW
• LDL: 121 HIGH
• Non-HDL: 146 HIGH
• ApoB: 106 HIGH
• Triglycerides: 133
• Chol/HDL Ratio: 5.1 HIGH

---

Subjective​

• Libido through the roof
• Mild moodiness / emotional variability
• Energy and erections solid
• No vision issues
• No gyno symptoms

---

Questions​

Clinic wants to add anastrozole 1 mg/week to address estradiol.


I’m hesitant. I’ve never been a fan of AIs and would rather tolerate higher estrogen than crash it and deal with joint, libido, or lipid issues.


Also curious about long-term strategy:

• Lower Clomiphene Citrate dose vs adding an AI?
• Is long-term Clomiphene Citrate use actually unhealthy, or is that overstated?
• Would transitioning to hCG monotherapy be a smarter long-term option for health and fertility?
• Any thoughts on lipids / hematocrit trends with CC long-term?
• Thoughts on adding in a Mild Oral that wouldn't completely shutdown my test but bring it into normal range(ex: Anavar)?

I am fixing to pct and from what I have gathered Enclomiphine only has the isomer that you need and not the one that causes side effects like raising e2.. also I seen a study to where Enclomiphine raises testosterone by about 18% more than clomid, but If yoh are getting from a clinic the only way you can get Enclomiphine is by compounded pharmacy. I did him up.pct247 about Enclomiphine and he said he could not get it. That was a month ago, I see someone selling a india pharma brand on a third party site asked him about it and now he seems to be able to get it for me. It cost quite a bit more than clomid tho.. thanks for sharing you pct results. My baseline test was 700 3 years ago and I've been shut down hard ever since, hopefully I can recover a little..

 

[deuces_00]

considering the longest studies on CC are like 3 years, yes.
You do what you want with your E2 but I am of a fan of keeping it closer to the range. I would also say to not be so fearful of potential AI side effects because all the sides develop when they’re overused and e2 is crushed. The bad only comes when the tool is misused, not from the tool being shit.

But again, do what you please