Aromatase Inhibitors Fix the Number but Break the System, open discussion.

[Photon]

Same hormone, very different ride though.

Injectable E2 Cypionate behaves with slow release, smooth rise and fall, longer halflife (days, not hours). It's going to give more stable blood levels.

This is something I've been wondering about, why no short esters?
From pharma, it's easy to purchase e2V and e2C amps/vials.

The follow raws are all insanely easy to get
e2base
e2cyp
e2e
e2v
e2undec

There's e2ace, seemly not popular and difficult to get, used in some non-inj pharma products.

Then there's e2b which apparently, is cheap and very easy to get.

Estradiol benzoate - Wikipedia

en.wikipedia.org

It was the first estrogen to be used in humans.
No longer popular now, but still available for pets -- which means you can still buy it, pet pharma. Seems to act pretty quick if you ask me.



Raws don't cost much either.

200mg, 55bucks, from an actual legit non-UGL lab.
At 1mg/week, that's 200 weeks worth.

https://www.sigmaaldrich.com/US/en/product/sigma/e8515

 

[BALLISTIC]

This is something I've been wondering about, why no short esters?
From pharma, it's easy to purchase e2V and e2C amps/vials.

The follow raws are all insanely easy to get
e2base
e2cyp
e2e
e2v
e2undec

There's e2ace, seemly not popular and difficult to get, used in some non-inj pharma products.

Then there's e2b which apparently, is cheap and very easy to get.

Estradiol benzoate - Wikipedia

en.wikipedia.org

It was the first estrogen to be used in humans.
No longer popular now, but still available for pets -- which means you can still buy it, pet pharma. Seems to act pretty quick if you ask me.

View attachment 376164

Raws don't cost much either.

200mg, 55bucks, from an actual legit non-UGL lab.
At 1mg/week, that's 200 weeks worth.

https://www.sigmaaldrich.com/US/en/product/sigma/e8515

It would be similar to oral in the sense that you’re trying to avoid spikes, but injections obviously give way more control than oral ever will. I remember asking you about a no-ester E option, and that convo is what made me think through some of these nuances more. Funny were kinda back to that in a way....

From what I’m understanding, daily dosing of a short ester E2 does smooth things out, similar to test prop vs cyp, so the logic itself isn’t wrong. The difference seems to be that estrogen sides are way more peak sensitive than testosterone sides. Even small, fast rises in E2 can show up as water retention, BP changes, nipple sensitivity, or mood shifts.

Daily dosing helps reduce the spike, but it still doesn’t flatten things the way a long ester does. Long esters keep estrogen boring and steady, and boring estrogen is usually the goal when you’re just trying to restore signaling, not actually feel it. Short esters can work in theory, they’re just less forgiving and easier to overshoot, kind of like how TNE can spike test levels into the stratosphere for a short window. It works, but it’s not always the smoothest.

If I understand things right and estrogen behaved like testosterone at the receptor level, daily E2 benzoate/acetate would probably be way more popular. ERs don’t behave like ARs once ERα especially is saturated additional estrogen doesn’t help it just turns into sides.

Small E2 changes feel huge in my experience. For instance in my last Eq cycle my knees went first. Absolute loss in strength due to crashed E2. Terrible crunchy and admitting ignorance it got to the point I couldn't crouch down then stand back up without using the counter for assistance. When I introduced just 1mg E2cyp, within 36 hours to split the time, I was back at 100 percent, honestly even felt significantly stronger. I eventually played with 2.5mg weekly, and that was my sweet spot, maybe I could go higher to 3 or 3.5mg, but being cautious.

It probably comes down to being easier to cross the line with short esters.