I always figured the pharma trials stuck to once-a-week purely for patient compliance. Their target demographic is mostly gen-pop who probably aren't thrilled about needles. If Lilly told them to pin multiple times a week, trial drop-out rates would probably be huge.
I'm definitely no expert on this, but from what I understand, Reta's half-life is around 6 days. Wouldn't taking the whole weekly dose at once give you a massive peak (and potentially more GI sides) followed by a trough where the hunger comes back right before your next shot?
Just thinking out loud, but since most guys here don't mind pinning anyway, it seems like splitting it into two smaller doses (like E3.5D) would keep blood serum levels way more stable and smooth out the ride. Has anyone else noticed less nausea or better appetite control doing it this way?