MESO-Rx

Anabolic Steroids

Wuhan Wansheng Biotechnology Co., Ltd. (USA, International)

Highlights Only (5)
Raww said:
If true pharmacological tolerance developed to GLP's, the drug's core effects would gradually weaken over time—even while continuing the same dose. This would mean the appetite suppression, satiety signals, and glucose regulation would fade, leading to increased hunger, higher calorie intake, and weight regain while still on the medication.


That's not what the evidence shows in long-term studies (e.g., STEP and SURMOUNT extensions, up to 2+ years).


Instead:


  • Weight decreases steadily at first.
  • Then it levels off into a plateau—no further loss, but also no regain as long as the drug is continued at a stable dose.
  • People maintain the lower weight for extended periods (often 1–2+ years in trials), with sustained appetite control and metabolic benefits.

This happens because GLP-1 agonists don't simply "force" weight loss. They act on brain and gut pathways to mimic signals that tell your body it's at a certain weight level—adjusting hunger, fullness, and energy use accordingly. The medication effectively shifts your body's defended "set point" (or settling point) downward. Once you reach a new equilibrium at that lower weight:


  • Energy intake matches the reduced energy expenditure (a smaller body burns fewer calories at rest due to normal metabolic adaptation).
  • The drug continues sending appropriate signals for that new level, preventing rebound hunger or regain.

A plateau reflects the balance—not the drug losing effectiveness. True tolerance would cause the signals to weaken, hunger to return, and weight to climb back up despite ongoing treatment. Studies confirm that doesn't occur; regain typically happens only after discontinuation.
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Yeah man, good job Chat GPT’ing there very impressed. I don’t think your understanding what we’re saying but that’s ok agree to disagree and keep titrating your dose higher to get the same effects as you did when you first started and not call that building a tolerance.
 
alexxgee_ said:
Yeah man, good job Chat GPT’ing there very impressed. I don’t think your understanding what we’re saying but that’s ok agree to disagree and keep titrating your dose higher to get the same effects as you did when you first started and not call that building a tolerance.
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No dude. I don't think you are understanding the difference between the words you are using. Yeah, I'll search up definitions in order to provide accuracy.

Tolerance means something different than not feeling the side effects.

And again - the actual losing of the weight is really secondary effect of the GLP giving your body a metabolic set point. The weight is lost until the body gets to that set point. AND IT STAYS THERE. Proving that the body did not build a tolerance to the drug.

If you want to lose weight past that set point you have to increase the dose - not because you have built tolerance, but because your dose is at it's balance.
 
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alexxgee_ said:
Yeah man, good job Chat GPT’ing there very impressed. I don’t think your understanding what we’re saying but that’s ok agree to disagree and keep titrating your dose higher to get the same effects as you did when you first started and not call that building a tolerance.
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Guess how I know you're American.

They say the majority of Americans now are functionally illiterate (they would fail 6th grade English) and it truly does show on the internet.
 
Jpxxx said:
Can't believe we're having this conversation lmaooo. Wtf
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I remain peptides/orals-only when ordering from WWB. No judgement on people who inject oils from them, but how many dozens of photos do we have to see of foreign objects floating in these vials to make someone question the cost/benefit in doing so?

If you're dirt poor and cannot live without getting jacked, you do you. I was broke once too. But if you have the option/means of getting gear from a cleaner source...I simply do not understand the rationale for pursuing the Hepius stuff.
 
Ordered from China Warehouse on 12/30 received Today in US on 1/22. Both my Tren/Mast and Test C vials came in white boxes this time instead of Hepius labels. Vial on left is B500 (Tren Mast 250mg/ml each) right is Cyp 250, no foreskin in mine guess I dodged a bullet
 

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CtotheP said:
They find foreign objects in EVERYTHING produced and packaged in the USA. It happens. You guys act like Chinese steroids are the only thing you have to be scared of. Get a grip. Everyone here is injecting liquids they got in the mail from a total stranger.
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Yea bro seeing this all day every day from sources. Don't be scared. Pin it you fanny
 

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Missingintheabyss said:
Yea bro seeing this all day every day from sources. Don't be scared. Pin it you fanny
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I didn't say you see that everyday from sources. You don't see that everyday from this source. I obviously wouldn't use that. But what about the 1000 other ones that were fine? How many times has your favorite food from the grocery store been recalled because metal was found in one bag. Bet you didn't go in strike then. I'm just saying it happens. Do your own research and inject what you want to. Think it through. You don't know any of the sources personally and you didn't test every substance before using. Your favorite source could skip their meds one day and decide "fuck it, Im putting fent in everyone's test today" It's all a risk.
 
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Jpxxx said:
And what happens when something is found in food? Theres a recall. But here there is no recall. We have to decide for ourselves. I made my choice, youre free to make yours
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Exactly!! That's what I said I'm my other post. You have to use your own discernment and understand it's all a risk. Obviously don't use that vial. But throw the baby out with the bath water? I don't know. That's a personal choice.
 
CtotheP said:
Exactly!! That's what I said I'm my other post. You have to use your own discernment and understand it's all a risk. Obviously don't use that vial. But throw the baby out with the bath water? I don't know. That's a personal choice.
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U think its just 1 vial eh? Im not risking it, that said i got shit luck getting anything through customs anyways lmao. So ill stick to domestic sources
 
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