MESO-Rx
Anabolic Steroids
Wuhan Wansheng Biotechnology Co., Ltd. (USA, International)
- Thread starter Wansheng Biotechnology
- Start date
lol ok
No I understand what it is, but if you have a USPS tracking number waiting on the item to be received, how does that tracking number track whatever they use before it gets here? Just a question since I haven't had to use it yet.
Edit: never mind. I just put in my tracking number and information came up that wasn't there before. I get it now. I just have been using a different king trans earlier because it wasn't working. Turns out mine only sat in customs for 6 days from this other source. 15 days from order to receive. Not bad I guess. Thanks.
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tweek
Member
Finnrick states that it only accepts samples from within the us so I'd just have to go with janoshik unless there's something in Canada lol
High dose sure does something I'm just not sure if I'm a fan yet
im on 15mg weekly, dont think i could tolerate that from week 1
Missingintheabyss
Member
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BigBoy0689
New Member
Hi everyone,
has anyone tested the current Drostanolone E?
Best regards
has anyone tested the current Drostanolone E?
Best regards
47Ronin
Member
On a real note…wtf is that? I would not inject that oil into my body. Even after filtering. I have never even seen a floater in 1 bottle that bought from anybody ever. I know it happens from time to time but that is ridiculous!!! How does that even happen
47Ronin
Member
There were some tests. They came out fine. Id have to do a little digging to find them for you.
Raww
Member
"GI side effects (nausea, vomiting) are intense initially but fade quickly due to tachyphylaxis (rapid adaptation) to gastric emptying slowdown.
Core effects—appetite suppression, glucose control, weight loss—show no true pharmacological tolerance in long-term human trials (SURPASS/SURMOUNT extensions, 1–2+ years). Sustained efficacy at stable/max doses; plateaus occur from reaching a new metabolic set point, not drug failure."
Your dose now is without the extreme sides because titration builds tolerability while the mechanism remains active.
47Ronin
Member
Of course you can have tolerance for GLP that’s why they increase your dose every four weeks. I remember the first time I ever did Sema, I accidentally did 1 mg instead of .25 mg and within a few hours, I was violently puking everywhere. Within 8 weeks I was up to 1 mg and only suffered the usual side effects. Diarrhea, no appetite and upset stomach that usually only lasted 2 days. Eventually, I was at the full dose and I barely had any side effects at all.
Random fact, I know Sema is the weakest of the 3 main glps out right now but I able to lose 40 lbs in 2 months on it. I was also dieting eating very clean and going to the gym every day for almost 2 hours, but had I not had the medication I probably would’ve lost maybe only 15 pounds. I had to cut fast for an abdominal surgery that was a success lol. Not sure why I had to throw it in there, but it felt good lol
You just ate your own words lmao
100%. Your body builds tolerance to just about any drug.
Raww
Member
No, that's not eating my own words.
- Tachyphylaxis → rapid adaptation (days/weeks) → mainly to GI side effects (nausea, vomiting) and gastric emptying slowdown (fades quickly with long-acting GLP-1s like tirzepatide/semaglutide).
- True pharmacological tolerance → gradual loss of core efficacy (appetite suppression, glucose control, weight loss) over months/years → does not occur in human trials.
SURPASS/SURMOUNT extensions show sustained effects at stable/max doses for 1–2+ years: continued weight loss/maintenance, no evidence of the mechanism quitting. Plateaus happen because the body adapts metabolically (new set point, reduced energy expenditure, etc.), not because the drug loses potency.
Titration lets you reach high doses without extreme sides precisely because tachyphylaxis handles tolerability while the primary actions stay active. That's the exact opposite of tolerance killing efficacy.
Raww
Member
If true pharmacological tolerance developed to GLP's, the drug's core effects would gradually weaken over time—even while continuing the same dose. This would mean the appetite suppression, satiety signals, and glucose regulation would fade, leading to increased hunger, higher calorie intake, and weight regain while still on the medication.
That's not what the evidence shows in long-term studies (e.g., STEP and SURMOUNT extensions, up to 2+ years).
Instead:
This happens because GLP-1 agonists don't simply "force" weight loss. They act on brain and gut pathways to mimic signals that tell your body it's at a certain weight level—adjusting hunger, fullness, and energy use accordingly. The medication effectively shifts your body's defended "set point" (or settling point) downward. Once you reach a new equilibrium at that lower weight:
A plateau reflects the balance—not the drug losing effectiveness. True tolerance would cause the signals to weaken, hunger to return, and weight to climb back up despite ongoing treatment. Studies confirm that doesn't occur; regain typically happens only after discontinuation.
That's not what the evidence shows in long-term studies (e.g., STEP and SURMOUNT extensions, up to 2+ years).
Instead:
- Weight decreases steadily at first.
- Then it levels off into a plateau—no further loss, but also no regain as long as the drug is continued at a stable dose.
- People maintain the lower weight for extended periods (often 1–2+ years in trials), with sustained appetite control and metabolic benefits.
This happens because GLP-1 agonists don't simply "force" weight loss. They act on brain and gut pathways to mimic signals that tell your body it's at a certain weight level—adjusting hunger, fullness, and energy use accordingly. The medication effectively shifts your body's defended "set point" (or settling point) downward. Once you reach a new equilibrium at that lower weight:
- Energy intake matches the reduced energy expenditure (a smaller body burns fewer calories at rest due to normal metabolic adaptation).
- The drug continues sending appropriate signals for that new level, preventing rebound hunger or regain.
A plateau reflects the balance—not the drug losing effectiveness. True tolerance would cause the signals to weaken, hunger to return, and weight to climb back up despite ongoing treatment. Studies confirm that doesn't occur; regain typically happens only after discontinuation.
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