Has somebody tried Increlex?

[Proud Pangolin]

So what i read is that Increlex is suppose to be "the real deal" and playing in a completely different league than IGF1 LR3, because Increlex contains IGF1 that is identical to the human endogenous IGF1 , while the IGF1-lr3 is a configuration of the IGF1 molecule.

Skip to the end for the short version

(However i have to read more into this because free natural igf-1 has a hl of only 10min while bindes igf-1 has a hl of 12h ane Increlex simply has a hl of 5,8h)

And im also jot really a big fan of the halflife of 30h of IGF1 LR3. First of all this does obviously lead to fast receptor desensitization which i find critical especially considering the fact that it differs significantly from your natural igf-1 in its chemical structure.

Second of all of i want generally high systemic igf-1 levels im just going to take GH.

What im actually interested in is using Increlex for local growth. So tge idea is, lets say your bizeps is your weakspot.

Then you will inject once a week one day after you trained biceps IM in the biceps.
(One day after because thats when natural igf-1 would start beeing released, we dont want to get in the way of the early stage MGF which again is a reason i think LR3 doesnt work well).

Now I DO realise that something with a 5hour half life will go systemic to some degree but i still think you will get primarly a local growth and that without completely fucking over your GH receptors in your whole body hopefully(?)

So the question basically is: has anybody tried Increlex?
Is it overhyped? Worth the money of you can afford it? What do you thing about my idea? Bullshit or could work?

 

[Ateam2023]

So what i read is that Increlex is suppose to be "the real deal" and playing in a completely different league than IGF1 LR3, because Increlex contains IGF1 that is identical to the human endogenous IGF1 , while the IGF1-lr3 is a configuration of the IGF1 molecule.

Skip to the end for the short version

(However i have to read more into this because free natural igf-1 has a hl of only 10min while bindes igf-1 has a hl of 12h ane Increlex simply has a hl of 5,8h)

And im also jot really a big fan of the halflife of 30h of IGF1 LR3. First of all this does obviously lead to fast receptor desensitization which i find critical especially considering the fact that it differs significantly from your natural igf-1 in its chemical structure.

Second of all of i want generally high systemic igf-1 levels im just going to take GH.

What im actually interested in is using Increlex for local growth. So tge idea is, lets say your bizeps is your weakspot.

Then you will inject once a week one day after you trained biceps IM in the biceps.
(One day after because thats when natural igf-1 would start beeing released, we dont want to get in the way of the early stage MGF which again is a reason i think LR3 doesnt work well).

Now I DO realise that something with a 5hour half life will go systemic to some degree but i still think you will get primarly a local growth and that without completely fucking over your GH receptors in your whole body hopefully(?)

So the question basically is: has anybody tried Increlex?
Is it overhyped? Worth the money of you can afford it? What do you thing about my idea? Bullshit or could work?

Luki on another forum actually just spoke about this , something about the increlex being wayyy overpriced because its "pharma" and maybe the dac version of lr3 being just as effective and cheaper , @AlexDavis43 does lr3 i believe? maybe he has some information he can share

 

[Elektrobot]

I've only heard people say they get bigger pumps on lr3, and I wonder if its just the insulin like effect. I haven't heard anyone say they put on actual tissue with lr3

 

[AlexDavis43]

Luki on another forum actually just spoke about this , something about the increlex being wayyy overpriced because its "pharma" and maybe the dac version of lr3 being just as effective and cheaper , @AlexDavis43 does lr3 i believe? maybe he has some information he can share

I think that's the thing, pharma vs UGL

Some people will say nothing is as good as Increlex just like some people say pharma GH is better than UGL

 

[frenexen]

LR3 does NOT have a long half life. It has reduced binding to IGFBPs and actually has a really short half-life. It would be preferred for site enhancement, but probably still a waste of money.

Also, the half-life of endogenous IGF-1 is irrelevant because of IGFBPs.

GH is so cheap, it is by far the most effective way to increase IGF-1. The only use case for increlex would be if you can't figure out how to tolerate GH side effects/ insulin sensitivity, or during off periods to sensitize GHR.

 

[Ateam2023]

LR3 does NOT have a long half life. It has reduced binding to IGFBPs and actually has a really short half-life. It would be preferred for site enhancement, but probably still a waste of money.

Also, the half-life of endogenous IGF-1 is irrelevant because of IGFBPs.

GH is so cheap, it is by far the most effective way to increase IGF-1. The only use case for increlex would be if you can't figure out how to tolerate GH side effects/ insulin sensitivity, or during off periods to sensitize GHR.

i thought the whole point of lr3 etc was site enhancements for a lagging muscle? I dunno its above my paygrade.

 

[frenexen]

i thought the whole point of lr3 etc was site enhancements for a lagging muscle? I dunno its above my paygrade.

Theoretically yeah. I say probably a waste of money because I’ve yet to see any actual good results from it. You’d probably have to use a significant amount of it to see results, if any.

 

[AlexDavis43]

i thought the whole point of lr3 etc was site enhancements for a lagging muscle? I dunno its above my paygrade.

Theoretically (bro science), DES is for site enhancement, not LR3

I use LR3 and it's not a local effect - muscle pumps are full body, not just the muscle you trained that day

 

[beorn777]

Roman Fritz got real increlex at one point and said he got leaner and harder and it was like magic eating a ton of food but he eventually had to get surgery because he developed nerve issue's in his hands from the growth. It seems risky and extremely expensive.

 

[AlexDavis43]

Roman Fritz got real increlex at one point and said he got leaner and harder and it was like magic eating a ton of food but he eventually had to get surgery because he developed nerve issue's in his hands from the growth. It seems risky and extremely expensive.

Fritz really pushes the envelop with some compounds

When he said his insulin dose, I don't recall the IU but my first thought was "PER DAY??" (it was high)

Did he say his dose of Increlex? I wouldn't be surprised if dosed it way higher than other bodybuilders

 

[AlexDavis43]

Theoretically yeah. I say probably a waste of money because I’ve yet to see any actual good results from it. You’d probably have to use a significant amount of it to see results, if any.

If by "significant amount" you mean "don't microdose it," then yeah

Everyone is so used to seeing 0.25 mg/d, that they think 0.5-1 mg/d is way too high (it's not)

Maybe it's too expensive for people to run efficacious doses in the ballpark of 0.5-1 mg/d, but that doesn't mean the compound is ineffective, just expensive (surprise surprise)

 

[beorn777]

Fritz really pushes the envelop with some compounds

When he said his insulin dose, I don't recall the IU but my first thought was "PER DAY??" (it was high)

Did he say his dose of Increlex? I wouldn't be surprised if dosed it way higher than other bodybuilders

1mg daily

250 pre and post workout but he trains twice a day.

Its in the vigorous steve roman fritz interview on YouTube if your curious.

Yeah I love roman he told me to pick two compounds in the off-season and make sure the vials gone each week...

 

[AlexDavis43]

1mg daily

250 pre and post workout but he trains twice a day.

Its in the vigorous steve roman fritz interview on YouTube if your curious.

Yeah I love roman he told me to pick two compounds in the off-season and make sure the vials gone each week...

Thanks

1 mg is on the high end for normies but not too crazy for a beast like Roman

 

[Ateam2023]

Theoretically (bro science), DES is for site enhancement, not LR3

I use LR3 and it's not a local effect - muscle pumps are full body, not just the muscle you trained that day

My mistake , i really have no clue honestly, I don't use either , outta my wheelhouse, sorry for misleading information everybody , Thanks @AlexDavis43 for the correction.

 

[Zeus45]

IGF1LR3 is good stuff if you have trouble converting GH to IGF1

 

[Proud Pangolin]

LR3 does NOT have a long half life. It has reduced binding to IGFBPs and actually has a really short half-life. It would be preferred for site enhancement, but probably still a waste of money.

Also, the half-life of endogenous IGF-1 is irrelevant because of IGFBPs.

GH is so cheap, it is by far the most effective way to increase IGF-1. The only use case for increlex would be if you can't figure out how to tolerate GH side effects/ insulin sensitivity, or during off periods to sensitize GHR.

Sorry to ask this so bluntly but do you have any sources for this statement? Because everywhere i read LR3 has a halflife of 20-30h.

Also i want to emphasis again that im not interested in general sytemic anabolism through igf-1 but in local growth. Take me for example: my biceps is my weakspot. Everyone has one and believe me if i tell you i tried everything: high reps, low reps, high weight, low weight, HIT, Volumentraining, much rest, less rest.... and while i made progress it still remains a weakspot.

And as long as you arent a genetic monster everyone probably knows what im talking about. So thats why im interested in: can we force local growth???

PEG MGF is suppose to achieve it according to experineces but again im concerned with tge systemic effect and especially effects on the heart with PEG MGF. Increlex on the other hand is approved and also the actual igf-2 variant that is responsible for cell proliferation.

So yes i agree, for general systemic anabolism go with GH, but thats not my interest here

 

[Proud Pangolin]

Theoretically (bro science), DES is for site enhancement, not LR3

I use LR3 and it's not a local effect - muscle pumps are full body, not just the muscle you trained that day

My concern with DES is the TO SHORT halflife. So this are just my thoughts but:
The half life is 20-30min. The affinity is 10x higher than natural igf-1.

So my my concern is that while the anabolic action is very short, it will result in a significant receptor desensitization. Which we dont want because we also want our natural igf-1 working.

So thats why the halflife of Increlex isnso appealing to me. Not to long, not to short

 

[Proud Pangolin]

Luki on another forum actually just spoke about this , something about the increlex being wayyy overpriced because its "pharma" and maybe the dac version of lr3 being just as effective and cheaper , @AlexDavis43 does lr3 i believe? maybe he has some information he can share

What forum? I would like to read it

 

[Biglittlejoe]

I like the effects of IGF-1 LR3 but my fear of cancer proliferation prevents me from using it anymore. At 54, I likely have some cancerous or precancerous tissue in my prostate. The same fear would apply to increlex. My understanding is that HGH is safer because of the binding of the IGF-1 metabolites to globulins regulating the action- but it has been a while since I researched this so I can’t remember the details.

 

[Ateam2023]

What forum? I would like to read it

It was actually on his yt channel ,
View: https://youtube.com/watch?v=6kKAita9Ce8&si=6f_vfa5vsimp7mMw

"True Bodybuilding" i think its called