Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[dontyellmepls]

Would jumping from 10mg Tirz straight to 15mg be an issue. I wanna skip 12.5 because I think it wouldn't make much difference and the hunger is a bitch now.
I did the same going from 5 to 10 and it was alright. (I technically did 1 week on 7.5mg but felt no difference compared to 5mg so I then went straight to 10mg).
My eating has been complete shit recently so I wanna put a stop to it ASAP

Expect some serious constipation

 

[Luke391]

Expect some serious constipation

really? I didn't get any side effect jumping from 5 to 10

 

[dontyellmepls]

really? I didn't get any side effect jumping from 5 to 10

I did....

 

[Luke391]

I did....

what's your current dose?
If 15mg became my maintnance it wouldn't be an issue right?

 

[Ghoul]

what's your current dose?
If 15mg became my maintnance it wouldn't be an issue right?

It'll probobly be fine.

GLPs reduce thirst as much as hunger, and that's the main cause of constipation, so just consciously get enough to drink.

 

[Earthworm Jim]

what's your current dose?
If 15mg became my maintnance it wouldn't be an issue right?

How much weight had you lost before hopping on glp-1? These things are miracles but you can achieve your goals without them.

I recently ran out of reta, so I took my dosage down and spaced it out a little more than I had been doing, to make the vial go farther. This was in my best interest because I was conscious of the boost in appetite suppression enough to appreciate it but I was also able to defeat the purpose of the reta when some irresistible cake came around. So it helped me get my mental game back to where it was when I was steadily losing weight the old fashioned way, before knowing about GLP-1

 

[Luke391]

How much weight had you lost before hopping on glp-1? These things are miracles but you can achieve your goals without them.

I recently ran out of reta, so I took my dosage down and spaced it out a little more than I had been doing, to make the vial go farther. This was in my best interest because I was conscious of the boost in appetite suppression enough to appreciate it but I was also able to defeat the purpose of the reta when some irresistible cake came around. So it helped me get my mental game back to where it was when I was steadily losing weight the old fashioned way, before knowing about GLP-1

I don't think I can loose weight without GLPs anymore. Before them I lost weight multiple times (I think 4 or 5 times) but every times regained it because it was unsustainable. Even with slow weight loss and everything right I could keep the weight off for 2-6months maximim before burning out and regaining all the weight.
I think that all those years of being hungry all the time got me to a point where mentally I just can't really deal with hunger anymore because there's no point.
Like I know that my body will not get used to being leaner and the hunger will not subside so if I'm hungry Imma just eat because it's pointless effort otherwise.
Being hungry to be leaner is not a worth trade off I realized, it makes everything terrible.
So either I go the GLP1 route or I don't wanna waste my willpower pointlessly with a diet that will only make my life worse.
Having a good quality of life phiscially and mental has become my priority so I a diet without GLPs is not worthwhile anymore

 

[Photon]

Would jumping from 10mg Tirz straight to 15mg be an issue. I wanna skip 12.5 because I think it wouldn't make much difference and the hunger is a bitch now.
I did the same going from 5 to 10 and it was alright. (I technically did 1 week on 7.5mg but felt no difference compared to 5mg so I then went straight to 10mg).
My eating has been complete shit recently so I wanna put a stop to it ASAP

You can always try, i don't know about Tirz but i've done it by accident on reta..

Few months ago i took a whole vial (30mg) instead of 1/2 of it because i was half alsleep. Did it recently, was supposed to be injecting 18mg for the past few weeks but realized Ive been doing close to 22mg..Makes me wonder if i should just go straight to 20mg now.

These usually take a few weeks to build up, so if ur experiencing unwanted unbearable sides you can always back off the next week by taking less which evens it out.

 

[Luke391]

You can always try, i don't know about Tirz but i've done it by accident on reta..

Few months ago i took a whole vial (30mg) instead of 1/2 of it because i was half alsleep. Did it recently, was supposed to be injecting 18mg for the past few weeks but realized Ive been doing close to 22mg..Makes me wonder if i should just go straight to 20mg now.

These usually take a few weeks to build up, so if ur experiencing unwanted unbearable sides you can always back off the next week by taking less which evens it out.

damn. 30mg Reta gotta be rough

 

[Liter O' Test]

Would jumping from 10mg Tirz straight to 15mg be an issue. I wanna skip 12.5 because I think it wouldn't make much difference and the hunger is a bitch now.
I did the same going from 5 to 10 and it was alright. (I technically did 1 week on 7.5mg but felt no difference compared to 5mg so I then went straight to 10mg).
My eating has been complete shit recently so I wanna put a stop to it ASAP

dude you have body dysmorphia and an eating disorder. stop

 

[Iksrohcic1]

Started 2mg of reta on Wednesday and on Sunday which is 5 days later I broke out in a rash, hives and wheals. No history of any allergies and got it from a reputable source. Switched laundry detergent too but it’s going other places where clothing doesn’t touch which is making me think it could be the reta? I’ve taken H1 blockers and hydrocortisone cream to help with the symptoms. Wondering if this is common or something I can manage and continue to take.

 

[BrunoES]

dude you have body dysmorphia and an eating disorder. stop

View attachment 351660

If thats him, I would highly advise him to seek professional help. He does not want to go down that road.

 

[Luke391]

dude you have body dysmorphia and an eating disorder. stop

View attachment 351660

when you're lean on grams of gear it's "great work bro" when you are not on grams of gear "you have a problem".
don't pretend like anyone in the bodybuilding community is any different. I just haven't started blasting yet

 

[Liter O' Test]

when you're lean on grams of gear it's "great work bro" when you are not on grams of gear "you have a problem".
don't pretend like anyone in the bodybuilding community is any different. I just haven't started blasting yet

the difference is you do not know how the body works and think food is bad, you dont know what health is or what youre doing to yourself


many many people have told you this about 1 month ago.

I'm on 10mg and will keep upping the dose, but the question is: could using one of the supplements/drugs I listed in the title help to restore insulin sensitivity and the metabolic damage and inflammation caused by the binge episodes? Not used chronically, but only after the instances of overeating using like 1000-1500mg of Berberine phytosome or 500mg Metformin or 200-400g Acarbose (just one, not all 3 togheter)

Does it make sense or no? Possible drawbacks? I know metformin and berberine are a mithocondrial toxin and that acarbose is linked to decreased strenght, but I was thinking the intermittent use and the addition of mithocondrial efficiency supplements and peptides (like carnitine, coQ10 and mots-c) could limit the negatives.

I definetly had poor insulin sensitivity before Tirzepatide, now I belive it's improved because after the binged I notice a bit less less water/fat retention than I used. But I still think it's far from optimal. Years and years of binging on shit food fucks with insulin sensitivity and many other processes, I fast regularly and that helps but still probably not enough.

I think I am chronically inflamed because I have had almost constant brainfog and "fibromyalgia" (if you wanna consider it a real thing) for a long time.
I'm taking NAC, vitamin C and a little Omega3 but I think I need something to counter in an acute way the negatives of the food benders.

also I think I have more visceral fat that I'd like, because even after fasting my stomach isn't super flat. I don't have a gut but it's not perfectly flat either

you have brainfog because youre starving yourself, not because food is "making you inflammed" lol

I don't think I'm that lean. I carry a fuck ton of fat on my legs so I'm probably around 12-14%.
The light in those pics is maybe a bit too flattering.

I'm actually scared of this shit. I litterally rely on GLP1s and mitochondrial peptides to even function as a human being in society.
I think I wouldn't even be able to hold down a job or be a normal person without this stuff

I mean it's not really fun. I care about my health and I know how damaging it is to binge or eat junk and mentally it makes me feel shitty afterwards. And I do a lot to stay lean.
My initial question was about reducing the metabolic damage.
I posted pictures only to avoid the whole "just be disciplined fatass"

for me it's like one thing leads to another. Like I usually put off eating until I have to train, or on reat days I might even do OMAD since I find fasting pretty easy.
But once I start I get even hungrier. Like I'll eat vegetables, then meats, then eggs or yogurt with fruit and then I'll be craving all sorts of shit.

nice. how would you see a 3 day fast to quickly get in ketosis before starting keto diet?

How would you guys say a stack of Tirz + Mazdutide would compare to Reta?
I'd like more appetite suppression as well as glucagon agonism

hey any tips to get trough the fast? I always break on the 2nd day. The few times I did get trough the second day I couldn't sleep at night and would end up getting up at 2 am to eat the kitchen

L

Post in thread 'Berberine/Metformin/Acarbose to reduce metabolic damage from binge eating?'

Aug 31, 2025

This is extremely lean.

I don't think I'm that lean. I carry a fuck ton of fat on my legs so I'm probably around 12-14%.
The light in those pics is maybe a bit too flattering.

• Luke391

• 

 

[Liter O' Test]

I've been cutting down from above 30% bodyfat. Currently 15%ish I belive? thing is my face looks way leaner than my body, my cheeck bones are very prominent and my face is a little sunken. I've always had a lean face, even when I was obese my face wasn't nearly as fat as my body. But now I've had family members worry and bother me because of it. Phisically I look perfectly fine, just my face is "too lean". Can Collagen help? or even injecting GHK-cu directly in the cheeks?

 

[Liter O' Test]

 

[The Answ3r]

when you're lean on grams of gear it's "great work bro" when you are not on grams of gear "you have a problem".
don't pretend like anyone in the bodybuilding community is any different. I just haven't started blasting yet

Hold up, man. I really thought from your posts that you were overweight, struggling with food, no control, all that. But looking at this picture? You’re lean as hell, under 10% body fat, shredded. Where the fuck are you even trying to lose more from? This isn’t discipline anymore, this is body dysmorphia in full swing. I expected a guy with three rolls on his stomach, but instead you look like you’re stage-ready. You don’t need another GLP-1, you need to sit down with a specialist and fix what’s going on in your head before you push yourself past the edge. Not mocking you, just telling you straight: you’re already way past the line.

 

[newguy2]

Hold up, man. I really thought from your posts that you were overweight, struggling with food, no control, all that. But looking at this picture? You’re lean as hell, under 10% body fat, shredded. Where the fuck are you even trying to lose more from? This isn’t discipline anymore, this is body dysmorphia in full swing. I expected a guy with three rolls on his stomach, but instead you look like you’re stage-ready. You don’t need another GLP-1, you need to sit down with a specialist and fix what’s going on in your head before you push yourself past the edge. Not mocking you, just telling you straight: you’re already way past the line.

Agreed those posts are troubling.

 

[serk1]

How long can unreconstituted semaglutide powder sealed in vial be stored without losing its potency or effectiveness?

 

[Ghoul]

How long can unreconstituted semaglutide powder sealed in vial be stored without losing its potency or effectiveness?

How long is a piece of string?

Seriously, where is it being stored? In or out of light? Room temp or refrigerated?