MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Earthworm Jim
Member
This guy says his patients lose a pound a day of mostly fat by water fasting
View: https://open.spotify.com/episode/6nJR8HaQpqf33rbjjZHpq1?si=U-86n09gRQmlvYGGpEEqGQ
View: https://open.spotify.com/episode/6nJR8HaQpqf33rbjjZHpq1?si=U-86n09gRQmlvYGGpEEqGQ
Earthworm Jim
Member
Minus 30 pounds later.... I can do all things through Christ
I did Mazdutide a while back with QSC. At first I liked it. It worked fine. It seemed to get “stronger” towards the end of the week. When QSC shut down, I couldn’t find maz anywhere. I decided to go back to tirze. Tirze is much better now that I’ve compared. More appetite suppression and less inflammation. I won’t go back to Maz again.
bananafeet
Member
I'll have to try tirz again without HGH. The issue I had on tirz was massive fatigue.
Liter O' Test
Member
i just wanna let you know keto is bullshit, the body doesnt just pick one energy source to use. just eat normal, your on GLPs aswell..
and stop posting the diet stuff that pops up in your fat guy algorithim . this is a bodybuilding forum
no kidding you lose a lb a day by not eating. this is basic stuff, dont need to see it here or encourage people to starve themselves on GLPS because they dont know how the body or food works
Photon
Member
Keto
Staying on the keto diet long term could carry health risks
Months on a high-fat keto diet put mice at risk for cardiovascular disease and impaired insulin secretion.
www.sciencenews.org
nice. how would you see a 3 day fast to quickly get in ketosis before starting keto diet? I don't feel like going trough the acward transition phase where I feel shitty cause no carbs but still not getting the benefits of ketosis.
Fasting would also be great for authophagy and longevity so it seems like a win-win to me?
well I see fasting as more of a tool for restoring various health metrics (insulin sensitivity, clearing apoptotic and scenesceant cells, reducing visceral fat, lowering inflammation, inhibiting mTOR and activatinf AMK, inducing hermesis).
Fasting for even 5-7 days you won't loose a crazy amount of sibcutaneous fat. you'll loos a ton of weight but that's just glycogen stores, water weight and poop, and a little visceral fat. relativly little subQ fat
it's a valid concern but likely it wouldn't manifest until a VERY long time on Keto in humans. 1 year for a lab mouce is like half of their life I think. That's like going 35-40years with no carbs and seeing issues.Keto
Staying on the keto diet long term could carry health risks
Months on a high-fat keto diet put mice at risk for cardiovascular disease and impaired insulin secretion.
View attachment 349643
I think a more short-medium term approach to keto (like doing it for 3-4montha every year) might be more benficial for metabolic flexibility and many other benefits that will lower your rate of disease and mortality likelihood as you go
Liter O' Test
Member
whole lot of nonsense from your "feelings".
everyone here is smarter than you on this topic.
stop posting your "hunches" based on absolutely nothing,
because you are completely wrong and your words have zero value
"mEtAbolIC fLeXaBiLITY"
please keep this thread to GLPs.
they do everything you need them to do
no extreme fad diets necessary
BrunoES
Member
Tirz update from first 2.5mg shot:
I took my first dose on Thursday at 3 PM (2.5 mg). As of this morning (Monday, 6 AM), it’s been about 87 hours. Last night was the first night I didn’t experience any burping. This morning, I had my first solid bowel movement—no diarrhea, no intestinal discomfort, no cramps.
In terms of appetite, I’d say it has been suppressed by about 15% since the very first dose. Based on that, I’m assuming that once this dose reaches its full effect, I’ll probably have the level of suppression I was aiming for—which is simply being able to treat eating like work. Weight a little up, still 5lbs to get back to pre-shot weight.
I took my first dose on Thursday at 3 PM (2.5 mg). As of this morning (Monday, 6 AM), it’s been about 87 hours. Last night was the first night I didn’t experience any burping. This morning, I had my first solid bowel movement—no diarrhea, no intestinal discomfort, no cramps.
In terms of appetite, I’d say it has been suppressed by about 15% since the very first dose. Based on that, I’m assuming that once this dose reaches its full effect, I’ll probably have the level of suppression I was aiming for—which is simply being able to treat eating like work. Weight a little up, still 5lbs to get back to pre-shot weight.
Could one get similar effects to Reta by adding Mazdutide or Survodutide on top of Tirz? since they are GLP1 + Glucagon agonists they don't add extra GIP burden.
The benefits of Glucagon are very attractive but I did well with tirz so far so I don't wanna trow it out completely and restard the whole thing with Reta.
Does anyone know of Maz or Survo have higher or lower affinity for Glucagon receptor compared to Reta? I assume lower but I've seen chart showing both higher affinity and lower affinity than reta.
Also, why does Reta outperform all other GLPs when most report weaker appetite suppression? is the BMR increase that significant?
The benefits of Glucagon are very attractive but I did well with tirz so far so I don't wanna trow it out completely and restard the whole thing with Reta.
Does anyone know of Maz or Survo have higher or lower affinity for Glucagon receptor compared to Reta? I assume lower but I've seen chart showing both higher affinity and lower affinity than reta.
Also, why does Reta outperform all other GLPs when most report weaker appetite suppression? is the BMR increase that significant?
Ghoul
Member
Reta more effectively suppresses the metabolic adaptation of Sema and Tirz.
In other words, as food intake goes down, the body responds by slowing base metabolism to conserve calories.
Even without "extra" calorie burning from glucagon (which is minimal even at high doses), the slowdown is blunted, so more calories are being burned at rest than is at the same calorie intake reduction using Sema and Tirz.
There's a point at higher Reta doses, probobly around 8-10mg, where base metabolism matches the rate it was before any weight was lost. That's most likely due to the glucagon thermogenesis effect manifesting itself at those doses, increasing calorie burn.
For completeness, fyi Sema and Tirz also blunt metabolic adaptation compared to caloric reduction using standard dieting, but not as much as Reta does.
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Deadpool99
Member
This is a giant ass thread so pardon me if this was previously asked.
I have a question @Ghoul . At 15mg reta, I feel like I shouldn't up the dose any further and if it call for more appetite suppression I'm adding in some cagri,.
But in terms of insulin sensitivity, is it worth switching to tirz on a 15mg reta dose. I have reta stocked for a couple of months and as my first glp1 I rly like it and got comfortable with the dosing.
But if there is noticeable difference in switching, I'd consider it. BG is fine now, optimal, but going to blast some hgh and wondering since u always mention tirz being better.
Dropped Tirz from 15mg to 10mg and thought everything was smooth, but now I’m getting random nausea, especially in the mornings. For example, I’ll have breakfast, then slam my L-citrulline with some water 30-40 minutes later and suddenly I’m gagging like I just smelled ammonia caps. Same thing if I chug too much water during the day, my stomach acts like I tried to drown myself.
On top of that, I’ve been off HGH for about a month now and it feels like my blood sugar dips too low, which is a new kind of fun. Already did bloodwork and waiting on results to see what’s really going on. This whole thing is turning into a fun experiment, but hey, at least it keeps life interesting.
On top of that, I’ve been off HGH for about a month now and it feels like my blood sugar dips too low, which is a new kind of fun. Already did bloodwork and waiting on results to see what’s really going on. This whole thing is turning into a fun experiment, but hey, at least it keeps life interesting.
Ghoul
Member
At 15mg Reta I don't think there's anything significant to gain by switching to Tirz in terms of glucose control. Most people are using far smaller doses, where the difference is more pronounced.
How would you guys say a stack of Tirz + Mazdutide would compare to Reta?
I'd like more appetite suppression as well as glucagon agonism but I domn't want more GIP agonism (impared digestion but still high hunger).
Questioning id I should add Maz or completely switch to Reta
I'd like more appetite suppression as well as glucagon agonism but I domn't want more GIP agonism (impared digestion but still high hunger).
Questioning id I should add Maz or completely switch to Reta
bananafeet
Member
Reta has poor appetite suppression. The glucagon thing isn't that great just gives you more energy and you forget about food if you're busy.
You'd be better off adding in a different suppression pathway like cagrilinitide.
Ghoul
Member
I don't think you want to fuck with glucagon by throwing. together random compounds. Other glucagon drugs failed in early trials due to safety issues, You can't just increase it randomly and assume it's safe.
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