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Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

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Anyone else thinks that Tirzepatide works not only by supressing appetite, but it also increase calorie expenditure or reduces the absorbtion of food in some way? Or maybe it improves nutrient partitioning in a very significant way?
Similar to how the Glucagon agonism of Reta increases calorie expenditure? I didn't notice this on the lower doses, like 2.5-5mg, but since getting to the higher doses of 10mg and now 12.5mg I do.
Like by now I can eat as much as I want with no appetite suppresion, but even if I binge eat on a very large amount of calories the next day I gain very little weight, and it seems to be just water since it goes away in a day or 2.

The past 2 day I overate quite bad, after the 1st day of overeating I woke up the same weight as before, I ended up overeating the next day also and even got a stomach ache on both day, quite a bad one at that (I'm a degenerate I know). I didn't weight myself the next day cause I'd have felt shitty. Let 1 day go by and weighed myself this morning and I am 0.5lbs lighter than before this whole binge episode?

Also the improved insulin sensitivity I have noticed from the 10mg dose onward has been amazing. I'm exited to go up to 15mg next week, to see if these benefits of better nutrient partitioning and metabolic health keep increasing.

I've been at 10mg for a while and was debating if I should add Cagrilintide or up Tirzepatide to 15mg. Cagrilintide was looking very attractive to me but after taking note of these benefits from the Tirz (outside of the appetite suppression) I have decided to just up it
 
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Luke391 said:
Anyone else thinks that Tirzepatide works not only by supressing appetite, but it also increase calorie expenditure or reduces the absorbtion of food in some way? Or maybe it improves nutrient partitioning in a very significant way?
Similar to how the Glucagon agonism of Reta increases calorie expenditure? I didn't notice this on the lower doses, like 2.5-5mg, but since getting to the higher doses of 10mg and now 12.5mg I do.
Like by now I can eat as much as I want with no appetite suppresion, but even if I binge eat on a very large amount of calories the next day I gain very little weight, and it seems to be just water since it goes away in a day or 2.

The past 2 day I overate quite bad, after the 1st day of overeating I woke up the same weight as before, I ended up overeating the next day also and even got a stomach ache on both day, quite a bad one at that (I'm a degenerate I know). I didn't weight myself the next day cause I'd have felt shitty. Let 1 day go by and weighed myself this morning and I am 0.5lbs lighter than before this whole binge episode?

Also the improved insulin sensitivity I have noticed from the 10mg dose onward has been amazing. I'm exited to go up to 15mg next week, to see if these benefits of better nutrient partitioning and metabolic health keep increasing.

I've been at 10mg for a while and was debating if I should add Cagrilintide or up Tirzepatide to 15mg. Cagrilintide was looking very attractive to me but after taking note of these benefits from the Tirz (outside of the appetite suppression) I have decided to just up it
Click to expand...
You're probably not over eating as much as you imagine do to the appetite suppression.
 
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HotPepper said:
Is there any benefit If you combinate Sema, Tirza or/and Retra?

From my point of view just to reduce the Sides.
Click to expand...

NO.

Pick one, follow the pharma protocol, and you'll get the proven pharma results.

Sides are short lived when you stick to the program.

It's all the amateur reddit biopharmaceutical engineers who think their guesswork is better than billions in research and proven results. Yet those are the folks endlessly suffering sides and get the worst results,
 
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Luke391 said:
Anyone else thinks that Tirzepatide works not only by supressing appetite, but it also increase calorie expenditure or reduces the absorbtion of food in some way? Or maybe it improves nutrient partitioning in a very significant way?
Similar to how the Glucagon agonism of Reta increases calorie expenditure? I didn't notice this on the lower doses, like 2.5-5mg, but since getting to the higher doses of 10mg and now 12.5mg I do.
Like by now I can eat as much as I want with no appetite suppresion, but even if I binge eat on a very large amount of calories the next day I gain very little weight, and it seems to be just water since it goes away in a day or 2.

The past 2 day I overate quite bad, after the 1st day of overeating I woke up the same weight as before, I ended up overeating the next day also and even got a stomach ache on both day, quite a bad one at that (I'm a degenerate I know). I didn't weight myself the next day cause I'd have felt shitty. Let 1 day go by and weighed myself this morning and I am 0.5lbs lighter than before this whole binge episode?

Also the improved insulin sensitivity I have noticed from the 10mg dose onward has been amazing. I'm exited to go up to 15mg next week, to see if these benefits of better nutrient partitioning and metabolic health keep increasing.

I've been at 10mg for a while and was debating if I should add Cagrilintide or up Tirzepatide to 15mg. Cagrilintide was looking very attractive to me but after taking note of these benefits from the Tirz (outside of the appetite suppression) I have decided to just up it
Click to expand...
No, I've been tracking calories for almost 2 decades now. There is absolutely nothing about tirz or sema that changed my BMR or p-ratio.
 
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How fragile is Tirzepatide? I was reconstituting a vial and since I'm puttin in 3ml I used a 5ml siryinge instead of using 3insulin siryinges so it'd be faster. But I wasn't quick enough to hold the plunger back and it shot the water in the vial really goddamn fast. did I damage the peptide?
 
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Luke391 said:
How fragile is Tirzepatide? I was reconstituting a vial and since I'm puttin in 3ml I used a 5ml siryinge instead of using 3insulin siryinges so it'd be faster. But I wasn't quick enough to hold the plunger back and it shot the water in the vial really goddamn fast. did I damage the peptide?
Click to expand...

No. No problem with Tirz.

The "fragility" issue is mainly one related to folded proteins like rHGH. Tirz isn't folded. It not the "physical force" that damages the molecule, it the creation of turbulence and bubbles.

Wherever there's a "water/air" interface, rHGH has a tendency to "unfold" exposing sticky parts of the molecule, which other rHGH monomers stick to, and eventually creates large inactive aggregates of rHGH.

High pressure water creates a huge amount of this water/air interface area, and at some point down the line, the longer the vial sits, the more aggregates form. Basically the turbulence reduces the stability of the rHGH, making it degrade into aggregates faster than would otherwise occur.
 
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Ghoul said:
No. No problem with Tirz.

The "fragility" issue is mainly one related to folded proteins like rHGH. Tirz isn't folded. It not the "physical force" that damages the molecule, it the creation of turbulence and bubbles.

Wherever there's a "water/air" interface, rHGH has a tendency to "unfold" exposing sticky parts of the molecule, which other rHGH monomers stick to, and eventually creates large inactive aggregates of rHGH.

High pressure water creates a huge amount of this water/air interface area, and at some point down the line, the longer the vial sits, the more aggregates form. Basically the turbulence reduces the stability of the rHGH, making it degrade into aggregates faster than would otherwise occur.
Click to expand...
Thank you very much.
A few days ago you told me that I shouldn't be getting a bubble with subQ, does that apply also if I am somewhat lower bodyfat? I use 13mm needles and put the whole needle in at a 45° angle but I still get the bubble, I can feel the tip of the needle touching the muscle underneat (since you feel that sort of deeper pricking sensation when you hit your abdomen muscle) but I still get a hard bubble
 
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Another question about moving from Tirz to Reta.

How do you know with Reta when you are at the right dose? With Tirz I get the appetite suppression, upset stomach if I over eat, and quieting of food noise.

I tried reta once (didn't give it a chance) but when I got no appetite suppression I got impatient and went back to tirz.

I plan to start at 2mg, and feedback on expected feelz?
 
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Luke391 said:
Thank you very much.
A few days ago you told me that I shouldn't be getting a bubble with subQ, does that apply also if I am somewhat lower bodyfat? I use 13mm needles and put the whole needle in at a 45° angle but I still get the bubble, I can feel the tip of the needle touching the muscle underneat (since you feel that sort of deeper pricking sensation when you hit your abdomen muscle) but I still get a hard bubble
Click to expand...

If it's .8ml or below you shouldn't be getting. a bubble.

Can you pick skin on lower belly to a "peak" and insert needle into top of that "peak" you crease (making artificial depth in essence).
 
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