Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[phenominal34]

How much Reta have you guys pinned at once? Ill be leaving dor 10 days and im thinking of doing that time period dosage before leaving, do you reckon 10-12mg at once is too much?

Depends on what your dose is currently at now ?

 

[Luke391]

How much Reta have you guys pinned at once? Ill be leaving dor 10 days and im thinking of doing that time period dosage before leaving, do you reckon 10-12mg at once is too much?

just do your regular dose and skip one week. it'll be fine. if you're worried about hunger/insulin sensitivity bring some phsyllium husk powder and berberine with you and take a ton of that. Or if you're gonna go out to eat maybe a little Acarbose with the big meals.

 

[Ghoul]

How much Reta have you guys pinned at once? Ill be leaving dor 10 days and im thinking of doing that time period dosage before leaving, do you reckon 10-12mg at once is too much?

Depends on what dose you're on now, 12mg is the max used in the trials, but I would not recommend jumping the dose up really high from where you currently on then traveling. You could end up regretting your decision. Maybe if you're at 8mg now....

 

[SmallTitsIRL]

I'm at 1mg daily reta + 1mg cagri weekly (just enough to not binge and not think much about food), I was thinking pinning the dose I'll be missing out, in this case 10mg. I'm well aware that very likely the first couple of days will be unbearable. Would definitely be a nice experiment

 

[Luke391]

I'm at 1mg daily reta + 1mg cagri weekly (just enough to not binge and not think much about food), I was thinking pinning the dose I'll be missing out, in this case 10mg. I'm well aware that very likely the first couple of days will be unbearable. Would definitely be a nice experiment

maybe load up 1syringe with 7mg (since you're doing 1mg a day) and bring it with you in a freezer bag with some ice. And do your weekly dose all at once, like most do

 

[phenominal34]

I'm at 1mg daily reta + 1mg cagri weekly (just enough to not binge and not think much about food), I was thinking pinning the dose I'll be missing out, in this case 10mg. I'm well aware that very likely the first couple of days will be unbearable. Would definitely be a nice experiment

Are you saying pin 10mgs ???? lol absolutely not !!!

 

[bananafeet]

Volume determines the pharmacokinetics, ie, how quickly the drug is absorbed, and therefore how quickly and high peak blood levels rise. Very small and very large volumes speed up absorption, and can make sides more intense than they otherwise would be.

.5ml is what Eli Lily uses for each dose.

I be learnin' some stuff here.

 

[Fat]

Volume determines the pharmacokinetics, ie, how quickly the drug is absorbed, and therefore how quickly and high peak blood levels rise. Very small and very large volumes speed up absorption, and can make sides more intense than they otherwise would be.

.5ml is what Eli Lily uses for each dose.

Super interesting.

Would that apply to TRT? like 100mg per ml vs 300mg per ml

 

[dinfar1337]

Super interesting.

Would that apply to TRT? like 100mg per ml vs 300mg per ml

subq? yes

im? not significantly if any relevance at all

still mostly determined by esterfication of the drug and not adminstration route.

 

[Luke391]

Hey could anyone direct me to a good video explaining Cagrilintide? I know it is an Amylin receptor agonist but still don't understand what amylin does and what other benefits/risks it provides outside appetite suppression

 

[Sparkles]

.5ml is what Eli Lily uses for each dose.

0.6ml per dose (all strengths) in the UK kwikpens.

 

[Ghoul]

0.6ml per dose (all strengths) in the UK kwikpens.

The extra .1ml per dose in the multi dose Kwikpens is to compensate for the dead space created by the mechanism and interchangeable needles.

The .5ml fixed dose pens are a sealed system that don't have the same dead space.

On another note, Wegovy (Sema) increases volume from .5 to .75ml for 1.7mg and 2.4mg to slow absorption of the two largest doses, presumably to lower peak blood concentration and reduce the intensity of sides.

 

[Sparkles]

The extra .1ml per dose in the multi dose Kwikpens is to compensate for the dead space created by the mechanism and interchangeable needles.

The .5ml fixed dose pens are a sealed system that don't have the same dead space.

On another note, Wegovy (Sema) increases volume from .5 to .75ml for 1.7mg and 2.4mg to slow absorption of the two largest doses, presumably to lower peak blood concentration and reduce the intensity of sides.

The dose is 60 units after priming, though, so surely the priming accounts for the dead space?
One of my "grievances" (for want of a better term) is that the kwikpen vial holds 3ml plus "a bit", so each kwikpen could deliver 5 doses, but EL restricted them to 4 doses. When I asked why, they replied that it was because they couldn't guarantee 5 full doses plus priming in every pen (I've never had one that didn't have more than enough to fulfil that - most having had at least 100 units remaining after using 4x 60 unit doses and having primed each time. Obviously, my data is from an exceptionally small number in the grand scheme of things).

 

[Ghoul]

The dose is 60 units after priming, though, so surely the priming accounts for the dead space?
One of my "grievances" (for want of a better term) is that the kwikpen vial holds 3ml plus "a bit", so each kwikpen could deliver 5 doses, but EL restricted them to 4 doses. When I asked why, they replied that it was because they couldn't guarantee 5 full doses plus priming in every pen (I've never had one that didn't have more than enough to fulfil that - most having had at least 100 units remaining after using 4x 60 unit doses and having primed each time. Obviously, my data is from an exceptionally small number in the grand scheme of things).

The instructions also point out a drop of medicine appearing on the tip is normal, which isn't the case with the fixed dose pens.



The bottom line is it's a sloppier mechanism with some waste in the process so a .6ml target probably has something to do with that.

The point is that some people using UGL make their dose .1m or .2ml which would have an effect on pharmacokinetics so isn't ideal.

 

[Liter O' Test]

below is my titration vs pharma titration
started at 1mg and my latest injection was 3.5mg, next will be 4mg.
only side effect was 1 night i ate too much and had a restless night of sleep.
i'll probably stay at 5mg and revaluate, need to figure out how much of my appetite I can trust.

 

[newguy2]

Can someone recommend the best way to transition from Tirz to Reta?

I've been on Tirz on and off for a few months. I'm currently at 5 mg split in two shots at 3 and 2mg.

I'm in a bulk right not but the glp helps me not go overboard with food.

I'd like the added benefit of Reta.

Should I just start at 2mg of Reta? I tried for a week splitting 2mg in two shots, it didn't seem to help much (I know appetite depression is not its strong suit) so I ended up going back to Tirz.

Also how long should I let the Tirz clear for first?

Thanks for any advice.

 

[Sera]

Can someone recommend the best way to transition from Tirz to Reta?

I've been on Tirz on and off for a few months. I'm currently at 5 mg split in two shots at 3 and 2mg.

I'm in a bulk right not but the glp helps me not go overboard with food.

I'd like the added benefit of Reta.

Should I just start at 2mg of Reta? I tried for a week splitting 2mg in two shots, it didn't seem to help much (I know appetite depression is not its strong suit) so I ended up going back to Tirz.

Also how long should I let the Tirz clear for first?

Thanks for any advice.

Don’t need to over complicate it, just stop taking the tirz and start taking the reta. It will take about 3-4 weeks to feel the full effect of the dose.

 

[newguy2]

Don’t need to over complicate it, just stop taking the tirz and start taking the reta. It will take about 3-4 weeks to feel the full effect of the dose.

Start at base dose of Reta and work back up?

 

[12o3j129dq]

I was finally able to obtain Cagrilintide. I will add it to my Sema. What is the initial dose? I have read something about 0.125 mg or 0.25 mg. What would you recommend?

 

[sushak]

I was finally able to obtain Cagrilintide. I will add it to my Sema. What is the initial dose? I have read something about 0.125 mg or 0.25 mg. What would you recommend?

0.125 mg messed me up for two days, felt terrible. I would recommend .06mg for your first shot to see how you react. I felt the bad effects the next day, absolutely 0 energy. This was qsc green top.