Yeah so I was going to stay out of this one entirely and believe me I'm not coming to the "noob's" (Dr Jim's words) but regardless of the respect that a lot of WKM's have for the Dr, there is clearly some obfuscation going on here. Some very good arguments were made here as to why the 10X rule may not be any more accurate than a supposed 5X rule and there has been NO EVIDENCE POSTED to the contrary other than a quote from Scally and a reference by Dr Jim to clinical studies which are proving to be as illusive as a pink unicorn. Instead, the usual ensues... A few supposed well respected members jump to the Dr's defense while simultaneously questioning the credibility of the poster. MESO is getting way to predictable now. I'm really disappointed about the devolution of this forum and the way members can't engage in legitimate dialog without being bashed. I'm fairly confident that this isn't what Millard had in mind when he created this forum. Very good points have been made here by guys on TRT and while these points may be inaccurate, Dr Jim has done nothing to prove that to be the case and has resorted to petty name calling. Sad.
The only "sad part" is people like you can't do their own damn homework to prove their own points like myself and Dr Scally have done on many occasions. Yea we are supposed to respond to any clowns beckoning call for proof, get a life MOOSE!
If you honestly believe there is no evidence to support the "ten times rule" (and then some) rest assured you are the one who will be running for the nearest exit
WHEN I CHOOSE TO post exactly that. Or they will concoct more BS to bolster their arguments such as "bloods" that don't exist, hearsay testimonials, third party observations, or their "gut" instinct, lol!
But what's really sad is some of you fools have now dug yourself into a proverbial pit of stupidity, completely ignoring the FACT a PEAK TT LEVEL will exceed the STEADY STATE NADIR by at least THREE to FOUR FOLD, thereby EASILY achieving the 10 fold increase I'm referring to.
(Moreover, I feel it's my obligation to allow these two the opportunity to "explain their position" regardless of how baseless it may seem, bc after all this is Meso, where completely transparent dialogue is the NORM, LOL!)
And the peak to steady state info is also available on GOOGLE Moose, yea so for a select few, ignorance is a way of life and all of my efforts to the contrary are in vain!
Finally why aren't you and these recent "do drop ins" locate evidence that supports their assertion a post-injection TT peak value of 5-6 is the norm! Because thats evidence does NOT EXIST, period!