What is the cause of loss of morning wood/libido?

[renmo]

Me: Male 40, 173 cm, 80 kg (~16% BF). Train 3–4×/wk (1h lifting + 1h cardio).
Meds: retatrutide 5 mg weekly, tadalafil 10 mg PRN.

Felt perfect on old protocol (Mon/Wed/Sat):

• Test ~90 mg each day (~270 mg/wk)
• Masteron prop ~40 mg each (~120 mg/wk)

Current protocol (last month, when problems started):

• Wed & Sat: Test 180 mg each (~360 mg/wk)
• Primo 20 mg each (~40 mg/wk)

image752×1109 149 KB


Symptoms: past month = morning wood gone, libido down.

Labs (drawn ~1 day after a shot):

• Total T: > lab upper limit
• Free T: > lab upper limit
• SHBG: 18.2 (low)
• Estradiol (E2): 72.3 pg/mL (ECLIA)
• Prolactin: 33.2 ng/mL (high)
• Hct/Hb: 51.9% / 17.6

Question:
What is the cause of loss of morning wood/libido?

 

[Ateam2023]

Me: Male 40, 173 cm, 80 kg (~16% BF). Train 3–4×/wk (1h lifting + 1h cardio).
Meds: retatrutide 5 mg weekly, tadalafil 10 mg PRN.

Felt perfect on old protocol (Mon/Wed/Sat):

• Test ~90 mg each day (~270 mg/wk)
• Masteron prop ~40 mg each (~120 mg/wk)

Current protocol (last month, when problems started):

• Wed & Sat: Test 180 mg each (~360 mg/wk)
• Primo 20 mg each (~40 mg/wk)

image752×1109 149 KB


Symptoms: past month = morning wood gone, libido down.

Labs (drawn ~1 day after a shot):

• Total T: > lab upper limit
• Free T: > lab upper limit
• SHBG: 18.2 (low)
• Estradiol (E2): 72.3 pg/mL (ECLIA)
• Prolactin: 33.2 ng/mL (high)
• Hct/Hb: 51.9% / 17.6

Question:
What is the cause of loss of morning wood/libido?

I'm going with Prolactin for $500 Bob!

 

[craigdt]

Prolactin be dat way

 

[Alaju]

another 500$ for Prolactin

 

[renmo]

I'm going with Prolactin for $500 Bob!

How can I bring it down?

 

[craigdt]

How can I bring it down?

P5p, maybe.

Cabergoline, but a rough medicine.

Pramipexole, maybe.

Someone else will come along with better input

 

[Ateam2023]

How can I bring it down?

i've heard people use Cabergoline or Raloxifene , and im sure theres some others people might chime in from past experiences, ive never had a prolactin issue before, but i keep Ralox in my box of "what ifs",

 

[Ateam2023]

P5p, maybe.

Cabergoline, but a rough medicine.

Pramipexole, maybe.

Someone else will come along with better input

i take P5p everyday just to reap its other amazing benefits it can provide,

 

[Alaju]

I'd say 0.5 caber twice/once a week and only for 2 weeks, because you are not on 19-nor

 

[craigdt]

i take P5p everyday just to reap its other amazing benefits it can provide,

Care to share with the class the other benefits?

I haven't done much research myself

 

[Alaju]

i take P5p everyday just to reap its other amazing benefits it can provide,

never had a prolactin issue but I remember reading somewhere that p5p stresses the liver a lot,

 

[renmo]

i take P5p everyday just to reap its other amazing benefits it can provide,

What daily p5p dosage do you take? I've read somewhere that taking it for prolonged time may cause toxication

 

[Alaju]

my guess is that p5p will not lower your "Prolactin: 33.2 ng/mL " alot

 

[Ateam2023]

Care to share with the class the other benefits?

I haven't done much research myself

better mood regulation, reduced irritability, improved cognitive function, supports blood sugar regulation, for instance it helps gluconeeogenesis and glycogen breakdown, thats just a few , it also can help females with pms issues by supporting "hormone-sensitive pathways". it's a good supplement , i take 100 mg daily, though the "recommended dose" can be 10-50 mg daily

 

[Ateam2023]

It also supports Glutathione production, Cysteine produced via P5p dependent pathway is a precursor for Glutathione, a major antioxidant, helpful in kidney tissue by preventing oxidative damage and inflammation that can contribute to CKD

 

[Ateam2023]

Heres what my robot says

 

[Ateam2023]

never had a prolactin issue but I remember reading somewhere that p5p stresses the liver a lot,

i would be curious to see that "reading" about liver stress and P5p , seeing how P5p active form of vitamin B6 , so it does not require conversion in the liver, plus the kidneys handle most of the elimination, NOT the liver.

 

[Ateam2023]

What daily p5p dosage do you take? I've read somewhere that taking it for prolonged time may cause toxication

Again i would be curious what you "Read" about this, Thank you

 

[Ateam2023]

EVERYONE who is reading this and that i would consider the source, theres to many kidney and liver information thats clinical and proven and legit, "i read somewhere if you do 100 mg testosterone a week you'll get BUFF" , see what i mean , its BS , alot of Research people , Know what your taking from 1st hand knowledge as well as supporting bloodwork, And read- Alot , to get an understanding, then apply it. i hope my little Rant made sense, Have a Grateful Day!

 

[ShutUpAndPump]

Estradiol double the ref range increases prolactin too.