Mr TP the Guinea Pig had hand numbness issues from Ngenla(somatrogon):
Code:
https://www.turkishpharmacysteroids.net/hgh-related/pfizer-ngenla-60mg
And he started to think about switching to Cinnatropin(he doesnt like genos)
Below is Cinnatropin:
Code:
https://www.turkishpharmacysteroids.net/hgh-related/cinnatropin-30iu
Mr TP the Guinea Pig had hand numbness issues from Ngenla (somatrogon).This also made him think that somatrogon may be stronger than somatropin, mg for mg. Below is chatgpt conversation he had. So mg for mg somatrogon seems stronger. And its cheaper and it needs 1 injection per week only. These issues make Somatrogon the most underrated product we have.
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ChatGPT Question:
I was using 42iu 14mg somatropin weekly, in 14 injections per week. Then I switched to somatrogon 45iu, 15mg per week. Somatrogon gave me more hand numbness. Does this mean somatrogon is stronger? What is the exact equivalent of somatropin-somatrogon? I am using nearly same mg but somatrogon causes more hand numbness so I had to quit.
ChatGPT:
Let’s break this down step-by-step so you can see why somatrogon might feel “stronger” than somatropin, even if the weekly milligram amount looks similar.
1. Somatropin vs. Somatrogon – what’s the difference?
| Feature | Somatropin | Somatrogon |
|---|
| Structure | Identical to natural human GH (191 amino acids) | Same 191-aa core, plus an extra C-terminal peptide linked to part of human chorionic gonadotropin (hCG) beta-subunit |
| Half-life | ~3–4 hours (needs daily injections) | ~30 hours (once weekly dosing possible) |
| Pharmacokinetics | Peaks quickly, falls within hours | Slower rise and sustained elevated GH levels for days |
| IGF-1 exposure | Peaks soon after injection, then drops | Prolonged IGF-1 elevation over the whole week |
Key point:
Somatrogon is not just "the same GH in slow-release form" — the chemical modification changes how long it stays active and how tissues are exposed to GH and IGF-1.
2. Why more side effects (like hand numbness)?
The hand numbness you felt is most likely carpal tunnel syndrome from GH-induced tissue fluid retention.
Even if the weekly milligrams look similar:
- Somatropin → big peak after injection, then a trough before the next dose.
- Somatrogon → fewer peaks/troughs, but GH stays elevated 24/7, so your total exposure (AUC) and average IGF-1 level over the week is higher.
This constant exposure can push IGF-1 into the upper physiological range for the whole week, leading to more fluid retention and nerve compression symptoms.
3. Exact dose equivalence?
Unfortunately, there isn’t a strict 1:1 mg conversion because:
- Bioactivity is measured in International Units (IU) for somatropin, but somatrogon’s labeling in mg is based on mass, not identical IU potency.
- In trials, once-weekly somatrogon 0.66 mg/kg produced similar mean IGF-1 levels as daily somatropin 0.24 mg/kg/week.
That means somatrogon milligram-for-milligram is more potent in terms of IGF-1 area under the curve.
If we use your numbers:
- Somatropin: 14 mg/week (≈ 42 IU/week) → 2 mg/day.
- Somatrogon: 15 mg/week → but because of its PK, IGF-1 exposure might be equivalent to ~16–18 mg/week of somatropin for many patients.
4. Implications for you
- Yes, your reaction suggests somatrogon was effectively “stronger” for you, at least in terms of side effects.
- The higher continuous IGF-1 might have pushed you into mild over-treatment territory, even if the mg looked matched.
- If you need HGH but want to avoid constant high IGF-1, daily somatropin gives more flexibility to adjust dose and avoid persistent side effects.
