MESO-Rx Exclusive Superdrol's unique characteristics

[MESO-Rx Administrator]

MESO-Rx is pleased to publish the eighth installment in the "Unique Characteristics of Anabolic-Androgenic Steroids" series by @Type-IIx . The article focuses on Superdrol:

Methasterone (Superdrol) is a potent anabolic steroid known for its impressive muscle-building properties and low androgenic effects. However, it is highly hepatotoxic, limiting its use to advanced bodybuilders during contest prep despite limited supporting data.

Methasterone Insights: Unique Characteristics of Anabolic-Androgenic Steroids – Part 8

Learn about Methasterone (Superdrol), a potent anabolic steroid with impressive muscle-building effects but significant hepatotoxicity risks.

thinksteroids.com

 

[Rush]

Curious to hear your view on the comparison between oral vs injectable administration? Are there any differences regarding effectiveness, hepatoxicity or anything else?

I felt that the injectable version felt easier on the system, but I would really like to hear your thoughts on this

 

[Type-IIx]

BOOM - Article dropped!!!

Superdrol is one that I think has a place, albeit a limited one, in the yearly plan. It is most potently antiestrogenic. Dry.

 

[Type-IIx]

Curious to hear your view on the comparison between oral vs injectable administration? Are there any differences regarding effectiveness, hepatoxicity or anything else?

I felt that the injectable version felt easier on the system, but I would really like to hear your thoughts on this

I think that injection is basically equivalent in hepatotoxicity to oral administration. The reason is simply that the angular 17α-methyl attachment increases potency [Superdrol is 17α-alkylated Masteron, so significantly more potent] and half-life to hours rather than seconds. Injectable, non-17α-alkylated AAS are rapidly metabolized by the liver, thus their liver concentrations are comparatively low.

Importantly, all androgens must be metabolized by the liver.

Similarly, I think that injection is basically equally efficacious or anabolic as oral ingestion for the same reasons – these drugs act systemically rather than locally after all.

On balance, it comes down to tolerability: whether Superdrol makes you nauseous when ingested or causes pain and swelling at the injection site with daily pinning. It's basically preference between these tolerability factors that decide.

 

[AlmightyAlpha]

I think that injection is basically equivalent in hepatotoxicity to oral administration. The reason is simply that the angular 17α-methyl attachment increases potency [Superdrol is 17α-alkylated Masteron, so significantly more potent] and half-life to hours rather than seconds. Injectable, non-17α-alkylated AAS are rapidly metabolized by the liver, thus their liver concentrations are comparatively low.

Importantly, all androgens must be metabolized by the liver.

Similarly, I think that injection is basically equally efficacious or anabolic as oral ingestion for the same reasons – these drugs act systemically rather than locally after all.

On balance, it comes down to tolerability: whether Superdrol makes you nauseous when ingested or causes pain and swelling at the injection site with daily pinning. It's basically preference between these tolerability factors that decide.

Any oral vs injectable passes the liver twice. Injectable superdrol is still considered toxic but it only passes the liver once

 

[Type-IIx]

Any oral vs injectable passes the liver twice. Injectable superdrol is still considered toxic but it only passes the liver once

First pass metabolism is practically irrelevant because of the hourslong half lives, low volume of distribution and extensive hepatic metabolism attributable to the 17a-methyl attachment. First pass is a “mere blip” for these drugs.

 

[AlmightyAlpha]

First pass metabolism is practically irrelevant because of the hourslong half lives, low volume of distribution and extensive hepatic metabolism attributable to the 17a-methyl attachment. First pass is a “mere blip” for these drugs.

That's why injectable is easier

 

[DaddyGoneBaddy]

Nice read. I love SDrol. 10mg 5 days a week pre workout has me pumped and jacked like no other oral 24/x7. That said I've only ever taken it blasting (500+ test plus 200+ primo/mast per week or more along with 2iu hgh 6 days a week) which obviously helps. I also take low dose extended release 500mg metformin every other night which probably doesn't hurt either (at least on possible insulin sensitivity part of sides). That may be why I'm a bit of an exception on SDrol in that it does not make me feel like shit like it does for so many. My cousin who is a major gear head can only run it for 3 weeks and he's beat. That said he runs 10mg morning 10mg night 7 days a week when he's using it. It's harsh on my lipids no doubt, but I use it at least 4 imes a year for 6 week runs and my levels always even out by month 2 of being off. I'd take it every day for life if I could.

 

[Jesintn]

Wondering what the degradation rate may be on ten to fifteen year old orals but now it doesn’t really matter bc around 2014 a company called lockout had it really inexpensive and I stocked up. I used it last competition in November, last five days before the competition day , and definitely worked. That’s all that really matters, that it worked

 

[xrayphoton13]

Wondering what the degradation rate may be on ten to fifteen year old orals but now it doesn’t really matter bc around 2014 a company called lockout had it really inexpensive and I stocked up. I used it last competition in November, last five days before the competition day , and definitely worked. That’s all that really matters, that it worked

It's pretty low. I would say they're fine

My vet actually told me about the shelf life extension program between the military and FDA. They tested meds and found full potency in many of them for 30-40 years even!

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1377417#:~:text=In%20conclusion%2C%20this%20study%20provides%20additional%20evidence,practices%20of%20drug%20expiration%20dating%20be%20reconsidered.

 

[AbsoluteKnight]

Idk I think one of the coolest things to me is that superdrol is basically just Methylated Masteron

 

[Type-IIx]

Nice read. I love SDrol. 10mg 5 days a week pre workout has me pumped and jacked like no other oral 24/x7. That said I've only ever taken it blasting (500+ test plus 200+ primo/mast per week or more along with 2iu hgh 6 days a week) which obviously helps. I also take low dose extended release 500mg metformin every other night which probably doesn't hurt either (at least on possible insulin sensitivity part of sides). That may be why I'm a bit of an exception on SDrol in that it does not make me feel like shit like it does for so many. My cousin who is a major gear head can only run it for 3 weeks and he's beat. That said he runs 10mg morning 10mg night 7 days a week when he's using it. It's harsh on my lipids no doubt, but I use it at least 4 imes a year for 6 week runs and my levels always even out by month 2 of being off. I'd take it every day for life if I could.

As relatively toxic as it is… and it is… we used to buy it in GNC and on bodybuilding.com. The latter got raided a year or so after they pulled Superdrol probably for continuing to sell it

 

[Jankauskas]

As relatively toxic as it is… and it is… we used to buy it in GNC and on bodybuilding.com. The latter got raided a year or so after they pulled Superdrol probably for continuing to sell it

Was the one they sold as pro hormone really the same compound?

 

[Anonymous member 154437]

Was the one they sold as pro hormone really the same compound?

Yes

 

[bigead]

Was the one they sold as pro hormone really the same compound?

Yes, they sold all kinds of designer steroids as pro hormones in the late 90s early 2000s, Madol, epi, thg, amongst a few. I miss madol

 

[Oswizzle]

I remember when Sledgehammer from Designer Supplements created it back on the Anabolicminds forums … the Superdrol/Phera-Plex combo !

 

[Ryu82]

I miss madol

Ow man, blast from the past. That stuff was fun times.

 

[Jankauskas]

Fuck man i took superdrol a couple times in the past (after the prohormone era), could never take it for more than 3 weeks even at 15 mg/day (tabs were 30mg) due to the sides.

I remember when I started lifting like 15 years ago some guys at the gym were taking it (prohormone), I don’t know how long they took it for but I imagine that it was longer than that, I don’t know how they could manage the fucking sides…

 

[xrayphoton13]

Was the one they sold as pro hormone really the same compound?

Yes. They even had M1T which is probably even more toxic. I don't know anyone who has used it in years

 

[Type-IIx]

Fuck man i took superdrol a couple times in the past (after the prohormone era), could never take it for more than 3 weeks even at 15 mg/day (tabs were 30mg) due to the sides.

I remember when I started lifting like 15 years ago some guys at the gym were taking it (prohormone), I don’t know how long they took it for but I imagine that it was longer than that, I don’t know how they could manage the fucking sides…

15 mg is excessive for 3 weeks!!!

It is potent stuff, alright. M1T as @xrayphoton13 refers to even more so, that was kind of like… really unnecessarily potent.

And I was just perfectly happy with Madol and Ultradrol at 5 mg a few days a week. All these (usable) drugs, I consider M1T unusable and Superdrol borderline-so, do have an optimal dose or maximally-tolerable dose that's usually 1/3 what people insist on dosing it at, I notice.