Stacking Retatrutide with Ozempic – Too Soon?

[pepe_]

Hey all—wanted to get some opinions or experiences here. I’ve been on Ozempic (semaglutide) for the past 5 weeks at 0.5 mg/week, and it’s going well so far in terms of appetite suppression and energy. I’m using it primarily for body recomposition alongside training.

I’ve been reading up on Retatrutide, and the potential looks serious—especially with its broader action (GIP/GLP-1/Glucagon). I was wondering:

• Is it worth stacking Retatrutide while still titrating up Ozempic?
• Or should I wait until I’m at the max effective dose of Ozempic (2.0 mg) before making any switch or stack?
• Should I switch to Retatrutide or see how effective this trial with Ozempic is?

From what I’ve gathered, Retatrutide is more effective. Not trying to rush anything, just trying to approach this intelligently. I know they hit some overlapping receptors but also have some distinct effects. Just don’t want to blunt the impact of either by doing too much too soon.

Appreciate any insight, especially if anyone here has actually run both.

 

[BP_6]

I would't recommend stacking GLP-1 type drugs. Pick one and stick with it. So switch to Ret, or stick with ozempic. But I wouldn't recommend doing both.

 

[dick_starbuck]

I stacked reta with tirz for a few weeks for shits and gigs. It actually went great. I think I was doing 3mg of each a week. Hunger was MUCH more suppressed. No negative side effects I noticed.

I probably wouldnt stack with sema unless it was cagrilinitide since we kinda know what that does.

 

[BigDadd7]

What is with this? Why not try upping your dose and being more active?

What's the best combo for losing weight while laying on the couch and eating donuts? Not trying to rush anything. Asking for a friend.

 

[juicebro]

I stacked reta with tirz for a few weeks for shits and gigs. It actually went great. I think I was doing 3mg of each a week. Hunger was MUCH more suppressed. No negative side effects I noticed.

I probably wouldnt stack with sema unless it was cagrilinitide since we kinda know what that does.

I tried stacking reta with cagri since I maxed out my reta dosage. Very effective but cagri fucked me up. Didn't want to get out of bed. Crazy lethargy so it wasn't worth it. Reta alone was never that effective in suppressing appetite but it also had no side effects.

 

[TRTSCOUT]

Just adding on here can anyone describe the science behind why no RETA glp stacks? I think it's likely in the papers and understanding that this is not wise... But it's a fair question...

I'm doing well on RETA... Down 15 lbs in two+ months and also up to 8mg per week. Do sense some hunger between shots (doing E3D splits rn).

Thanks for your time

 

[dick_starbuck]

Just adding on here can anyone describe the science behind why no RETA glp stacks? I think it's likely in the papers and understanding that this is not wise... But it's a fair question...

I'm doing well on RETA... Down 15 lbs in two+ months and also up to 8mg per week. Do sense some hunger between shots (doing E3D splits rn).

Thanks for your time

This is something Ghoul would be good for.

 

[AlexDavis43]

Just adding on here can anyone describe the science behind why no RETA glp stacks? I think it's likely in the papers and understanding that this is not wise... But it's a fair question...

I'm doing well on RETA... Down 15 lbs in two+ months and also up to 8mg per week. Do sense some hunger between shots (doing E3D splits rn).

Thanks for your time

Once weekly is normal injection frequency for sema and tirz. Some hunger before the next shot is normal and might be part of why these drugs work long-term. That hunger is clearly not enough to derail fat loss according to the clinical trials.

 

[zpped]

Just adding on here can anyone describe the science behind why no RETA glp stacks? I think it's likely in the papers and understanding that this is not wise... But it's a fair question...

I'm doing well on RETA... Down 15 lbs in two+ months and also up to 8mg per week. Do sense some hunger between shots (doing E3D splits rn).

Thanks for your time

Because they are competing for the same receptors.

Reta is a specific balance of 3 receptor agonists that was chosen among tons of other experiments of different ratios. If more glp1 activation worked better, they would have selected that ratio instead of the one they did.

 

[Rbvasques]

I like this picture from GLP-1 book by Lyle McDonalds.

Ive used all three, I didnt do well with Ozempic.
Tirz was great.
Reta was great.

Low Tirz (2.5mg) and Low Reta (4mg) was the best for me.

Now i only do 1mg reta Mon/Fri, for its benefits as I’m currently not cutting.

 

[brandyheard]

I would't recommend stacking GLP-1 type drugs. Pick one and stick with it. So switch to Ret, or stick with ozempic. But I wouldn't recommend doing both.

I agree, I personally stacked tirz and sema. It was awful I’ll never forget that. Felt like I was dying. It’s was so bad.

 

[phenominal34]

Nothing wrong with stacking. You felt like you were “dying” because your doses were to high. I’m stacking Reta 10mgs and Tirz 7.5 mgs rite now and feel amazing.

 

[sterlingschrute]

I like this picture from GLP-1 book by Lyle McDonalds.

Ive used all three, I didnt do well with Ozempic.
Tirz was great.
Reta was great.

Low Tirz (2.5mg) and Low Reta (4mg) was the best for me.

Now i only do 1mg reta Mon/Fri, for its benefits as I’m currently not cutting.

In your Reta experience (by itself, no stacking with the other GLPs), have you had any notable sides?

 

[Wkind]

Hey all—wanted to get some opinions or experiences here. I’ve been on Ozempic (semaglutide) for the past 5 weeks at 0.5 mg/week, and it’s going well so far in terms of appetite suppression and energy. I’m using it primarily for body recomposition alongside training.

I’ve been reading up on Retatrutide, and the potential looks serious—especially with its broader action (GIP/GLP-1/Glucagon). I was wondering:

• Is it worth stacking Retatrutide while still titrating up Ozempic?
• Or should I wait until I’m at the max effective dose of Ozempic (2.0 mg) before making any switch or stack?
• Should I switch to Retatrutide or see how effective this trial with Ozempic is?

From what I’ve gathered, Retatrutide is more effective. Not trying to rush anything, just trying to approach this intelligently. I know they hit some overlapping receptors but also have some distinct effects. Just don’t want to blunt the impact of either by doing too much too soon.

Appreciate any insight, especially if anyone here has actually run both.

Many do stack successfully. Reta with Tirz is common. You can do Reta with Cagri or even tesofensine for the further appetite suppression. I was stacking with tirz and I stitched to Cagri up to 1mg and teso 0.5 Ed and it worked great instead of tirz.

 

[Rbvasques]

In your Reta experience (by itself, no stacking with the other GLPs), have you had any notable sides?

None, likely because i came from Triz and Sema.

 

[HUGE McBIGLARGE]

I used to stack mt2 with pt141 and found it worked well, despite them both competing for the same receptors.

Motherfuckers will take a cocktail of anabolics that all compete for the same receptors but then say you shouldn’t stack reta with sema.

 

[jford25]

Hey all—wanted to get some opinions or experiences here. I’ve been on Ozempic (semaglutide) for the past 5 weeks at 0.5 mg/week, and it’s going well so far in terms of appetite suppression and energy. I’m using it primarily for body recomposition alongside training.

I’ve been reading up on Retatrutide, and the potential looks serious—especially with its broader action (GIP/GLP-1/Glucagon). I was wondering:

• Is it worth stacking Retatrutide while still titrating up Ozempic?
• Or should I wait until I’m at the max effective dose of Ozempic (2.0 mg) before making any switch or stack?
• Should I switch to Retatrutide or see how effective this trial with Ozempic is?

From what I’ve gathered, Retatrutide is more effective. Not trying to rush anything, just trying to approach this intelligently. I know they hit some overlapping receptors but also have some distinct effects. Just don’t want to blunt the impact of either by doing too much too soon.

Appreciate any insight, especially if anyone here has actually run both.

I personally stack Reta and Sema. I initially used Sema for six months, then took a six-month break, resumed Sema for two months, and then added Reta.

I’ve been on the combination of the two for six weeks now, and I haven’t experienced any issues. For many people, Sema may cause some side effects initially, but it’s important to gradually increase the dosage and follow other healthy habits like proper hydration and taking support supplements. With these precautions, you should be fine.

I’ve found that a weekly dosage of 0.5 mg Sema and 4 mg Reta is working well for me. I’m losing weight easily and haven’t experienced any side effects. I inject Reta on Wednesdays and Sema on Sundays.

I’m considering increasing my Reta dosage to 6 mg and maintaining at that level for more glucagon effects. I would also consider increasing my Sema dosage to 0.75 mg at some point if I stall out. Sema is effective for appetite suppression, while Reta does the heavy lifting. I’m not willing to try cargi because I know Sema is effective for appetite suppression and it’s very affordable and safe.

So I say go for it, keep your doses low to moderate and never increase dosage if you are still losing weight. Lowest effective dose is the name of the game.

Hey all—wanted to get some opinions or experiences here. I’ve been on Ozempic (semaglutide) for the past 5 weeks at 0.5 mg/week, and it’s going well so far in terms of appetite suppression and energy. I’m using it primarily for body recomposition alongside training.

I’ve been reading up on Retatrutide, and the potential looks serious—especially with its broader action (GIP/GLP-1/Glucagon). I was wondering:

• Is it worth stacking Retatrutide while still titrating up Ozempic?
• Or should I wait until I’m at the max effective dose of Ozempic (2.0 mg) before making any switch or stack?
• Should I switch to Retatrutide or see how effective this trial with Ozempic is?

From what I’ve gathered, Retatrutide is more effective. Not trying to rush anything, just trying to approach this intelligently. I know they hit some overlapping receptors but also have some distinct effects. Just don’t want to blunt the impact of either by doing too much too soon.

Appreciate any insight, especially if anyone here has actually run both.

I personally stack Reta and Sema. I initially used Sema for six months, then took a six-month break, resumed Sema for two months, and then added Reta.

I’ve been on the combination of the two for six weeks now, and I haven’t experienced any issues. For many people, Sema may cause some side effects initially, but it’s important to gradually increase the dosage and follow other healthy habits like proper hydration and taking support supplements. With these precautions, you should be fine.

I’ve found that a weekly dosage of 0.5 mg Sema and 4 mg Reta is working well for me. I’m losing weight easily and haven’t experienced any side effects. I inject Reta on Wednesdays and Sema on Sundays.

I’m considering increasing my Reta dosage to 6 mg and maintaining at that level for more glucagon effects. I would also consider increasing my Sema dosage to 0.75 mg at some point if I stall out. Sema is effective for appetite suppression, while Reta does the heavy lifting. I’m not willing to try cargi because I know Sema is effective for appetite suppression and it’s very affordable and safe.

So I say go for it, keep your doses low to moderate and never increase dosage if you are still losing weight. Lowest effective dose is the name of the game.