SSRI stack

[bananafeet]

Hey brain's trust.

Currently on Sertraline/Zoloft 50mg per day. Over two weeks in.

I know I can't take cabergoline or selegiline with this medication. Besides Modafinil what are other people staking with this stuff to help with the sides.

Primary issue is the sexual dysfunction (comes and goes) and the fatigue.

I wanna give this medication a solid 6 months to do it's magick. It's helping so far.

 

[Dr.V.P.C.]

It will probably subside after a while.
But you can try Bupropion to counter this sexless serotoninergic state.

 

[bananafeet]

It will probably subside after a while.
But you can try Bupropion to counter this sexless serotoninergic state.

Thanks mate. I'll wait it out for 6 months and then consider adding some of that.

 

[juicebro]

Primary issue is the sexual dysfunction (comes and goes) and the fatigue.

Sounds like Bupropion would be ideal for both issues like the other guy said. If you already have sexual dysfunction it's probably only gonna get worse with time.

 

[Zebedee]

Hey brain's trust.

Currently on Sertraline/Zoloft 50mg per day. Over two weeks in.

I know I can't take cabergoline or selegiline with this medication.

Why not? Genuine Q mate.

 

[craigdt]

It will probably subside after a while.
But you can try Bupropion to counter this sexless serotoninergic state.

Interesting, wondering if theres positive impact for users not on ssri?

 

[bananafeet]

Why not? Genuine Q mate.

I swear to God I found it as an interaction online. But now I can't find it!

 

[bananafeet]

Wikipedia:
Cabergoline has at times been used as an adjunct to SSRI antidepressants as there is some evidence that it counteracts certain side effects of those drugs, such as reduced libido and anorgasmia. It also has been suggested that it has a possible recreational use in reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession, and at least two scientific studies support those speculations.[10][11]: e28–e33 

Maybe I'm wrong. I think the risk I was worried about was serotonin syndrome

 

[Zebedee]

Wikipedia:
Cabergoline has at times been used as an adjunct to SSRI antidepressants as there is some evidence that it counteracts certain side effects of those drugs, such as reduced libido and anorgasmia. It also has been suggested that it has a possible recreational use in reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession, and at least two scientific studies support those speculations.[10][11]: e28–e33 

Maybe I'm wrong. I think the risk I was worried about was serotonin syndrome

Yeah I was aware of that & have never come across anyone mentioning a potential problematic interaction, hence why I asked. Personally I’d be more than happy trying caber to offset sexual sides from an SSRI because I think the forum reputation of negative health implications from caber is massively overblown - if you search my posts you’ll find a link to research showing (off the top of my head) guys talking something like 0.25mg ED for several years with zero negative effects.

Personally I think it’s an amazing med if you like a lot of sex.

As for serotonin syndrome - Yeah that’s, it’s worth keeping in mind that 50mg sertraline ED is a rather low dose that (in the UK at least) is generally a break-in dose to assess sides & is usually increased.

 

[bananafeet]

Yeah I was aware of that & have never come across anyone mentioning a potential problematic interaction, hence why I asked. Personally I’d be more than happy trying caber to offset sexual sides from an SSRI because I think the forum reputation of negative health implications from caber is massively overblown - if you search my posts you’ll find a link to research showing (off the top of my head) guys talking something like 0.25mg ED for several years with zero negative effects.

Personally I think it’s an amazing med if you like a lot of sex.

As for serotonin syndrome - Yeah that’s, it’s worth keeping in mind that 50mg sertraline ED is a rather low dose that (in the UK at least) is generally a break-in dose to assess sides & is usually increased.

hmm I'll consider it as a last ditch thing
Maybe after a few months.

I do love cabergoline but you've gotta make sure youre on-top of your impulsivity.

If anyone has any more details it would be good. I might try to search for some articles on Google scholar about the two used together.

 

[Zebedee]

hmm I'll consider it as a last ditch thing
Maybe after a few months.

I do love cabergoline but you've gotta make sure youre on-top of your impulsivity.

If anyone has any more details it would be good. I might try to search for some articles on Google scholar about the two used together.

I’ve not had a problem myself with impulsive behaviour / risk taking from caber use outside of with regards to sex, or at least not any I’ve ever noticed - but yes, it can be a huge issue for some, no doubt.

With regard to the sexual dysfunction, is it libido, ED, or struggling to orgasm, or a combination of them mate?

It might be worth experimenting with how & when you take your sertraline, ie trying 25mg x2 ED, taking it just before sleep etc. Yes, it has a much longer half life than the likes of venlafaxine, so some might argue that splitting the dose or changing when you take it won’t make much difference, but it won’t hurt to try.

 

[bananafeet]

I’ve not had a problem myself with impulsive behaviour / risk taking from caber use outside of with regards to sex, or at least not any I’ve ever noticed - but yes, it can be a huge issue for some, no doubt.

With regard to the sexual dysfunction, is it libido, ED, or struggling to orgasm, or a combination of them mate?

It might be worth experimenting with how & when you take your sertraline, ie trying 25mg x2 ED, taking it just before sleep etc. Yes, it has a much longer half life than the likes of venlafaxine, so some might argue that splitting the dose or changing when you take it won’t make much difference, but it won’t hurt to try.

I will consider split dosing. I found this:

Table 2 Summary table of pharmacotherapies for delayed orgasm or anorgasmia.

www.nature.com

Now I need to determine the actual risk of seratonin syndrome. Apparently Sertraline and higher doses can inhibit dopamine reuptake so I need to confirm that. Like you said 50mg is a starter dose.

 

[Dr.V.P.C.]

Interesting, wondering if theres positive impact for users not on ssri?

Probably yes . If you have acess to bupropion it def worth a try. (L tyrosine and/or mucuna pruriens can even make it more powerful , just avoid using it everyday)

 

[Seppuku]

Hey brain's trust.

Currently on Sertraline/Zoloft 50mg per day. Over two weeks in.

I know I can't take cabergoline or selegiline with this medication. Besides Modafinil what are other people staking with this stuff to help with the sides.

Primary issue is the sexual dysfunction (comes and goes) and the fatigue.

I wanna give this medication a solid 6 months to do it's magick. It's helping so far.

Cyproheptadine (Periactin) as needed has been used for ssri induced sexual dysfunction

Cyproheptadine treatment of sexual dysfunction induced by serotonin reuptake inhibitors - PubMed

Treatment of serotonin reuptake inhibitors (SRIs) is associated with sexual dysfunction. The cause of this dysfunction is unclear but may be related to stimulation of the serotonergic system. In the present article, we describe seven patients in whom iatrogenic sexual dysfunction induced by SRIs...

pubmed.ncbi.nlm.nih.gov

 

[k710]

Sounds like Bupropion would be ideal for both issues like the other guy said. If you already have sexual dysfunction it's probably only gonna get worse with time.

I used to take sertraline, wellbutrin (buproprion) was an almost instant add-on to my therapy. Im using fluoxetine now along with the bupropione. It also helps with adhd symptoms and has a bit of an energetic kick to it to counter-act the fatigue from ssri. I got prescribed adderall as well which I believe helped with the libido issues.

I was looking into cabergoline mainly as an emergency prolactin/gyno control if I was to ever need it. I was not aware it was used to treat sexual dysfunction. Ive been experiencing Anorgasmia for a while now.. waiting it out while im doing some cycle changes and bloodwork checks, but if it doesnt get better im going to have to take action. This shit sucks, especially if your libido is high

 

[bananafeet]

I used to take sertraline, wellbutrin (buproprion) was an almost instant add-on to my therapy. Im using fluoxetine now along with the bupropione. It also helps with adhd symptoms and has a bit of an energetic kick to it to counter-act the fatigue from ssri. I got prescribed adderall as well which I believe helped with the libido issues.

I was looking into cabergoline mainly as an emergency prolactin/gyno control if I was to ever need it. I was not aware it was used to treat sexual dysfunction. Ive been experiencing Anorgasmia for a while now.. waiting it out while im doing some cycle changes and bloodwork checks, but if it doesnt get better im going to have to take action. This shit sucks, especially if your libido is high

Pt141 allowed me to orgasm during sex and it was a good orgasm. But it only works on the day and you can't take it every day.

I'll ask my doc about buproprion. Be careful adding random shit when on these meds you can get seratonin syndrome. Cabergoline has a very long half-life.

 

[k710]

Pt141 allowed me to orgasm during sex and it was a good orgasm. But it only works on the day and you can't take it every day.

I'll ask my doc about buproprion. Be careful adding random shit when on these meds you can get seratonin syndrome. Cabergoline has a very long half-life.

Yeah I run everything through my Psych (except 200mg of test lol).
My coach is also very aware and takes them into account for my cycle/supplement regimes. Thankfully no signs of seratonin syndrome that I know of yet, but very much a concern.

I had no idea about the half life, I still got a lot of reading to do. Just know it will stop a leaky nip and lower prolactin levels.

 

[bananafeet]

Ok for other people finding this thread with similar issues.

I basically have zero side effects after adding 30mg Mirtazapine to my 100mg Sertraline. Moving dosing to night time helped with Sertraline day time fatigue.

Mirtazapine blocks certain seratonin receptors that Sertraline activates which cause undesirable side effects.

Mirtazapine has improved my sleep quality.

Edit:
What didn't work for me (reliably):
PT141
Cabergoline