Skin Rash/Hives from Reta

[SlamSumTest]

Started 2mg Reta 2 weeks ago. I noticed a few days after injection I woke up scratching my arms. I cleaned my bed sheets and my room but it continued to spread down my arm and armpits. And now my legs.

I’ve read it may be the reconstitution solution I bought (off Amazon) but threw it out, my Reta vial, and ordered a Hospiria BAC solution.

That said, I do feel like this may be the Reta and I definitely can’t tolerate the hives as I can’t sleep. I started taking Allegra about 2-3 days ago but it does look like it’s gotten slightly worse. No signs of fever, shortness of breaths, etc thankfully.

Would Tirz potentially have the same side effect? I would really hate to stop this all together as I’ve seen great results so far minus the allergic reaction.

 

[Faipdeooiad]

If you read through some of the posts on here for reta, a number of people have said similar - it seems to cause skin sensitivity in some people that manifests in different ways.

I’ve found it to be a trigger for my urticaria though it’s settled down now that I’ve been at 6mg for a few weeks.

 

[SlamSumTest]

If you read through some of the posts on here for reta, a number of people have said similar - it seems to cause skin sensitivity in some people that manifests in different ways.

I’ve found it to be a trigger for my urticaria though it’s settled down now that I’ve been at 6mg for a few weeks.

I see, I’m tossing mine and gonna try out Tirz. The good thing is 2mg of Reta obliterated my appetite, so I can probably get away with a smaller dose of tirz for my goals. Big bummer though because my energy on Reta was pretty decent considering I was underrating drastically

 

[Faipdeooiad]

I know you’ve mentioned Allegra but try some loratidine - others seem to be getting some joy from that

 

[SlamSumTest]

@Ghoul thoughts? You seem like a GLP1 expert here

 

[Ghoul]

@Ghoul thoughts? You seem like a GLP1 expert here

This happens with Tirz as well, but less frequently.

It's 7x more likely when antibodies are present.

I used to warn about protein drug immunogenicity and mostly lost interest, even though it's a MAJOR issue as far as drug developing scientists, pharma companies, and the FDA are concerned.

In brief, to minimize this potential immune response (which may end up becoming a long lasting, or even permanent problem once it occurs:

1. Stick to the pharma protocol. Especially once a week dosing. Don't use doses smaller than the smallest used in hype pharma protocol.
2. Don't use multiple GLPs
3. Don't mix peptides in the same vial/stringe.
4. Use as close to the pharma dilution rate (or greater) as possible.
5. Use pharma grade BAC (Hospira)
6. Filter
7. Don't stop and restart.

This is a major, complex topic

The potential issues from immunogenicity go far beyond skin sensitivity, and unlike that side effect, may not be detectable at all but much more serious.











Notice how much worse the immune reaction is to the two UGL/Compounded GLPs on the right of the chart, vs the pharma products in the left. Also, note the massive drop in immunogenicity when one of the non-pharma GLPs was filtered.

 

[anon55]

Never had any skin sensitivity on reta, up to 4mg a week. I don't know if it helps but I use desloratadine daily because my of steroid induced pruritus in my back.