Retatrutide + Cagrilintide

[mrvn5629]

Hello,
Does anyone here have experience with Retatrutide + Cagrilintide stacked together?
So far I’ve only been on Reta by itself. It’s been about 3–4 months since I last used Reta consistently — now I’ve only been taking it sporadically when my hunger got completely out of control. The highest dose I ever ran steadily was 6 mg weekly.
I just got my hands on both Reta and Cag and plan to start injecting tonight as extra support during my RFL diet. I’m also on 200 mg TRT per week.
Does this dosing schedule look reasonable to you?
I’m planning to start with 2 mg Retatrutide + 0.5 mg Cagrilintide and then increase every two weeks, following the progression in the picture.
Thanks...

 

[Ryobi]

send me all your unused cagri

 

[nixu]

Why do most people stack retatrutide with tirzepatide instead of retatrutide + semaglutide for appetite suppression?

Wouldn't reta + sema be better for appetite suppression than reta + tirz?

 

[xrayphoton13]

Like everyone else said above Cagri makes you feel like shit. Don’t want to do anything , some people are hyper responders, 1mg of cagri and 2mg of Reta and I don’t even want to go outside as soon as I get home from work.

Yup. I hated cagrilintide. I think in the future if I use retatrutide I'll add sema or tirz for more appetite suppression instead

 

[New2theGame!!]

Why do most people stack retatrutide with tirzepatide instead of retatrutide + semaglutide for appetite suppression?

Wouldn't reta + sema be better for appetite suppression than reta + tirz?

Because cag isn’t fighting for the same receptor like Reta and Tirz/Sema would be.

 

[any-name-you-wish]

I'm 7 months into my weightloss and 35kg down. I'm currently on 6mg reta and 0.4mg cagri, taken Tuesday (cagri)/Friday (reta). Started on prescription Tirz and used that for 4 months, got to 7.5mg there.

I took 0.5mg for the first dose of cagri and needed to have an afternoon nap. I took 0.25 for the next dose. I tolerate it pretty well now. Sometimes I think I get a little tired on shot day but it's not too bad.

 

[Svenderschreckliche]

Reta actually makes me hungrier and crave chocolate, etc. I also have some tirzepatide at home from my wife. Do you think it makes sense to try 5mg of reta and 1mg of tirzepatide, or should I start with 8-10mg of reta?
Thanks for your input.

 

[naps_for_gains]

Do you think it makes sense to try 5mg of reta and 1mg of tirzepatide, or should I start with 8-10mg of reta?

I've been running a combo tirz + reta for a while and have been happy with it. I titrate tirz to around where I want my appetite to sit then add in reta for the extra fat loss and health benefits. Currently at 3 mg tirz + 4 mg reta per week.

 

[Svenderschreckliche]

Thanks for the reply, maybe I'll start small with 1mg of Tirz. I wanted to order Cagri but I still have Tirz at home and will try it with Tirz first.

 

[SwampNut]

I have been going back and forth between tirz and reta, stacked mid-week with cagrilintide, for about six months. I was doing tirz or reta or stacking them experimentally for a little over a year before that. And tirz alone or with sema for another year before that. My primary goal is blood sugar control as a low level diabetic (just past pre-diabetes), but also some weight loss and hunger control. Food noise has been a lifelong challenge.

Retatrutide to me had the most side effects; gastrointestinal, fatigue, all of them. Cagrilintide has had the least. Really nothing. Tirzepatide gave me all the usual expected sides, but not as much as reta.

Being on cagri plus one of the others has the least fatigue, lowest gastrointestinal problems, and good blood sugar control. Unfortunately I'm a low responder to all of them so my dosage has to be high. I take max dose of reta/tirz alone, but when stacked with cagri, I do half of max of each. I split the dose by 3-4 days.

 

[Svenderschreckliche]

Tirz was very effective for me. At 7.5 mg, I had absolutely no appetite. That's why I stopped taking it, and later I simply wanted to try Reta because many people recommend it.

 

[dabolz]

I added 1mg Cag to 2mg Reta three days ago it kicked in today. Just drank a protein shake and it feels like I did nothing all day but eating.

2mg Reta solo still allow me to think about food and enjoy it.
1mg Cag solo suppress the feeling of being hungry but I keep eating out of boredom, frustration.

Reta solo awesome.
Cag solo not worth it.
The combination is insane.

 

[Jason_orange12]

I added 1mg Cag to 2mg Reta three days ago it kicked in today. Just drank a protein shake and it feels like I did nothing all day but eating.

2mg Reta solo still allow me to think about food and enjoy it.
1mg Cag solo suppress the feeling of being hungry but I keep eating out of boredom, frustration.

Reta solo awesome.
Cag solo not worth it.
The combination is insane.

Gonna try the combo soon reta alone actually makes me hungrier ( but leaner if i can not be a pig)

 

[assielima]

Lots of interesting responses in here.

For my own data point: I’ve been at 15 mg Reta for over a month and added 1 mg Cag two weeks ago. The main thing I’ve noticed with Cag is significant lethargy for a few days after pinning, which I don’t get with Reta alone. I’ve also noticed a drop in libido over the last week. Otherwise, I do note CAG seems to decrease my interest in food and increases my satiety, which has been relatively long gone with Reta.

Evenings have been pretty draining, so I’m leaning toward skipping Cag this week to see if those sides clear up. Reta by itself has always been very manageable for me, so I want to isolate whether Cag is the driver here. If removal of Cag helps, then I may see if a small dose of tirz helps with the appetite suppression without killing my energy (I've been on Tirz before and the low dosages didn't generally effect my energy much, but Tirz gave me pretty bad GI issues at higher titrations).

 

[Jason_orange12]

Lots of interesting responses in here.

For my own data point: I’ve been at 15 mg Reta for over a month and added 1 mg Cag two weeks ago. The main thing I’ve noticed with Cag is significant lethargy for a few days after pinning, which I don’t get with Reta alone. I’ve also noticed a drop in libido over the last week. Otherwise, I do note CAG seems to decrease my interest in food and increases my satiety, which has been relatively long gone with Reta.

Evenings have been pretty draining, so I’m leaning toward skipping Cag this week to see if those sides clear up. Reta by itself has always been very manageable for me, so I want to isolate whether Cag is the driver here. If removal of Cag helps, then I may see if a small dose of tirz helps with the appetite suppression without killing my energy (I've been on Tirz before and the low dosages didn't generally effect my energy much, but Tirz gave me pretty bad GI issues at higher titrations).

Did you hit a point of reta dose that even when you go higher it does nothing for supression?

Did you lose fat faster at higher dose? What does say 15mg bring over 8mg if no supression?

 

[assielima]

Did you hit a point of reta dose that even when you go higher it does nothing for supression?

Did you lose fat faster at higher dose? What does say 15mg bring over 8mg if no supression?

I increased following normal 4 week titration patterns. Food satiety and some food noise reduction continued into the first month or so on 12mg. But, then it began to fade. I had a similar experience with the earlier titrations, and thats why i continued increasing every 4 weeks. This could have also coincided with my increase in lifting consistency as I continued to lose weight. I have been relatively stagnant on the scale the last couple months and decided test increasing reta to 15mg to see if it changed anything, but it didn't seem to reduce appetite or bring back satiety. I'm still at 15mg because I am not having any sides and I want to get my next bloods to see if lipids or metabolic panels have changed.

I did not notice an increase in weight loss rate with higher titrations. If anything I noticed steeper decline early on and leveling out with higher titrations. I assume my body is one that acclimated quickly, so maybe I could taper down and then Kickstart again. But tbd.