Retatrutide + Cagrilintide

[mrvn5629]

Hello,
Does anyone here have experience with Retatrutide + Cagrilintide stacked together?
So far I’ve only been on Reta by itself. It’s been about 3–4 months since I last used Reta consistently — now I’ve only been taking it sporadically when my hunger got completely out of control. The highest dose I ever ran steadily was 6 mg weekly.
I just got my hands on both Reta and Cag and plan to start injecting tonight as extra support during my RFL diet. I’m also on 200 mg TRT per week.
Does this dosing schedule look reasonable to you?
I’m planning to start with 2 mg Retatrutide + 0.5 mg Cagrilintide and then increase every two weeks, following the progression in the picture.
Thanks...

 

[Wannabesamsulek]

You’re increasing the dose before the previous one has even had time to fully saturate. Retatrutide’s half-life is roughly a week, so it takes about 4–5 weeks per dose level to actually reach steady-state plasma levels.


Reta brings far more metabolic benefits than cagrilintide; cag is basically just an appetite suppressant. You’ll get better results by pushing reta as high as you can tolerate first and letting it handle most of the appetite control. Then bring in cag only once reta alone isn’t enough. That approach also lets you take full advantage of the added health benefits from its GIP-R and glucagon-R agonism.

 

[mrvn5629]

You’re increasing the dose before the previous one has even had time to fully saturate. Retatrutide’s half-life is roughly a week, so it takes about 4–5 weeks per dose level to actually reach steady-state plasma levels.


Reta brings far more metabolic benefits than cagrilintide; cag is basically just an appetite suppressant. You’ll get better results by pushing reta as high as you can tolerate first and letting it handle most of the appetite control. Then bring in cag only once reta alone isn’t enough. That approach also lets you take full advantage of the added health benefits from its GIP-R and glucagon-R agonism.

Thanks, I understand. So, I increase steadily to at least 8mg and see if I can go higher with the Reta or not. If I can't, I add Cagri? Do you have any tips for the PSMF/RFL? I was planning to do it with 900 calories. Doubt Reta will be enough, especially since I'm starting low and slowly again.

 

[Middus]

Thanks, I understand. So, I increase steadily to at least 8mg and see if I can go higher with the Reta or not. If I can't, I add Cagri? Do you have any tips for the PSMF/RFL? I was planning to do it with 900 calories. Doubt Reta will be enough, especially since I'm starting low and slowly again.

If you're struggling with Appetite, reta may not help that much. The odd thing is that for a few people, cagri is also weak regarding appetite suppression

 

[ChemBB]

You’ll get better results by pushing reta as high as you can tolerate first and letting it handle most of the appetite control.

10mg of Reta does nothing to my appetite, I'd be pounding half a kit of Reta a week to reduce my hunger any appreciable amount...

 

[juicebro]

Cagri is shit. Ive been on 15-20mg reta and it no longer does anything for my appetite. I just stay on 15mg a week now for the other benefits. I still have a kit of cagri in my fridge. It completely fucked me up so much that I even didn't want to leave the bed due to lethargy when I tried it. I might try a low dose semaglutide if I ever need more appetite suppression.

Definitely don't start with both together. Reta worked well in the beginning for appetite when you're increasing dosages every 2 weeks.

 

[mrvn5629]

Cagri is shit. Ive been on 15-20mg reta and it no longer does anything for my appetite. I just stay on 15mg a week now for the other benefits. I still have a kit of cagri in my fridge. It completely fucked me up so much that I even didn't want to leave the bed due to lethargy when I tried it. I might try a low dose semaglutide if I ever need more appetite suppression.

Definitely don't start with both together. Reta worked well in the beginning for appetite when you're increasing dosages every 2 weeks.

I see, thanks. How much Cagri did you start with? And did you combine it with Reta? I don't tank Sema well. I might try to add Tirz to my Reta, if Cagri ends up being shit...

 

[xrayphoton13]

Cagri is shit. Ive been on 15-20mg reta and it no longer does anything for my appetite. I just stay on 15mg a week now for the other benefits. I still have a kit of cagri in my fridge. It completely fucked me up so much that I even didn't want to leave the bed due to lethargy when I tried it. I might try a low dose semaglutide if I ever need more appetite suppression.

Definitely don't start with both together. Reta worked well in the beginning for appetite when you're increasing dosages every 2 weeks.

I also have two kits of cagrilintide I'll never use after using this first vial and a half to try out. I can't stand it. Makes me feel miserable. Yes I don't feel hungry but I don't feel like doing shit either. I didn't get any appetite suppression on reta so I started the cagrilintide. Titrated my way up to 1mg cagrilintide before I felt any appetite suppression but god I feel awful on it. It's like my mind has been hijacked. Very hard to describe. Headaches too.

I ended up back on tirzepatide. That's been the winner for me all this time.
If I needed appetite suppression on reta I would add semaglutide to it personally, not cagrilintide. Best way I can describe it is the glp-1 meds feel natural. Cagrilintide feels foreign and wrong.
Maybe OP will feel different with cagrilintide though. I've heard a lot of success stories with it

 

[Jaxino]

10mg of Reta does nothing to my appetite, I'd be pounding half a kit of Reta a week to reduce my hunger any appreciable amount...

The same happens to me too.... But maybe the Reta i am using is fake.

In any case I took 15mg today.... Hope it will reduce hunger.

 

[macmac]

I see, thanks. How much Cagri did you start with? And did you combine it with Reta? I don't tank Sema well. I might try to add Tirz to my Reta, if Cagri ends up being shit...

Cagri fatigue is real. Tried back to back days with 0,25 mg each day, super super fatigued. Then did 4 days 0,125 and after the 4th day the fatigue kicked in.

If you want the most appetite suppressing GLP tirzepatide is better in that case compared to reta. Seems like glucose control and (liver)fat burning is better with reta and food noise and inflammation is better with tirz.

I'm on 7mg tirz per week on a cut and didn't want to up the dose so chose to try the cagri i had in my freezer. Liked it for appetite control but beware of the fatigue and start as low as possible.