Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

I know I went on a lecture about how people are stupid for ignoring things they don’t want to hear that @Ghoul and @readalot bring up, but prions are pure nightmare fuel so you both are jerks for being on this forum and I’m ignoring you both. (Not really, but prions are nightmare fuel)
 
you both are jerks for being on this forum
I AM a jerk for being on this forum. You got me there.

I've made my piece with prions but don't use u-hCG anymore haha. Can't really say I am a fan of peptides. Maybe I am missing out. Will most likely try GH soon or stare at the $450 vial in the fridge for a while like I did with the stanozolol for a couple of years. I take my time.
 
I AM a jerk for being on this forum. You got me there.

I've made my piece with prions but don't use u-hCG anymore haha. Can't really say I am a fan of peptides. Maybe I am missing out. Will most likely try GH soon or stare at the $450 vial in the fridge for a while like I did with the stanozolol for a couple of years. I take my time.
I wish I could lay off the u-HCG. I've tried for many years to rid myself of obsessive thoughts about lady pee, but I always fail. I have finally found peace with my desires and come to accept who I am. If injecting lady pee quiets the demons, then so it shall be.
 
Most of the peptides (in this field) are far too small to be physically capable of forming prions. The peptides(well, mostly proteins) have to be certain size to achieve 'structural flexibility' to switch like that, must have the hydrophobic areas that could subsequently be exposed and be unstable enough that interaction with 'turned brethren' would overcome the barrier to enter a different state. But not too unstable otherwise it wouldn't pass to start with.

At least that's my amateur take on it.

I just enjoy learning about these.
It's insanely interesting field of study.

I hope my insatiable curiosity never comes off as disregarding the infinitely greater knowledge you have in this area.

As I understand it, only a subset of proteins can become infectious brain damaging prions. It requires several elements,

-----------

1. Must be able to cross the blood brain barrier.

2. They must be able to take on an amyloid configuration.

3. Have the ability to self replicate by acting as a "template" to modify existing natural cellular proteins.

----------

I'll use my favorite peptide, Semaglutide to illustrate.

GLP-1 has more research behind it. so I'll use it for reference. but the same charachteristics apply to close analogs like Sema.

----------
1. GLP-1 easily crosses the blood brain barrier.

2. GLP-1 forms amyloid fibrils as the result of simply being reconstituted in a solution with the wrong PH, unless Polysorbate 80(or similar) is included as an excipient!

IMG_0069.webp

IMG_0068.webp

"Protein or peptide aggregation into amyloid fibrils is a widespread phenomenon that plays a critical role not only in many neurodegenerative diseases but also in the stability of protein- and peptide-based biopharmaceuticals."


3. Whether GLP-1 fibrils can replicate, and what would make it happen, is unknown.

So we have 2 of the 3 factors constituting a potential prion disease present in UGL Sema, and the 3rd is an unknown.

It's been demonstrated that aggregates, including fibrils, can be significantly reduced, and their future development slowed, by filtering at .10um or larger. Unexpectedly, smaller pore sizes cause more fibrils to form.

No good can come from injecting amyloids into our bodies regardless whether they can replicate or not, especially if they can cross the blood brain barrier. So in my opinion, filtering the larger aggregates out of peptides will reduce the amount of that harmful gunk, and reduce the chances of some mutated form turning out to be something much worse years later.
 
Last edited:
@Qingdao Sigma Chemicals


Hey Tracy, it's been 3 weeks since my order was in customs (12/14/2024). Would i be getting a reship at 4 weeks? This sucks.


(Says "delivered to local carrier" since 12/19/2024 with zero movement)
Reship is 30 days after last tracking update. If it makes you feel any better my package that was stuck since 12/19 started moving a couple days ago.
 
That's my plan when I get my proviron raws, I plan on making some injectable proviron and running it for a week then running oral proviron for a week and see the difference.
i brewed some injectable proviron up a couple of years ago with results very similar to oral but at a way lower dosage 8mg injected felt like 100mg oral the problem was brewed at 15mg or 20mg it would constantly crash every day.
day 1 would be cloudy swirls and day 2 would be crystals so I had to reheat it every day to get it back into solution and then pin half a ml just to replace 1 pill twice a day. I got tired of that testing pretty fast. I do remember someone mentioning that they mixed up a transdermal proviron and that worked really well for them.

The reason i was testing is that the bioavailability of oral proviron is about 4% and injectable about 90% so I was hoping that 50 bucks of raws would last all year and could save a few bucks but the bullshit cost made the savings not worth it.
 
Hello,

Placed an order for Test E CA domestic on Oct 9th and confirmed shipping details on Oct 10th. Sent a follow up email about getting a tracking number on Oct 26th and followed up again on Nov 2nd. On Nov 3rd I was told test E is out of stock and there is an expedited shipment that will take 1-3 weeks. Sent another follow up on Dec 4 that got no reply. It's been 3 months since I've placed the order. If possible, could I get a refund?

Thanks
 
Hello,

Placed an order for Test E CA domestic on Oct 9th and confirmed shipping details on Oct 10th. Sent a follow up email about getting a tracking number on Oct 26th and followed up again on Nov 2nd. On Nov 3rd I was told test E is out of stock and there is an expedited shipment that will take 1-3 weeks. Sent another follow up on Dec 4 that got no reply. It's been 3 months since I've placed the order. If possible, could I get a refund?

Thanks
Ouch
 
Hello,

Placed an order for Test E CA domestic on Oct 9th and confirmed shipping details on Oct 10th. Sent a follow up email about getting a tracking number on Oct 26th and followed up again on Nov 2nd. On Nov 3rd I was told test E is out of stock and there is an expedited shipment that will take 1-3 weeks. Sent another follow up on Dec 4 that got no reply. It's been 3 months since I've placed the order. If possible, could I get a refund?

Thanks

@readalot
 
Back
Top