SpicyMeatball
Member
Turns you into a hot discord mom
MESO-Rx
Anabolic Steroids
Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic
- Thread starter Qingdao Sigma Chemicals
- Start date
Not really. That's why even Novo did the "step up" trials
I read 3 anecdotes so far. All women. The most common complaint was mild nausea anytime dose was raised to 7.2, constipation and hairloss. next was skin sensitivity when on 7.2 for a while..
Rippidy Dippidy
Member
It all made sense when you said "woman"
Rippidy Dippidy
Member
A female complaining about a drug holds as much weight as a polyester towel.
Jeffholio5
Member
I’m convinced most of these people on megadoses of glp1s are just too impatient to get results similar to a gastric bypass. I know not always true but starting doses of all of them murder my appetite.
Rippidy Dippidy
Member
Same. I titrated up to 1.5mg Sema a week to help my appetite on my diet and i was mildly nauseas 24/7. It made eating 2300 calories a breeze when i was cutting.
Jeffholio5
Member
I skipped sema went straight to tirz, never went over 2.5mg for months and couldn’t gain when I wanted on that dose. Dropped to 1mg and was able to have some appetite but still was hard to get enough calories. Super effective for cutting though. Messed with reta for a month started and stayed at 2mg/week and no appetite, nausea occasionally and gnarly reflux symptoms. Dropped that and off them all together now for 2 weeks and still low appetite so force feeding myself on a schedule to maintain my calories. But yeah I have no idea how folks get to those mega doses I’m miserable even at starter doses and don’t seem to build a tolerance.
Ghoul
Member
Why would you expect a hormone, and that's what GLP is, an energy homeostasis regulating hormone, to have the same impact on everyone?
It's not a diet pill.
Would you expect 200mg/week Test to have the same impact on someone who's 800 natural vs some hypogonadal guy at 300?
You don't need a GLP. You make enough. You're not insensitive to it. So even a small dose is having a major impact. The people on "megadoses" have a deficit of GLP, which is why they aren't puking their guts out all day on 10x the dose you take. That's the reason responses are all over the map. Hyper responders are the ones who need it the least.
Do you know how bariatric surgery induces weight loss? A smaller stomach pushes food into the intestine faster, Intestinal hypertrophy releases....wait for it...GLP. It reduces appetite of course, and often puts diabetes into remission.
Now that guys who struggle to put on weight are using GLPs to make cutting even easier, it makes the question of who the real lazy fucks in this scenario are a lot more interesting.
For all the crybabies without the "willpower" to eat enough on a bulk, read on. Despite not being able to muster the strength to just open their mouths, put the food in, and chew, there's hope for you weak willed pussies:
Avexitide
The cheat in a syringe your mother's wish they had when they couldn't get your scrawny assess to eat anything.
It's an anti-GLP.
It blocks GLP receptors.
The perfect antidote for the guys above who just can't manage to eat another bite without puking because their biology...er, I mean abundant "willpower" won't allow it.
It's intended for those who bariatric surgery was too successful. And now the abundance of naturally produced GLP is a problem, causing hypoglycemia. and even too low of an appetite.
Amylyx Pharmaceuticals Announces Pivotal Phase 3 LUCIDITY Trial Design for GLP-1 Receptor Antagonist (Avexitide) in Post-Bariatric Hypoglycemia
- Pivotal Phase 3 LUCIDITY trial will evaluate FDA-agreed upon primary outcome of reduction in hypoglycemia events and designed to align as closely as possible with previous Phase 2 trial designs - Amylyx expects first study participant dosed in LUCIDITY in Q1 2025 and topline results in 2026 -...
www.amylyx.com
It's time to let it go. You haven't been thin your entire life because you were born with some innate moral superiority. The 120 pound stringbean in dirty jeans at the gas station isn't skinny in a world of abundant food because he's overflowing with willpower and self control. He just has a high level of GLP. for whatever reason, just like you. And now we have a way to increase, and decrease that hormone at will.
Sorry, your natural state of low appetite doesn't make you special any more. You'll have to find another way to distinguish yourself.
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Rippidy Dippidy
Member
No one here was talking about having issues with bulking.Why would you expect a hormone, and that's what GLP is, an energy homeostasis regulating hormone, to have the same impact on everyone?
It's not a diet pill.
Would you expect 200mg/week Test to have the same impact on someone who's 800 natural vs some hypogonadal guy at 300?
You don't need a GLP. You make enough. You're not insensitive to it. So even a small dose is having a major impact. The people on "megadoses" have a deficit of GLP, which is why they aren't puking their guts out all day on 10x the dose you take. That's the reason responses are all over the map. Hyper responders are the ones who need it the least.
Do you know how bariatric surgery induces weight loss? A smaller stomach pushes food into the intestine faster, Intestinal hypertrophy releases....wait for it...GLP. It reduces appetite of course, and often puts diabetes into remission.
Now that guys who struggle to put on weight are using GLPs to make cutting even easier, it makes the question of who the real lazy fucks in this scenario are a lot more interesting.
For all the crybabies without the "willpower" to eat enough on a bulk, read on. Despite not being able to muster the strength to just open their mouths, put the food in, and chew, there's hope for you weak willed pussies:
View attachment 307090
Avexitide
The cheat in a syringe your mother's wish they had when they couldn't get your scrawny assess to eat anything.
It's an anti-GLP.
It blocks GLP receptors.
The perfect antidote for the guys above who just can't manage to eat another bite without puking because their biology...er, I mean abundant "willpower" won't allow it.
It's intended for those who bariatric surgery was too successful. And now the abundance of naturally produced GLP is a problem, causing hypoglycemia. and even too low of an appetite.
Amylyx Pharmaceuticals Announces Pivotal Phase 3 LUCIDITY Trial Design for GLP-1 Receptor Antagonist (Avexitide) in Post-Bariatric Hypoglycemia
- Pivotal Phase 3 LUCIDITY trial will evaluate FDA-agreed upon primary outcome of reduction in hypoglycemia events and designed to align as closely as possible with previous Phase 2 trial designs - Amylyx expects first study participant dosed in LUCIDITY in Q1 2025 and topline results in 2026 -...
It's time to let it go. You haven't been thin your entire life because you were born with some innate moral superiority. The 120 pound stringbean in dirty jeans at the gas station isn't skinny in a world of abundant food because he's overflowing with willpower and self control. He just has a high level of GLP. for whatever reason, just like you. And now we have a way to increase, and decrease that hormone at will.
Sorry, your natural state of low appetite being won't make you special any more. You'll have to find another way to distinguish yourself.
Why are you posting random things from 2017-2020 referring to people who have problems with bulking when no one here even mention it?
Jeffholio5
Member
Despite the sass this was a super informative post and I appreciate it.Why would you expect a hormone, and that's what GLP is, an energy homeostasis regulating hormone, to have the same impact on everyone?
It's not a diet pill.
Would you expect 200mg/week Test to have the same impact on someone who's 800 natural vs some hypogonadal guy at 300?
You don't need a GLP. You make enough. You're not insensitive to it. So even a small dose is having a major impact. The people on "megadoses" have a deficit of GLP, which is why they aren't puking their guts out all day on 10x the dose you take. That's the reason responses are all over the map. Hyper responders are the ones who need it the least.
Do you know how bariatric surgery induces weight loss? A smaller stomach pushes food into the intestine faster, Intestinal hypertrophy releases....wait for it...GLP. It reduces appetite of course, and often puts diabetes into remission.
Now that guys who struggle to put on weight are using GLPs to make cutting even easier, it makes the question of who the real lazy fucks in this scenario are a lot more interesting.
For all the crybabies without the "willpower" to eat enough on a bulk, read on. Despite not being able to muster the strength to just open their mouths, put the food in, and chew, there's hope for you weak willed pussies:
View attachment 307092
View attachment 307090
Avexitide
The cheat in a syringe your mother's wish they had when they couldn't get your scrawny assess to eat anything.
It's an anti-GLP.
It blocks GLP receptors.
The perfect antidote for the guys above who just can't manage to eat another bite without puking because their biology...er, I mean abundant "willpower" won't allow it.
It's intended for those who bariatric surgery was too successful. And now the abundance of naturally produced GLP is a problem, causing hypoglycemia. and even too low of an appetite.
Amylyx Pharmaceuticals Announces Pivotal Phase 3 LUCIDITY Trial Design for GLP-1 Receptor Antagonist (Avexitide) in Post-Bariatric Hypoglycemia
- Pivotal Phase 3 LUCIDITY trial will evaluate FDA-agreed upon primary outcome of reduction in hypoglycemia events and designed to align as closely as possible with previous Phase 2 trial designs - Amylyx expects first study participant dosed in LUCIDITY in Q1 2025 and topline results in 2026 -...
It's time to let it go. You haven't been thin your entire life because you were born with some innate moral superiority. The 120 pound stringbean in dirty jeans at the gas station isn't skinny in a world of abundant food because he's overflowing with willpower and self control. He just has a high level of GLP. for whatever reason, just like you. And now we have a way to increase, and decrease that hormone at will.
Sorry, your natural state of low appetite doesn't make you special any more. You'll have to find another way to distinguish yourself.
Ghoul
Member
Trying to help you not feel so "sickened" by people using GLPs to lose weight.
Right? Those were your words?
A guy who pumps his ass full of premature death to sooth his muscle dysmophia sitting on his throne in judgement over others injecting GLPs to improve
their health.
That's what makes me sick. Knuckle dragging hypocrites without the slightest drop of self awareness.
Rippidy Dippidy
Member
If you actually read what i said, It's people who take these drugs while doing absolutely nothing in their lifestyle other then sticking themselves with a pen to lose weight is what makes me sick.
They'll stick themselves with a pen, sit on the couch and open a bag of Dorito's. I said that pretty damn clearly.
Then you went off on a tangent quoting guys from 2017 about how they have issues eating too much to simply get a point across that you know what another drug does with the reverse effect of a GLP agonist.
Which was simply plugged in to show that you have additional knowledge off topic for absolutely no reason other then to show you're "smart" to get some weird sense of validation from random strangers on the internet.
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On the contrary, the reports of side effects from women may seem more valuable in this case as they tend to have worse sides in regards to GLP.
Yeah bro, no one does that. It is very difficult to out eat glp-1s that is working.
You are simply forcing your experience on others. lol. Because 1mg of Sema knocks you out doesn't mean that is how it affects everyone, else they would not have stepped up to 2.4 in clinical trials. Now they've just wrapped up safety tests on 7.2mg.There must have been something they noticed that helped them to convince the FDA beyond: "some people eat their away out of treatment"
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Rippidy Dippidy
Member
You can 100% out eat a GLP agonist. Most the people that come to me for "info" on it their first question is roughly "can i eat whatever i want and still lose weight" because they don't actually want to put in any work. which again is what I'm sick of.
Zero will power to do anything for themselves other than making excuses why they're fat.
SpicyMeatball
Member
Is it that hard to comprehend that different bodies react differently and therefore need different dosages to achieve similar effects?
I said out eat a GLP-1 that is 'working'
Again this is all about your mindset and ideology. It is quite normally human to want to eat your cake and have it. If DNP wasn't so toxic and forced people to eat a certain way, almost anyone would want to eat what they want and take DNP. What is the selling point of SLU and BAM?
Researchers try create exercise mimetics for obese 60-70 year olds too old to get in decent cardio and resistance, gym bros hop on it trying to simulate work-outs with less input.
Researchers look into mitochondrial uncouplers (shit like DNP) like BAM-15 for the same reasons, peeps too old and too fat to get the best gains out of exercise, body builders on a cut want to use it as an easy way out.
It's not unique to fat people. All human beings would literally and figuratively love to eat their cakes and still have it. Its human nature not fatso nature
Jeffholio5
Member
I just got schooled by @Ghoul but yeah I guess I was under the wrong impression about how much variety there is to peoples glp receptor responses. Tbf though I’m a former/pseudo current fatty so I assumed I’d fall into the category that would require more medication but I guess I’m just lucky I get the intended effect from it.
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