MESO-Rx Exclusive Ozempic and Mounjaro for bodybuilders - more than just weight loss drugs

[MESO-Rx Administrator]

@Type-IIx explains the benefits of GLP-1 and GIP agonists like Semaglutide and Tirzepatide, as true insulin sensitizing agents. how they are different from other weight loss drugs, and the benefits as partitioning agents for bodybuilders.

I'm sure you've read a lot about Ozempic, Wegovy, and Mounjaro for overweight sedentary people in the mainstream media but if you want to read about the use of these drug from a bodybuilding perspective, read on:

Semaglutide and Tirzepatide are More Than Just Weight Loss Drugs

Learn how GLP-1 and GIP agonists like Semaglutide and Tirzepatide enhance insulin sensitivity, preserve muscle mass and reduce fat stores.

thinksteroids.com

 

[Ghoul]

Magnesium pills?

Extended release low dose Melatonin?

Magnesium (glycinate) sure. A neurological support more than a "sleep aid", but certainly plays a role in helping calmness and natural sleep.

Melatonin not so much. Growing evidence against it and the fad for it has been fading over the years.

Taurine can help (usually, more rarely the opposite). Best taken early so it's energy metabolism effects are out of the way by the end of the day.

 

[ve79]

Magnesium pills?

Extended release low dose Melatonin?

I smoke a little weed at night and it helps me a ton

 

[Rkl]

Magnesium (glycinate) sure. A neurological support more than a "sleep aid", but certainly plays a role in helping calmness and natural sleep.

Melatonin not so much. Growing evidence against it and the fad for it has been fading over the years.

Taurine can help (usually, more rarely the opposite). Best taken early so it's energy metabolism effects are out of the way by the end of the day.

I've not seen any evidence against low dose melatonin. Would be curious what you're referring to.

 

[Ateam2023]

I've not seen any evidence against low dose melatonin. Would be curious what you're referring to.

i can tell you from my personal experience, that melatonin is a waste of time, and in fact had the exact opposite effect as intended on me, Crapppp! ,

 

[Rkl]

i can tell you from my personal experience, that melatonin is a waste of time, and in fact had the exact opposite effect as intended on me, Crapppp! ,

Did you try high dose or low? High is known to do such wonky things.

 

[Ateam2023]

Did you try high dose or low? High is known to do such wonky things.

tried them all unfortunately,,

 

[IronMonk]

I tried so much to help me fall asleep. My brain wouldn't shut off. Ambien, CBD, and DSIP did nothing. Unisom, selank, and extended release melatonin left me groggy the next day. Eventually I tried Alteril (a blend of L-tryptophan, valerian, and melatonin). I found that taking half a tablet (1/4 the recommended dose) an hour before bed was perfect for getting to sleep without feeling it the next morning. Once my sleep cycle was reset I no longer needed it. Some swear by epitalon for sleep, but I haven't tried it.

 

[GaRebelZ71]

Been running 7.5 zepbound since September it's helped a lot

 

[Banana Joe]

There have been quite a few anecdotal reports, but these are the first actual numbers I have seen from someone showing how much Retatrutide (presumably) cleaned up his blood work. Take it for what is worth, I know there is some controversy around every influencer:


View: https://www.youtube.com/watch?v=mF5FrbFgn2g

 

[Banana Joe]

I take the total lack of replies that there aren't many actual BB's using Reta?
It looks like a potentially interesting protective compound, but I fear its appetite suppressive effects even at 1mg a week.

 

[pulpfictioncookie]

As always I appreciate the articles.


I have been on Tirzepatide 7.5mg a week for some time. I re-added growth and on a low dose cycle. 200 test, 300 mast and am noticing some phenomenal size growth.

Mind sharing your caloric surplus/deficit? I am at 700 cals daily deficit (21.5% BF), and my weight is no longer decreasing since I started test (300mg/week). I'm at 5mg/wk Mounjaro.

 

[Ateam2023]

Mind sharing your caloric surplus/deficit? I am at 700 cals daily deficit (21.5% BF), and my weight is no longer decreasing since I started test (300mg/week). I'm at 5mg/wk Mounjaro.

increase energy output,, more cardio,, stay properly hydrated, electrolytes etc,,

 

[Spaceman Spiff]

Mind sharing your caloric surplus/deficit? I am at 700 cals daily deficit (21.5% BF), and my weight is no longer decreasing since I started test (300mg/week). I'm at 5mg/wk Mounjaro.

Increase the dose? How old are you?

 

[Ghoul]

Mind sharing your caloric surplus/deficit? I am at 700 cals daily deficit (21.5% BF), and my weight is no longer decreasing since I started test (300mg/week). I'm at 5mg/wk Mounjaro.

Assuming you're actually in that level of deficit, it's not possible to not lose weight. 1-2lbs a week.

That bodyfat and T dose could mean high aromatization and water retention offsetting weight loss temporarily. High e2 could easily add 5-10lbs of water.

May want to check your estrogen levels. Are you noticing e2 sides? Nipple sensitivity or stronger emotions?

It's not uncommon to drop significant water weight within a week or so of getting high estrogen under control.

 

[newlosand]

Thank you, sir.

Ketosis means elevated hepatic partial fatty acid oxidation which doesn't contribute as much quantitatively to total body fat oxidation as skeletal muscle [complete] fatty acid oxidation.

I think I agree but people in ketosis can be in positive energy balance and gain body fat (so fat loss is likely but not guaranteed).

 

[DAC654]

Thanks, Millard!

New article for the Meso readership!j In this article, I make the case for incretin drugs as (note: mild!) partitioning agents.

I do not intend to make the case that incretins are as potent as Clen (clenbuterol HCl) which is, per-mg, more potent than testosterone in its anabolic effects (and enhancement of muscle power & strength and sprint perofrmance) albeit subject to a rapid diminution in this effect with time (due to β₂AR tachyphylaxis or desensitization), and subject to a threshold or ceiling at which side effects outweight benefits.

I do not intend to make the case that incretin drugs can overcome severe energy deficits (i.e., kcal restriction) & protein deficiency to enhance recomp or cutting!

Sections:
1. Recomp vs. Partitioning, and the concept of the p-ratio explained, including explanations of insulin resistance vs. sensitivity and the importance of leptin and hormones
2. Incretins: GLP-1 & GIP agonists, and how they serve to enhance insulin sensitivity
4. Lipolytic agents: why drugs like clen & stimulants like ephedrine work for fat loss although they cause insulin resistance
5. Evidence that incretins enhance body composition by maintaining FFMI & skeletal muscle index & preferentially reduce fat stores, even in instances devoid of resistance training and controlled nutritional adherence to high protein ingestion & modest deficits (that you must practice for any substantial recomp effect)
6. Distinction between insulin resistance & hyperglycemia (common bodybuilding misunderstandings of IR)
7. How exogenous insulin (slin) worsens insulin sensitivity despite ameliorating hyperglycemia.

Great read !

 

[rxr260]

I'm considering switching from tirzepatide to Semaglutide (more cost effective).
Currently on 7.5mg of tirz, does anyone know the equivalent dosage of semaglutide ? I was considering starting on 0.5mg.

 

[BigDadd7]

I'm considering switching from tirzepatide to Semaglutide (more cost effective).
Currently on 7.5mg of tirz, does anyone know the equivalent dosage of semaglutide ? I was considering starting on 0.5mg.

Tirz is so cheap it's practically free

 

[rxr260]

Tirz is so cheap it's practically free

Is it ? Haha not compared to Semaglutide. Sema is a lot cheaper though.

In all honesty as well I ran sema a little bit in the past and I found the appetite suppression stronger.

 

[Ghoul]

I'm considering switching from tirzepatide to Semaglutide (more cost effective).
Currently on 7.5mg of tirz, does anyone know the equivalent dosage of semaglutide ? I was considering starting on 0.5mg.

Better too low than too high, though .75-1mg is a closer equivalent to 7.5mg tirz.