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[ackmack78]

Less chance of aggregates forming.

Would you be able to explain why? This is way out of my wheelhouse

 

[crispybacon!]

Would you be able to explain why? This is way out of my wheelhouse

Credit to @Ghoul who knows far more than most! The dumbed down version is that it gives the proteins more room and less chance for collision.

It’s most often protein aggregation. Aggregated rHGH is inactive.

Many things can cause it, but for UGL most likely it’s rHGH exposed to high temps (and / or oxygen) in storage or shipping loses structural stability, it unfolds, exposing previously protected “sticky” parts if the peptide chain, and become much more susceptible to clumping up with other rHGH molecules. Once these aggregates reach a certain size, they develop a kind of “gravity” that makes non-damaged folded rHGH molecules start sticking to the clump too.

Once it starts, the aggregate will continue to grow, with more and more molecules of rHGH attaching until it reaches a size based on the concentration of your solution. Only after tens of millions of rHGH monomers (single molecules of active rHGH) aggregate do they become large enough to become visible.

Aggregates form as soluble or insoluble. if they’re soluble, and you add more BAC, another ml or two, some or all of the rHGH will disassociate back into individual monomers and you’ll recover some of the rHGH from inactive back to active form.

View attachment 357553View attachment 357554

 

[desertchrome]

FWIW I just put 3mL in my 40s. No issues.

 

[Ghoul]

Sure but is doubling the volume going to fix whatever issues you're alluding to

Yes. It’s a widely understood principle in biopharma science that the greater the concentration of peptide / proteins, the higher the risk of aggregates forming.

They have to be enormous, tens of millions of rHGH clumped up into a (now inactive, useless ball) to become a single visible speck (100um+ in size). The vast majority are below visible range all the way down to the smallest aggregate, dimer (just 2 rHGH monomers attached). And everyone knows less dimer the better. Even if they don’t know what it is.

Pharma doesn’t exceed rHGH 15iu / ml concentration without adding extra ingredients that prevent aggregation, like poloxamer 188, which keeps the rHGH monomers separated, and with the correct formula allows rHGH concentrations up to 40iu/ml without losing rHGH to aggregation.

So my rule of thumb is to follow pharma’s lead by keeping concentration at or below (lower is better) 15iu/ml.

 

[thehogsters]

Opti's Reta is fucking fire. I lost 20lbs on 1.5 vials. The old lady cant wear one pair of her pants. She lost that much weight on three quarters of a vial.

 

[Nick925]

Opti's Reta is fucking fire. I lost 20lbs on 1.5 vials. The old lady cant wear one pair of her pants. She lost that much weight on three quarters of a vial.

I agree

 

[justanoob]

Does Opti offer a testing credit if I were to send out an item for testing?

 

[CHIEF M]

3 ml in gold tops to minimize aggregates. 2 ml might work but it’s suboptimal

I do 2ml I’ve been fine lol

 

[Flatriggerman]

Does Opti offer a testing credit if I were to send out an item for testing?

yes. shoot him an email.

 

[Flatriggerman]

Opti's Reta is fucking fire. I lost 20lbs on 1.5 vials. The old lady cant wear one pair of her pants. She lost that much weight on three quarters of a vial.

agree. switched from his Tirz to his reta. Tirz was kicking my ass. His HGH and Reta are a potent combo along with TRT.

 

[BuffMaltese]

I received my “finished processing order” email on Nov 5. What’s the typical turnaround time? I’m realizing I may run out of Reta and might need to place a quick order from a faster, but more expensive, source.

 

[Flatriggerman]

I received my “finished processing order” email on Nov 5. What’s the typical turnaround time? I’m realizing I may run out of Reta and might need to place a quick order from a faster, but more expensive, source.

under 2 weeks. Avg 8-9 days for me.

 

[Sagnastymuscle]

I received my “finished processing order” email on Nov 5. What’s the typical turnaround time? I’m realizing I may run out of Reta and might need to place a quick order from a faster, but more expensive, source.

If you run out it’s not the end of the world, stick with the product that works and give your body that time to reset then when you get your order you’ll theoretically be more sensitive to the dose you left off on, meaning you can get away with using less for a period of time.

 

[Jonboy]

agree. switched from his Tirz to his reta. Tirz was kicking my ass. His HGH and Reta are a potent combo along with TRT.

I lost some weight on Reta. Care to educate me a little on using hgh with it. Does it make it work better?

 

[DinoBB76]

I received the new batch of Test E UNIQUE, the oil is quite thick (GSO), nothing difficult to inject, even with a G27 you can do it

 

[Ghoul]

I lost some weight on Reta. Care to educate me a little on using hgh with it. Does it make it work better?

When you’re in the GLP induced calorie deficit (or any calorie deficit), rHGH will change body composition by preferentially targeting visceral over other areas and preserving muscle. More relevant the older you are. Central adiposity, “dad gut”, accumulates as GH declines after 25.

It’s a commitment, at least 4 months to really see a benefit. If you stop using, and regain any weight at all, it’ll go right back into visceral fat first.

 

[RockyP]

When you’re in the GLP induced calorie deficit (or any calorie deficit), rHGH will change body composition by preferentially targeting visceral over other areas and preserving muscle. More relevant the older you are. Central adiposity, “dad gut”, accumulates as GH declines after 25.

It’s a commitment, at least 4 months to really see a benefit. If you stop using, and regain any weight at all, it’ll go right back into visceral fat first.

Can attest to this. Have been running 4 iu GH for about a year now along with low / moderate dose anabolics. Ran tirz for 3 months and then switched to Reta for tolerability issues (mild). Since that time it did seem that most of the fat loss has come from the mid section. While I still have some fat on my glutes and lower back, my abs have been in for weeks at a bodyweight that I can’t recall ever seeing them in at least 20 years.

Any GLP / HGH is a great combo for the above reasons as well as the ability, if you were so inclined, to run higher doses of HGH while keeping fasting glucose in check. I also still run a high quality berberine supplement even on my GLP. I think there would still be a point where advanced users would still need to turn to insulin when running mega GH dosages but the GLP drugs move the goal posts on that quite a bit.

 

[Ghoul]

Can attest to this. Have been running 4 iu GH for about a year now along with low / moderate dose anabolics. Ran tirz for 3 months and then switched to Reta for tolerability issues (mild). Since that time it did seem that most of the fat loss has come from the mid section. While I still have some fat on my glutes and lower back, my abs have been in for weeks at a bodyweight that I can’t recall ever seeing them in at least 20 years.

Any GLP / HGH is a great combo for the above reasons as well as the ability, if you were so inclined, to run higher doses of HGH while keeping fasting glucose in check. I also still run a high quality berberine supplement even on my GLP. I think there would still be a point where advanced users would still need to turn to insulin when running mega GH dosages but the GLP drugs move the goal posts on that quite a bit.

TRT synergizes well with rHGH, since rHGH increases androgen receptors making Test work more effectively in muscle, and Test boosts GH receptors making it more effective.

 

[1Megaman]

I received my “finished processing order” email on Nov 5. What’s the typical turnaround time? I’m realizing I may run out of Reta and might need to place a quick order from a faster, but more expensive, source.

Just got an order a week ago and it took 8 days.

 

[Yonith]

I also still run a high quality berberine supplement even on my GLP.

Just curious why berberine as opposed to maybe Metformin?