MESO-Rx

Anabolic Steroids

Non-aromatising substitute for testosterone

SenorSuperdrol said:
Using mast as a serm or primo/EQ to control e2 is super common practice. More so for cycles your dose is pretty low.

Whatever works for you and keeps you feeling good and bloods dialed in long term is the best approach.
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Of course, we have to consider individuality factor in. Dhts are great tool but some still need an AI just quite a bit less.
 
lukiss96 said:
Of course, we have to consider individuality factor in. Dhts are great tool but some still need an AI just quite a bit less.
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Yeah bro, great point I agree.

With the current supply issues too, I think we’ll see more combo approaches DHT’s and AI’s. Since getting enough primo/mast to control e2 will be/is already hard for us in the states.
 
DugPrime said:
Go with a long ester, and daily injections. Also, find your sweet exemestane dosage, with two dose a day, on 500mg test, I'm currently taking 0.5mg twice a day (7mg a week), and I've never been more happy.
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On 45mg TE EoD and 200iu HCG EoD I needed 25mg of exemestane a day to get my e2 just barely in range.

I’ve never seen anyone be as resistant to AIs as me.
 
HUGE McBIGLARGE said:
On 45mg TE EoD and 200iu HCG EoD I needed 25mg of exemestane a day to get my e2 just barely in range.

I’ve never seen anyone be as resistant to AIs as me.
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If it makes you feel better, I am not far off.
And the doses that seem to work for a while, later on don't work.

I am working on dialing in my TRT now, and will experiment with some small blasts in the future if I manage to sort it out.
 
microdose your test with ed or e0d injections and ester wont matter. if anything the long esters would be more stable doing that
 
As EQ does aromatise, and aromatises differently to testosterone, the metabolites may differ. Perhaps more estriol, more estrone, or something else that is more unnatural. Either way, if the metabolites do significantly differ to those of testosterone, the estrogenic effects may differ too; perhaps affecting some estrogen receptor types more than others, with agnostic and antagonistic effects. All the while, it sheds doubt that serum e2 is an accurate representation of estrogenic activity.

That seems like a whole storm of variables which is harder to deal with than my current situation.

So far I’m still favouring mast/primo. While I understand that DHT derivatives exhibit some estrogen receptor antagonism, that is far more straightforward to deal with than guessing if EQ is anti or pro estrogenic.

lukiss96 said:
You sure your exemestane is not underdosed or something?
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The exemestane was UGL but reputable. The anastrozole was from a domestic pharma prescriber. Both were pretty similarly ineffective, so I’ve no reason to believe the exemestane was underdosed.


DugPrime said:
Switch to letrozole
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I’m getting my letro tested with Jano now. I’ll see how I get on with it, but if anastrozole and exemestane didn’t help much, I can’t imagine letro being any better. I’ll still try it though.
 
ripper908 said:
microdose your test with ed or e0d injections and ester wont matter. if anything the long esters would be more stable doing that
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That’s what I figured. I do my testosterone and HCG together every other day. When approaching a test I half the doses and do it daily to get the levels even more stable.
 
HUGE McBIGLARGE said:
On 45mg TE EoD and 200iu HCG EoD I needed 25mg of exemestane a day to get my e2 just barely in range.

I’ve never seen anyone be as resistant to AIs as me.
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The hcg makes controlling estrogen much harder. Your case is nothing unusual.

The people claiming 2x 25 mg exemestane per week is enough to control estrogen are wrong imo. Dosing everyday works much better.
 
ripper908 said:
why hcg? just curious
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Meant to be good for you with all the non-T hormones. I get it cheap. I like my balls. Don’t care about fertility as I’ve had a vasectomy.

I see no reason to not take it, other than it making my incredibly-hard-to-dial-in E2 slightly more incredibly hard to dial in.
 
Also how long have you been using Test?

I found it in the first and second year that even on 200-300mg/week when I was cruising, I had many issues including estrogen out of whack

Later on as more time passed by I needed less and less anastrozole to the point regardless of the dosage or the ester, I don't need much now.

So my theory is that body adapts over time and finds that balance that it seeks. It just gets used to synthetic Testosterone and AI and starts regulating something. Of course if it's been years for you using T and still not resolving then it's different story.

At least for me it happened to be the case. I remember I needed quite a lot of AI at first. Things changed on my 3rd or so year of this journey. I actually forgot I had issues too before since it was quite a lomg time ago now.
 
Very infrequent poster, but Ive had similar issues and will tell you how Ive fixed this for myself.

1. Use TE. Short esters cause more issues since they are hard to keep levels steady. TE is best. I also feel like faster test esters cause a little more hyper tension. Ime. TNE, for instance, I can almost immediately feel that pressure go up in my face and around my neck. At first I thought it was an allergic reaction.

2. This is the most important part. You gotta pin daily. I went from doing 2 pins/wk at 150mg with 1-1.5mg of Adex/week, to about 200mg TE with 1500HCG/wk with the very occassional Adex dose. HCG for fertility. E2 tested at 32.

3. Primo will definitely lower your E2. I was using 500TE/wk and my E2 came in over 200. Added 300 primo and it brought it down to normal range, BP was only slightly elevated there. 5/3 test/primo ratio has kept me AI free at every dose Ive tried. That 500T was my very first time using primo. Ive kept the same ratio basically for some time.

4. Mast will not lower E2, but it does act SERMish in that you may still have high E2, but wont get gyno or limp dick if the dose is right. Also seems to reduce the increased aldosterone effect that elevated test has, which is why its considered a 'dry' steroid. Ive not noticed Primo do this. Primo isnt 'dry', its just not as wet as test is, since it drops thr E2 water retention, but aldosterone also raises intramuscular water retention, which helps with strength and fullness.

Agree with the above comment about the body getting used to this stuff. Youll find your base dose and learn to go up from there.
 
HUGE McBIGLARGE said:
I’m getting my letro tested with Jano now. I’ll see how I get on with it, but if anastrozole and exemestane didn’t help much, I can’t imagine letro being any better. I’ll still try it though.
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Actually, letro is known to be very very strong, not suitable for most of us, but some peoples having bad results with exemestane/anastrozole (like you) must consider it.
 
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