I mean, end of the day, the only way to know if we're using too little BAC is to meticulously track our serum GH and IGF-1 levels over time, and if they fluctuate to the downside, then pull labs to see if we have developed antibodies to the rGH (worst case scenario). If the levels trend low over time, it could suggest aggregate formation (and those aggregates become clinically inactive), so we could infer we are losing active rGH to that. You'll definitely find lots of guys who use minimal water to recon and have no issues, but pharma does tend to go with 1 iu / 0.1 ml BAC, at least that's what my omnitrope was. However, Sero's are 0.5 - 1 ml with 5 to 6 mg (15 - 18 iu), so a bit more concentrated there. But there's significant differences in terms of the excipients uses in pharma grade GH / serostim vs generics, which would also impact the mixing ratios.