Nebivolol for lowering RHR

The difference in 80mg over 40mg Telmisartan is greater PPAR/insulin sensitivity benefits. The BP reduction at the higher dose isn’t much more than 40mg.

Correct I could've been more specific, and was referring specifically to BP control.

He doesn't want BP to go lower than where he's at now.
 
I also don't notice a difference in any sort of sides going from 5mg to 10mg. I run 5mg as a basal dose anytime i'm on gear as it keeps my blood pressure just under threshold, and RHR 60-65. However, like clockwork, if I use Tren or Anavar/Winstrol/Anadrol, that dose has to go to 10mg to stay at the same RHR and BP.

I've just added HGH in for the first time whilst on Tren and Anavar, and had to take an extra 2.5mg as it seems like 10mg isn't going to be enough to control the onslaught with HGH on top, which is known to raise RHR by itself anyway. I'll see how it goes as it may settle. I don't like to go above 10mg, but not because I'm concerned about selectiveness; I just see it as a sign to lower the androgen load because the need for more beta blocking is a proxy for pushing too much in terms of those particular CNS stimulating compounds.

That said, it's not like it becoming less selective >10mg will be a bad thing in my situation. I find less-selective beta blockers lower my HR better. The issue is usually memory problems (on propranolol for instance). It's still not going to be a blunt hammer >10mg in the way those earlier generation ones are though. Here are my notes on Nebivolol:

  • at doses ≤10 mg nebivolol preferentially blocks beta1-receptors.

  • Blocks both β1- and β2-adrenergic receptors in poor CYP2D6 metabolizers and at doses >10 mg.

  • Nebivolol, unlike other beta-blockers, also produces an endothelium-derived nitric oxide-dependent vasodilation resulting in a reduction of systemic vascular resistance.

  • Frequent administration (i.e., daily divided doses) unlikely to be more beneficial than once-daily administration.

OK so I tried different timings with Nebivolol and Anavar and have found what works to get my HR back to where it should be on the same dose of Nebivolol as before introducing the Var and HGH.

For anyone who's interested, here's what I was doing previously:

- 20mg Anavar dosed in the AM after waking.

- GH pre-workout and 2.5 hours before I plan to do the cardio for fat loss. Usually this was at the same time as the Anavar or a few hours after if the workout time had to slip.

- Full 10mg Nebivolol dosed post-workout, around 3pm, so approx 6hours after the prior two were taken. The logic being to limit the effect of it on a workout by having it almost 20 hours before the next one.

Clearly the timing of anavar and HGH was not helping due to it hitting as Nebivolol was getting to its lowest levels. I would also be falling asleep from fatigue due to anavar in the early afternoon. This is not related to HGH because I don't experience fatigue from it, and it was happening anytime I used Anavar or Winstrol AM like clockwork.

Here's what I do now:
- Anavar + Winstrol (so basically any orals) and HALF of my Nebivolol dosed just before bed (20mg Anavar, 25mg Winstrol, 5mg Nebivolol). The initial night combining these was to really try push things cardiac-wise, as both orals stimulate my HR. I also wanted to see if I could offset the fatigue they bring by just taking them at night.

- GH still the same, always AM with a few hours difference depending upon workout timing which doesn't vary too much. Same 5IU dose.

- Last 5mg of Nebivolol taken at usual time post-workout and around 3pm, for a total of 10mg Nebivolol.

Although the medical guidance suggests no benefit to splitting Nebivolol dose, there definitely is for PED purposes.

On the first day trying the orals and nebivolol at night, I had also dosed 100mg Tren E around 6pm, so that too was peaking overnight, as the Anavar and Winstrol was hitting. I expected a disaster. However, I slept like a baby, and the morning after, I woke and waited 10 mins to measure BP. It was 122/67 with a RHR of 71, when previously I had been reading 135/81+ consistently and HR up to 85.

Then, I did a 5IU HGH injection and went to the gym. Did not feel any negative effect of the previous night's nebivolol on the workout, and no HR increase from the HGH interferring which it has done previously. I also had what felt like a 'stronger' heart beat previously, which has gone. Especially during workouts which was getting annoying. So I'm pleased about that.

I'd also note - feeling no fatigue from the orals or sleepiness in the afternoon either. Looks like I've found what nails it for me, and splitting nebivolol and taking any problematic orals at night can indeed work wonders if it suits your body.

Hope this helps someone. @malfeasance
 
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Hi guys.

Just wanted to give some data points. Got Nebivolol last Saturday and have been taking it 5mg daily on top of 80 Telmisartan

Starting stats:
RHR 85
+1 day = 76
+2d = 70
+3d = 71

BP
138/70 starting
+1d = 136/71
+2d = 126/72
+3d = 121 /64


Cardio wise I’m just doing 30-60min fasted z2 cardio in the mornings to help w the cut.

Question for folks who’ve been faking Nabivolol for longer time:

should I expect further RHR reduction just from the drug itself or it’s pretty much tapped out here ?

Suppose the other ways are
1. Bump dose to 10mg but at that level it’s not cardio selective as 5mg. Would rather not cuz 5 is my rx dose

2. Change the gear stack. I’m coming off tren hex in about a month so I’ll see some improvement just from that.

3. More cardio at higher intensity? Doing z2 to help w a cut right now.

4. Running cardarine now for a couple of weeks already. Not sure if it helps w RHR. primarily running it to help w HDL (form DHT compouns use) and maintain endurance while using tren.
Not sure if cardarine helps w RHR metrics.


Hi guys. Just adding to my prior post. I think I’m a week into 5mg Nabivolol daily.

RHR down to 63.

BP 119/56.
 
Watch that diastolic. You don't want it to be below 60.
I'll run into a problem when running high deca/dbol where I have a high rhr and high systolic/low diastolic. Not sure how the hell to fix it so I inevitably end the cycle at that point. I've tried high magnesium and potassium and going easy on sodium, Nebivolol 5mg and telmisartan up to 20mg. Still end up with like 130/55 and rhr of 95, and I just don't think a spread that big can be good. My usual rhr is 60-70 and BP is 115/65
 
I'll run into a problem when running high deca/dbol where I have a high rhr and high systolic/low diastolic. Not sure how the hell to fix it so I inevitably end the cycle at that point. I've tried high magnesium and potassium and going easy on sodium, Nebivolol 5mg and telmisartan up to 20mg. Still end up with like 130/55 and rhr of 95, and I just don't think a spread that big can be good. My usual rhr is 60-70 and BP is 115/65
I should add calories were probably several thousand too high and sodium was probably higher than I thought it was.
 
I'll run into a problem when running high deca/dbol where I have a high rhr and high systolic/low diastolic. Not sure how the hell to fix it so I inevitably end the cycle at that point. I've tried high magnesium and potassium and going easy on sodium, Nebivolol 5mg and telmisartan up to 20mg. Still end up with like 130/55 and rhr of 95, and I just don't think a spread that big can be good. My usual rhr is 60-70 and BP is 115/65
Wise move to pull the plug. I’ve seen wide pulse pressures like that before too and it tells me I need to make a change. RHR of 95 is too much as well. It’s not very comfortable to feel your heart racing like that just sitting around.
 
My current BP protocol if I am blasting
80mg Telmiasartan "Currently though experimenting with 40mg Edarbi/ azilsartan"
12.5mg chlorthalidone
10mg nebivolo

Keeping my blood pressure low if I am cycling is especially important for me since I let it stay too high for many years so I have to error on the side of caution.
Do you use the chlorthalidone on cycle man?
 
I'm sure this has to do with my background as a competitive runner but I must admit I'd be much quicker to be worried about my RHR spiking than everyone else it seems.

Without nebivolol on a true TRT my RHR currently is around 49-50, back when I was competing it was 36-40. Now on 300mg test my RHR with 5mg nebivolol is right around 50, without it is around ~58-60.

Totally get I'm on the much lower side, but I wouldn't love the idea of my heart running at 80+ 24/7 year round.
 
I'll run into a problem when running high deca/dbol where I have a high rhr and high systolic/low diastolic. Not sure how the hell to fix it so I inevitably end the cycle at that point. I've tried high magnesium and potassium and going easy on sodium, Nebivolol 5mg and telmisartan up to 20mg. Still end up with like 130/55 and rhr of 95, and I just don't think a spread that big can be good. My usual rhr is 60-70 and BP is 115/65
One thing people do not note is automated cuffs can be notoriously far off on systolic when dealing with muscular people, usually raising it. If you do not have a stethoscope, it's worth it to get one just so you can hear when the actual blood flow starts (your systolic).

Note: This is not permission for all us assholes to say "oh well that's what I like to hear, I'm taking 15 off my systolic" - Please go verify this. But incredibly, incredibly common for those with muscular arms.
 
I'm sure this has to do with my background as a competitive runner but I must admit I'd be much quicker to be worried about my RHR spiking than everyone else it seems.

Without nebivolol on a true TRT my RHR currently is around 49-50, back when I was competing it was 36-40. Now on 300mg test my RHR with 5mg nebivolol is right around 50, without it is around ~58-60.

Totally get I'm on the much lower side, but I wouldn't love the idea of my heart running at 80+ 24/7 year round.
Hey man. Remember me from trying Ivabradine? I was able to get it working without major sides, other than minor vision related ones (FoV is brighter).

I was dosing it too frequently and that's what caused me issues. Now it's working wonders at 7.5mg per day. Has to be 12hrs apart.

I ordered the 10mg ones this time from PCT because I suspect they are SR which would be a big benefit imo. If not I'll split the tabs. It's very fast acting in me so SR would be a bonus.

Managing on just 5mg Nebivolol and 7.5mg twice daily of Iva now to keep HR low 70s/late 60s even on 10IU HGH. I'll be ramping gear back up soon past 200mg per week to see how HR responds.
 
I was dosing it too frequently and that's what caused me issues. Now it's working wonders at 7.5mg per day. Has to be 12hrs apart.
So glad to hear it’s working for you. I’ve been meaning to get some myself and now with the 20% sale it’s probably as good a time as any. I don’t have a real reason to toss it in right now but have always figured there’d be a time when dose or compounds could require a little extra lowering of the RHR!
 
Hey man. Remember me from trying Ivabradine? I was able to get it working without major sides, other than minor vision related ones (FoV is brighter).

I was dosing it too frequently and that's what caused me issues. Now it's working wonders at 7.5mg per day. Has to be 12hrs apart.

I ordered the 10mg ones this time from PCT because I suspect they are SR which would be a big benefit imo. If not I'll split the tabs. It's very fast acting in me so SR would be a bonus.

Managing on just 5mg Nebivolol and 7.5mg twice daily of Iva now to keep HR low 70s/late 60s even on 10IU HGH. I'll be ramping gear back up soon past 200mg per week to see how HR responds.

It will be my next try if RHR gets high again (i expect it soon as i'm going to add reta next week) since nebivolol lowered my already borderline low BP and made it impossible for me to use it. I've read ivabradine targets only rhr and this is what i truly need.
 
It will be my next try if RHR gets high again (i expect it soon as i'm going to add reta next week) since nebivolol lowered my already borderline low BP and made it impossible for me to use it. I've read ivabradine targets only rhr and this is what i truly need.
Yeah it does target only RHR - no residual BP effects which is also the reason I use it. I don't have BP issues on gear unless I get crazy, just RHR, so I have to find the balance and start with 5mg Nebivolol, 5mg Ivabradine and go from there.

If I need further support I'll up those doses or add Diltiazem at a low dose, 45-90mg. That affects BP hence the low dose, but the 3 in combination are like a hammer on HR but you have to be careful. Dilt not only lowers HR and BP directly but slows the metabolism of Iva to increase that effect too. So I only use that combo when it's heavy AAS load and things are balls to the wall and BP can take the reduction.

I haven't tried Iva alone because I benefit from the beta-blocker effects, but most of the HR reduction from the combo comes from the Iva anyway so I'm sure you'll find it useful.
 
Hi guys.

Wanted to follow up and ask anyone who’s run 5mg Nabivolol to lower RHR. Did you ever try running 2.5mg after a while ? Wondering if it still did the job on RHR AND also whether or not it’s worth running on cruises at 5mg or even 2.5 mg.

i run Telmisartan year round. During cruises or even TRT it’s to keep hematocrit in check but during cycles it’s part of the ancillaries for me.

Have you added nebivolol to your permanent stack or do you only run it during blasts ?
 
Hi guys.

Wanted to follow up and ask anyone who’s run 5mg Nabivolol to lower RHR. Did you ever try running 2.5mg after a while ? Wondering if it still did the job on RHR AND also whether or not it’s worth running on cruises at 5mg or even 2.5 mg.

i run Telmisartan year round. During cruises or even TRT it’s to keep hematocrit in check but during cycles it’s part of the ancillaries for me.

Have you added nebivolol to your permanent stack or do you only run it during blasts ?

How much has the telmi help lower ur hematocrit?
 
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