Nebivolol for lowering RHR

[BP_6]

From anecdotal experience, I have never seen neb affect clen personally on myself either way. At least at low doses of clen. Neb is much more b2 heart specific while clen is much more b2 bronchial specific. Sure there may be some effect as almost no receptor agonist is quite 100% specific, but at least for me I never noticed any loss in benefits of either drug.

 

[Deadpool99]

From anecdotal experience, I have never seen neb affect clen personally on myself either way. At least at low doses of clen. Neb is much more b2 heart specific while clen is much more b2 bronchial specific. Sure there may be some effect as almost no receptor agonist is quite 100% specific, but at least for me I never noticed any loss in benefits of either drug.

I guess I'll have to see how bad my rhr gets to determine if I'll use neb, I would like my TDEE to be increased as much as possible so I'll have to test the water before taking neb prematurely.
What do y'all consider the red/dangerous zone for RHR?
I remember I had someone who took 2mg Tesamorlein from one of the GLP1 forums and claimed that got him above 100 rhr and bro was on that for months and still debating weather to drop it. I'm just shocked and skeptical how tesa would do that.

 

[BP_6]

I guess I'll have to see how bad my rhr gets to determine if I'll use neb, I would like my TDEE to be increased as much as possible so I'll have to test the water before taking neb prematurely.
What do y'all consider the red/dangerous zone for RHR?

Neb is more for blood pressure than it is for RHR. I mean it does, but not as dramatically as people may think. Works amazing as the beta blocker with the least sides for a fitness person looking for blood pressure lowering. This lower side effects though comes at the cost of not being as effective as other beta blockers on RHR.

If RHR slowing is what you are looking for, there are much better beta blockers and non beta blocker compounds. I would only use Neb if blood pressure lowering is what you are trying to do personally.

 

[BamaCrazy]

I guess I'll have to see how bad my rhr gets to determine if I'll use neb, I would like my TDEE to be increased as much as possible so I'll have to test the water before taking neb prematurely.
What do y'all consider the red/dangerous zone for RHR?

Sustained HR above 100 (tachycardia). But personally I get concerned when it is above 80. I’d address it at 85-90.

 

[Ghoul]

I’m going to have to disagree with this.. It certainly mitigates much of the the RMR effects, but the B2 effects (and slight B3) are still driving a differential nutrient partitioning effect.

There’s a reason albuterol and clenbuterol still have a huge impact on asthma in those on selective beta blockers, because B2 is still fair game.

If this is in the planning stage, ivabradine will slow heart rate without any of the nebivolol b2 blocking spillover blunting clen at all.

Or, to maximize clen's effect, Celiprolol is an extremely selective B1 blocker from Japan, and instead of blocking actually agonizes B2, acting as an bronchodilator and enhancing fat burning!

It's not yet approved in the US, but you can buy from 911globalmeds without a prescription if it's not to "treat a medical condition, and for research/scholarly purposes only".

 

[Nidus]

If this is in the planning stage, ivabradine will slow heart rate without any of the nebivolol b2 blocking spillover blunting clen at all.

Or, to maximize clen's effect, Celiprolol is an extremely selective B1 blocker from Japan, and instead of blocking actually agonizes B2, acting as an bronchodilator and enhancing fat burning!

It's not yet approved in the US, but you can buy from 911globalmeds without a prescription if it's not to "treat a medical condition, and for research/scholarly purposes only".

You can also get Celiprolol in most of the EU pharmacies, germany alone has 3 generics of it

 

[KOArtist]

If RHR slowing is what you are looking for, there are much better beta blockers and non beta blocker compounds. I would only use Neb if blood pressure lowering is what you are trying to do personally.

Which beta blockers fit the bill on the RHR lowering?

 

[rexy]

Which beta blockers fit the bill on the RHR lowering?

Personally, I find the non-selective ones much more effective. I stick with propranolol. I tolerate it well.

There is a mechanism which backs this: the non-selective ones can cross the blood-brain barrier and have an influence on reducing adrenergic drive of the CNS through the brain as well as direct through the receptors on the heart.

As a result, they are better for HR loweing (and anxiety) but worse for athletic performance and other sides. Personally, I'm just a lifter, so I'm not bothered about potentially lower output and never experience any issues using propranolol for lifting. For me, the risk-reward is far in it's favour since it can drop me 20bpm or so vs. Nebivolol where i'm lucky to squeeze out 10bpm. Helping with anxiety is also a worthwhile trade-off for me.

I'm also not bothered about lower insulin sensitivity seeing as PEDs increase it and I'm on Sema year round.

I do sometimes swap to Neb if it's TRT time though.

 

[KOArtist]

What propranolol dosage does the trick for you?

 

[Photon]

Or, to maximize clen's effect, Celiprolol is an extremely selective B1 blocker from Japan, and instead of blocking actually agonizes B2, acting as an bronchodilator and enhancing fat burning!

It's not yet approved in the US, but you can buy from 911globalmeds without a prescription if it's not to "treat a medical condition, and for research/scholarly purposes only".

Cipla
Celiprolol 400mg $0.8 MSRP

But yea, I'd reckon it should be easy to get prescribed, it's just a beta blocker.

 

[rexy]

What propranolol dosage does the trick for you?

80mg sustained release.

 

[dcfreak]

I got prescribed Propranolol yesterday.

I cant believe I made this mistake but I actually hadn't even heard of the drug before...anyhow I took it in the AM with my clen and ECY before cardio and had a very unpleasant time.

0/10 recommend.

Looks like the Propranolol will be shelved until after the cut

 

[Sampei]

I got prescribed Propranolol yesterday.

I cant believe I made this mistake but I actually hadn't even heard of the drug before...anyhow I took it in the AM with my clen and ECY before cardio and had a very unpleasant time.

0/10 recommend.

Looks like the Propranolol will be shelved until after the cut

Bro it's used by surgeons/shooters for steady hands sometimes. It slows your heart rate like a lot. Not for doing cardio xD

 

[dcfreak]

Bro it's used by surgeons/shooters for steady hands sometimes. It slows your heart rate like a lot. Not for doing cardio xD

At the 30 min mark I felt like I was going hypo and was POURING cold sweat.

Only a block from gym so I made it home but not a good experience at all lol.

Felt like such a dumbass