How long does exo. GH suppress natural release?

[Wunderpus]

I'm trying to find info on how long an injection of exogenous GH will suppress my natural pulse. The reason I am asking is I am using peptides (GHRP & MOD GRF) in conjunction with my GH. I like to shoot my GH 2x a day, as I'm about to up it to 10iu. How does this look?

AM- 100mcgs of both GHRP and Mod GRF
+10 minutes minutes shoot 5iu GH
Lunch- 100mcgs of both GHRP and Mod GRF
Post workout- 100mcgs of both GHRP and Mod GRF
Pre bed- 100mcgs of both GHRP and Mod GRF
+10 minutes shoot 5iu GH

Obviously, this would be easier if I shot all 10iu of GH pre bed, however I've always found a slight benefit in splitting the dose when it's over 5iu.

 

[TrySepts]

Curious myself. Thanks for the question WP.

 

[Wunderpus]

Curious myself. Thanks for the question WP.

Yeah, no prob! I can only find info about how long to wait to pin GH post GHRP injection (10 minutes seems to be the consensus).

 

[Roco Bama]

The guy who got an igf reading of 511 by shooting 2ius of hgh was taking it before bed. You can see that it didn't suppress his natty gh but I believe it will over long period of time. The lab results from dudes on hgh that I came across indicates that taking more than 6ius yields 100ng per iu including baseline. For example, if your baseline level is 120, taking 7ius will yield 700ng of igf-1 meaning that natty gh is suppressed completely.

 

[mands]

I'm trying to find info on how long an injection of exogenous GH will suppress my natural pulse. The reason I am asking is I am using peptides (GHRP & MOD GRF) in conjunction with my GH. I like to shoot my GH 2x a day, as I'm about to up it to 10iu. How does this look?

AM- 100mcgs of both GHRP and Mod GRF
+10 minutes minutes shoot 5iu GH
Lunch- 100mcgs of both GHRP and Mod GRF
Post workout- 100mcgs of both GHRP and Mod GRF
Pre bed- 100mcgs of both GHRP and Mod GRF
+10 minutes shoot 5iu GH

Obviously, this would be easier if I shot all 10iu of GH pre bed, however I've always found a slight benefit in splitting the dose when it's over 5iu.

Do you worry about your natural test suppressing when running Testosterone?

Why worry about your natural gh suppression? In all reality your natural pulse will not do what you are wanting to do with exogenous GH.

mands

 

[Wunderpus]

Do you worry about your natural test suppressing when running Testosterone?

Why worry about your natural gh suppression? In all reality your natural pulse will not do what you are wanting to do with exogenous GH.

mands

I only am concerned due to the peptide usage. I don't want to use a GHRP if my pulse will be suppressed....

 

[Colt44]

Why worry about your natural gh suppression? In all reality your natural pulse will not do what you are wanting to do with exogenous GH.

I'd worry if there where no GH in the gland to dump. Waste of money

 

[mands]

I only am concerned due to the peptide usage. I don't want to use a GHRP if my pulse will be suppressed....

It will be suppressed from the GH usage anyways. You are thinking way too much into this big guy.

You're IGF-1 levels will be so elevated even if you were getting a natural pulse it would be most likely insignificant.

mands

 

[Wunderpus]

It will be suppressed from the GH usage anyways. You are thinking way too much into this big guy.

You're IGF-1 levels will be so elevated even if you were getting a natural pulse it would be most likely insignificant.

mands

If you have noticed 1 thing about me, it's that I try to perfect the entire process when possible, and get that extra 1% out of it.... I wonder if all GH pre bed, then day time use peptides?

 

[mands]

If you have noticed 1 thing about me, it's that I try to perfect the entire process when possible, and get that extra 1% out of it.... I wonder if all GH pre bed, then day time use peptides?

Yes I know how you are!! lol

I believe I've read and I would have to find it again that natural suppression is around the 24 hour mark or a little longer. I'm not 100% on this but I'm sure @Michael Scally MD or @Dr JIM might have a few studies.

mands

 

[Wunderpus]

Yes I know how you are!! lol

I believe I've read and I would have to find it again that natural suppression is around the 24 hour mark or a little longer. I'm not 100% on this but I'm sure @Michael Scally MD or @Dr JIM might have a few studies.

mands

Interesting. I wonder in what/if any way it changes with GHRPs and GHRHs? I know it's common to use them in conjunction with GH, however it seems to make the most sense to spread the GH administration as far apart as possible from the next GHRP/GHRH injection...?

 

[Perrin Aybara]

I don't know if I can find this info again, but if I do I'll link it. Anyway, it was something along the lines of that if you used peptides right before gh to enhance the gh that while your IGF-1 levels would be higher they would also return to baseline quicker more like with peptides rather than stay elevated longer like with gh alone. I don't know if that would affect suppression time though.

On the other hand supposedly peptides need your own natural levels to create a pulse and if you use them during times of low levels you don't get much out of them. So, it seems like if you were suppressed for that long after gh that peptides wouldn't work that well using them the same day?

 

[TrySepts]

Sheesh, little did I know that starting AAS would require me to become an amature endocrinologist! Lol

 

[Wunderpus]

Sheesh, little did I know that starting AAS would require me to become an amature endocrinologist! Lol

And if you're unlucky, an amateur surgeon.... :O

 

[Perrin Aybara]

Possibly an amateur phlebotomist, too.

 

[ackrug]

And an amateur proctologist

 

[Dr JIM]

Yes I know how you are!! lol

I believe I've read and I would have to find it again that natural suppression is around the 24 hour mark or a little longer. I'm not 100% on this but I'm sure @Michael Scally MD or @Dr JIM might have a few studies.

mands

I think your on SPOT there mate while the suppressive effect of GH is limited to a few days (from 1-3) the suppressive effect of IGF will persist considerably longer depending upon the GH dose, dosing interval and ones ability to manufacture and secret IGF.

The most reliable and useful data for comparative purposes in BB, is derived from FTT children who require high GH dosing similar to what pro BB use on a WEIGHT basis.

 

[Dr JIM]

Sheesh, little did I know that starting AAS would require me to become an amature endocrinologist! Lol

Kid yourself not this area of study or practice is very complicated and that's why sooooo many novice users develop sooooooo many complications, they PIN FIRST and ASK QUESTIONS LATER!

So keep thinking that way and read and read and read some more, then ask questions when conflicts (preferably those based on legit evidence rather than opinions, esp those derived from isolated anecdotes) occur.

 

[Wunderpus]

It's interesting to me, for sure. Jim, I imagine there isn't SHIT for studies on peptides, yeah? In your mind, is it either GH or peptides, not the two in conjunction (for sake of discussion, let's assume the peptides are legit)?

 

[Dr JIM]

I can't find any reason to use GH and PEP simultaneously as the intent would be some form of synergy much like it would be combining different AAS. But AAS exert their effects on the target organ (SKM) almost exclusively and that's one huge difference as there are several mechanisms and or pathways that may be influenced (at least theoretically) by combining AAS.

PEPs or secretagogues effect PITUITARY GH secretion and in doing so RAISE somatotropin levels which limit their benefit to physiologic GH levels or close to it.

It's for this reason I see no advantage of combining supplemental GH with PEPS. In fact I doubt PEPs have any utility when running GH bc their efficacy is likely markedly blunted by the HIGH somatropin AND IGF levels induced by exogenous GH

Wanna use PEPs perhaps the best interval is POST-CYCLE but there's ONE problem here also and that is GH IS SYNERGISTIC with TT and the low TT levels during the post-cycle interval should give one pause there also.

Yea the PEP studies are limited for several reasons namley the availability of FDA approved drugs used to raise GH. Research is EXPENSIVE and why would any Big Pharma company invest in research when another company already has one or two products on the market.