How do people lose control of estrogen more than 5 weeks into a test E/C blast?

[marsupial]

It's 5 half lives (i.e. roughly 4 weeks) for test E/C to be at steady state, and presumably shortly after that, test levels will also be relatively stable and unchanging aside from peaks/troughs within the supraphysiologic interval that the dose provides. Yet I've seen people say they lost control of estrogen symptoms on week 8 or something like that.

 

[psauce]

Consider the flip side of that question: are all the physiological responses to exogenous testosterone established by week five? Definitely not. Sex drive responds pretty quickly but things like mood, RBC, or bone density respond on timescales of several months to a year-plus. It follows that not all of the effects of testosterone are a simple function of immediate serum concentration.

More specifically to estrogen, aromatases in males have a number of tissue-specific properties, including expression regulation. That means there are several opportunities for phenotypic variation, so it’s reasonable for there to be a decent amount of individual variation.