High estrogen? Or decent ?

[HUGE McBIGLARGE]

Yeah, but why estradiol is ok to be 3+ times over the normal range and the rest of hormones like SHBG, prolactin, progesterone etc are not?

A “reference range” is just what’s normal for a “healthy” population. It doesn’t mean those values are the healthiest for you, especially if you’re on TRT.

Most of the studies showing high e2 as being dangerous in men show that it is predictive of poor health, but that doesn’t mean it is necessarily causative. If you’re natty and your e2 is high, something has gone wrong somewhere, and it may extend beyond just high e2.

Men with high estradiol levels have a low risk of cardiovascular disease - Nature Reviews Endocrinology

www.nature.com

“high estradiol levels were found to be associated with a low risk of cardiovascular disease”

Low endogenous estradiol levels are associated with elevated risk of cardiovascular disease mortality in young and middle-aged men in the United States - PubMed

In this study, low levels of E2 or FE2 were associated with elevated risk of CVD mortality.

pubmed.ncbi.nlm.nih.gov

“low levels of E2 or FE2 were associated with elevated risk of CVD mortality.”

Frontiers | Estrogen and Cardiovascular Health

The steroid hormone17β-oestradiol (E2), together with its receptors (ER), is thought to play a major role in the modulation of cardiovascular physiology and ...

www.frontiersin.org

“elevated E2 levels have been associated with an increased risk and incidence of cardiovascular disease in cisgender men”

Idk who to trust here. I’m scratching my balls, looking at my supraphysiological e2, and I can’t tell if this shit is my friend or foe.

For what it’s worth, here in the UK women are given estrogen-based birth control and HRT, and the docs never test their estradiol levels. Imagine being given testosterone pills, creams, gels, and pellets you shove up your dick and you literally never get your testosterone tested. Of course, that’s just women, but there are women out there with estradiol levels higher than any of ours and they’re doing fine.

 

[Ateam2023]

A “reference range” is just what’s normal for a “healthy” population. It doesn’t mean those values are the healthiest for you, especially if you’re on TRT.

Most of the studies showing high e2 as being dangerous in men show that it is predictive of poor health, but that doesn’t mean it is necessarily causative. If you’re natty and your e2 is high, something has gone wrong somewhere, and it may extend beyond just high e2.




Idk who to trust here. I’m scratching my balls, looking at my supraphysiological e2, and I can’t tell if this shit is my friend or foe.

For what it’s worth, here in the UK women are given estrogen-based birth control and HRT, and the docs never test their estradiol levels. Imagine being given testosterone pills, creams, gels, and pellets you shove up your dick and you literally never get your testosterone tested. Of course, that’s just women, but there are women out there with estradiol levels higher than any of ours and they’re doing fine.

comparing a womans estrogen levels to a man's estrogen level, is like comparing apples and oranges i would think, women are designed to have more estrogen than men "by design", Men aren't supposed to have elevated estrogen levels, hence the consequences of gyno etc,,,, The comfortable level of estrogen in men is vary , "user dependent " and for me personally, i want to keep mine in the acceptable range as to not cause "gyno" or hormonal acne that high estrogen "can cause" "can cause",,,,

 

[HUGE McBIGLARGE]

comparing a womans estrogen levels to a man's estrogen level, is like comparing apples and oranges i would think, women are designed to have more estrogen than men "by design”

But does that mean a man with high e2 will suffer more health consequences from his e2 than a woman with a similar e2? Other than symptoms of feminisation, of course

Men aren't supposed to have elevated estrogen levels, hence the consequences of gyno etc,,,,

Yeah, if you’re getting gyno that’s estrogen dominance, and you should get your estrogen lower not necessarily because it’s better for you, but because you don’t want boobs.

The comfortable level of estrogen in men is vary "user dependent " and for me personally, i want to keep mine in the acceptable range as to not cause "gyno" or hormonal acne that high estrogen "can cause" "can cause",,,,

yeah that’s what I’m saying. I’m not seeing much evidence to suggest what the healthiest e2 is. So I’m going based on where I feel best.

 

[Diesel77]

Just looked it up on google but little confused to understand . It explains testosterone to estradiol) ratio is generally considered to be between 10 and 20; meaning for every 1 unit of estradiol, you should have 10-20 units of testosterone, with the mid-range. My estrogen is at 96 with total testosterone of 1500

Do you have any symptoms such as mood, sensitive nipples or bloating? People react differently to different levels of estrogen. I get no sides under 80 so that's where I strive to be

 

[anon55]

Feel fine. Not on cycle right now. Only trt. Cyp 200. I dose only 40 units on Monday and 40 on Friday =160mg weekly. Subq/shallow IM. I switched from stomach subq injections and now using 1/2" slin pins in higher upper glute for subq.
This result shows high estrogen. I do have anastrozole for doc. I stopped using it 6 months ago when I lowered my standard cookie cutter dose of 200mg weekly to 160mg to avoid using AIs on trt. Should I lower my dose more or just take thr 1mg weekly anastrozole? Opinions welcome please.
I'm 5'10 160lbs. Not fat lol

Mine is 115pg/mL at 200mg a week. If you have no sides your e2 is great.

 

[Eddie.]

Mine is 115pg/mL at 200mg a week. If you have no sides your e2 is great.

115 for 200mg is definitely not great. Sides ain't the only factor of whether it's good or not

 

[anon55]

115 for 200mg is definitely not great. Sides ain't the only factor of whether it's good or not

I used finasteride. I cannot tolerate any aromatase inhibitor (mood problem)

 

[Ateam2023]

Mine is 115pg/mL at 200mg a week. If you have no sides your e2 is great.

side effects doesn't mean squat, some people have high e2 and have no symptoms, is having high e2 good? Absolutely not! Unless your trying to grow tits , keeping your e2 out of range isn't a "long game" winner,, Plenty of research backing up the problems associated with high e2 ,,

 

[Diesel77]

side effects doesn't mean squat, some people have high e2 and have no symptoms, is having high e2 good? Absolutely not! Unless your trying to grow tits , keeping your e2 out of range isn't a "long game" winner,, Plenty of research backing up the problems associated with high e2 ,,

Where do you prefer yours to be? I found primo keeps mine in check. I've been on 250testC 200 mast E . My e2 is close to 80. I was thinking about either adding in a little primo to bring it down or more Mast E. Thoughts ?

 

[Ateam2023]

Where do you prefer yours to be? I found primo keeps mine in check. I've been on 250testC 200 mast E . My e2 is close to 80. I was thinking about either adding in a little primo to bring it down or more Mast E. Thoughts ?

i like my e2 to be in the 40-50 range nothing more, its where my sweet spot is for maintaining erection quality, and general well being, my last e2 was 33 and i felt fine, although my libido/erection quality isn't like i want it at that low number,, And you have to remember that often times Mast won't affect your e2, it doesn't affect mine at all, i just recently started a little primo to my trt+ program and will be evaluating e2 through bloodwork,,

 

[Eddie.]

Where do you prefer yours to be? I found primo keeps mine in check. I've been on 250testC 200 mast E . My e2 is close to 80. I was thinking about either adding in a little primo to bring it down or more Mast E. Thoughts ?

More mast won't do anything. I have 67 on solo 250 test and the same with 200 mast on top. 50-100mg primo would work but why add a third injectable and not just take half aromasin a week?

 

[Diesel77]

More mast won't do anything. I have 67 on solo 250 test and the same with 200 mast on top. 50-100mg primo would work but why add a third injectable and not just take half aromasin a week?

That's an option too. I guess I've been trying not to use AI.

More mast won't do anything. I have 67 on solo 250 test and the same with 200 mast on top. 50-100mg primo would work but why add a third injectable and not just take half aromasin a week?

that is an option too. I guess I was just trying to avoid ai's. Ive got exemestane but never needed it because of the primo

 

[Eddie.]

I just got my e2 ultrasensitive test back and I am trying to figure out the reference range. The results give a reference range of less than or equal to 29 pg/ml. I am use to doing the regular test which has a higher reference range.

Mine came back at 20. Is this low? Is 20 on the ultra sensitive the same as 20 on the conventional test?

No it's not the same. You must go always with your reference range of the given test and lab, top of the range is 29 so i assume you're somewhere in the middle of the normal range. You could be fine with 25-30 as well but there's no reason to change anything if you feel ok.

 

[Grandpa]

No it's not the same. You must go always with your reference range of the given test and lab, top of the range is 29 so i assume you're somewhere in the middle of the normal range. You could be fine with 25-30 as well but there's no reason to change anything if you feel ok.

Thank you for your reply. I appreciate the info. I had deleted my post because I thought maybe I had asked a stupid question. I guess you replied at about the same time.

Been having joint issues that I wasn’t having before was thinking about changing primo from a 5/3 to 5/2 ratio.

 

[Ateam2023]

No it's not the same. You must go always with your reference range of the given test and lab, top of the range is 29 so i assume you're somewhere in the middle of the normal range. You could be fine with 25-30 as well but there's no reason to change anything if you feel ok.

i have a question regarding estrogen, i recently took a estrogen test (Eclia method) and it was 20.3, how does that correlate to an e2 sensitivity test? I have neverr gotten this "regular estrogen " test before so its new to me,, Thanks for Any information,,

 

[Eddie.]

Thank you for your reply. I appreciate the info. I had deleted my post because I thought maybe I had asked a stupid question. I guess you replied at about the same time.

Been having joint issues that I wasn’t having before was thinking about changing primo from a 5/3 to 5/2 ratio.

Yes do it and check again in 3-4 weeks. A 30 or even 35 ultrasensitive might suit you better, it's not all guys the same. I'm against at letting e2 climb very high but top of the range or slightly above is fine for most people.

i have a question regarding estrogen, i recently took a estrogen test (Eclia method) and it was 20.3, how does that correlate to an e2 sensitivity test? I have neverr gotten this "regular estrogen " test before so its new to me,, Thanks for Any information,,

Hey man, it's definitely on the low side for eclia, i'd like it at least double. I've gone as low as 25 but it was only for couple weeks, i don't remember feeling bad or smt but there's no reason to maintain it that low.

 

[Ateam2023]

Yes do it and check again in 3-4 weeks. A 30 or even 35 ultrasensitive might suit you better, it's not all guys the same. I'm against at letting e2 climb very high but top of the range or slightly above is fine for most people.




Hey man, it's definitely on the low side for eclia, i'd like it at least double. I've gone as low as 25 but it was only for couple weeks, i don't remember feeling bad or smt but there's no reason to maintain it that low.

yeah i figured it was on the low side, but thankfully i don't get any low e sides, i personally like my e2 to be in the 40's , thanks for reply, i wonder how i calculate this eclia method to the e2 sensitivity method,?

 

[Eddie.]

yeah i figured it was on the low side, but thankfully i don't get any low e sides, i personally like my e2 to be in the 40's , thanks for reply, i wonder how i calculate this eclia method to the e2 sensitivity method,?

There's no way to calculate it, in simple test i believe it cross detects some other estrogen types (like e1, e3 and total estrogen) as e2 leading to a little higher number, hence it's not the most accurate test. This may differ between genetics, the compounds being used etc. Take this with a grain of salt though, it's just my speculation.